Journal
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
Volume 38A, Issue 12, Pages 2508-2512Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jhsa.2013.08.120
Keywords
CLOVES; overgrowth syndromes; vascular anomalies
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A cohort of patients with overgrowth syndromes has been identified with congenital lipomatons overgrowth, dysregulated fat deposits, and mixed vascular malformations. The acronym CLOVES was given on a heuristic basis to stand for congenital lipomatous overgrowth (CLO), vascular malformation (V), epidermal nevi (E), and scoliosis and spinal deformities (S). These patients have upper limb anomalies with variable phenotypes. Although hand anomalies alone cannot make the diagnosis, the foot, truncal, cutaneous and spinal anomalies are particularly diagnostic. CLOVES syndrome has emerged as a distinct clinical entity diagnosed by clinical and radiographic examinations. The overgrowth pattern is now easily distinguished from other overgrowth syndromes. (Copyright (C) 2013 by the American Society for Surgery of the Hand. All rights reserved.)
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