Journal
OPTICS EXPRESS
Volume 23, Issue 7, Pages 9130-9136Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.23.009130
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Funding
- National Basic Research Program of China [2011CB910402, 2010CB732602]
- National Natural Science Foundation of China [61331001, 61361160414, 81127004]
- National High Technology Research and Development Program of China [2015AA020901]
- Guangdong Natural Science Foundation [S2013020012646, S2013040016419]
- National Key Technology RD Program [2012BAI13B00]
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We have developed an intravascular confocal photoacoustic (PA) endoscope with symmetrically aligned dual-element ultrasonic transducers. By combining focused laser excitation and focused acoustic collection, the intravascular confocal PA endoscope is capable of realizing resolution enhanced intravascular PA imaging with improved signal-to-noise ratio (SNR) to ameliorate the resolution reduction caused by laser scattering with increasing tissue depth. The detection sensitivity of the endoscope is improved by 5 dB compared with that of single transducer endoscope, and the transverse resolution of the system can up to 13 mu m. Intravascular PA tomography of a normal vessel and an atherosclerotic vessel have been performed to demonstrate the imaging ability of the system. This intravascular confocal PA endoscope with an outer diameter of 1.2 mm supports potential for clinical applications in intravascular plaque imaging and subsequent diagnosis. (C) 2015 Optical Society of America
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