Journal
JOURNAL OF GYNECOLOGIC ONCOLOGY
Volume 24, Issue 4, Pages 336-341Publisher
KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
DOI: 10.3802/jgo.2013.24.4.336
Keywords
Adiponectin; Endometrial carcinoma; Insulin resistance; Leptin
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Funding
- Fundamental Research Funds for the Central Universities
- Director Foundation from Zhejiang Key Laboratory, China
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Objective: To investigate the relationship between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women. Methods: We conducted a case-control study of a total of 516 Chinese women to detect the relationships between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women. The study subject constituted 206 cases of endometrial cancer and 310 normal controls. Results: Patients with endometrial carcinoma had higher serum leptin concentrations than controls (28.8 +/- 2.2 ug/L vs. 19.8 +/- 1.4 ug/L; p<0.001). The adipbnectin levels in patients were lower than in controls with borderline statistical significance (2,330.7 +/- 180.5 ug/L vs. 2,583.9 +/- 147.2 ug/L; p=0.078). Logistic regression analysis confirmed the associations between leptin or adiponectin, and endometrial carcinoma after adjustment for age, body mass index, fasting insulin, serum glucose, cholesterol, triglycerides, and high-density lipoprotein cholesterol (odds ratio for the top tertile vs. the bottom tertile: leptin 2.05; 95% confidence interval [Cl], 1.28 to 3.29; p<0.001; adiponectin 0.52; 95% Cl, 0.32 to 0.83; p<0.001). Conclusion: Increased leptin or decreased adiponectin levels are associated with endometrial carcinoma.
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