Review
Oncology
Xiaoyan Wang, Lifeng Yang, Yan Wang
Summary: F-18-FDG PET/CT has good diagnostic accuracy and value in detecting the recurrence of epithelial ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Oncology
Casey W. Williamson, Dmitriy Zamarin, Jyoti Mayadev
Summary: In cervical cancer, PET imaging with maximum standardized uptake value (SUVmax) has prognostic significance. Low pretreatment SUVmax is associated with a better prognosis and correlated with decreased inflammatory signaling and myeloid-derived cell infiltration, potentially indicating susceptibility to targeted therapies.
CLINICAL CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Alisa N. Blumenthaler, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Chad D. Strange, Mara B. Antonoff
Summary: The study investigates the association between maximum standardized uptake value (SUVmax) and recurrence risk after resection of early-stage non-small cell lung cancer. The results suggest that SUVmax is independently associated with recurrence risk and may be a valuable tool for stratifying patients with early-stage lung cancer for adjuvant therapy and surveillance.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Joseph DeMari, Monica Hagan Vetter, Shruthi Chandra, John L. Hays, Ritu Salani
Summary: The study aimed to investigate practice patterns for surveillance of primary ovarian cancer after complete response to therapy, and to identify the percentage of clinicians who follow the surveillance guidelines endorsed by the Society of Gynecologic Oncology. Results showed that 78% of patients complied with the guidelines, but patients with early-stage cancer and non-serous histologies were more likely to be non-compliant.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Medicine, Research & Experimental
Ruyue Li, Shaohan Ma, Yizheng Zu, Fang Wang, Tingting Gao, Yu'e Yang, Hua Guo, Chunfang Ha
Summary: This study assessed the predictive and diagnostic value of the ROMA index for EOC recurrence. The results showed that the ROMA index was strongly associated with clinical characteristics and had a significant association with recurrence-free survival above the cutoff value. The ROMA index had a higher sensitivity than CA125 and HE4 for recurrence diagnosis.
BIOMARKERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiantao Pu, Joseph K. Leader, Dongning Zhang, Cameron A. Beeche, Jacob Sechrist, Arjun Pennathur, Liza C. Villaruz, David Wilson
Summary: The study investigated the potential relationship between macrovasculature features and PET SUV of lung tumors. Results showed a positive correlation between PET SUV and vessel volume and vessel number, while adjusting for tumor size revealed significant correlations with vessel tortuosity and vessel number, but only marginal correlation with vessel volume. The multiple regression model exhibited a moderate performance in predicting PET SUV based on relevant image features.
Article
Reproductive Biology
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Tariq Masoodi, Padmanaban Annaiyappanaidu, Ismail A. Al-Badawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: Our study shows that the expression of CDK9 in Middle Eastern ethnicity ovarian cancer correlates with markers of advanced disease and serves as a prognostic marker. CDK9 overexpression also identifies a subset of patients with the highest likelihood of recurrence.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kuo-Wei Ho, Ku-Hao Fang, Chang-Hsien Lu, Cheng-Ming Hsu, Chia-Hsuan Lai, Chun-Ta Liao, Chung-Jan Kang, Yuan-Hsiung Tsai, Ming-Shao Tsai, Ethan I. Huang, Geng-He Chang, Chien-An Ko, Ming-Hsien Tsai, Yao-Te Tsai
Summary: We investigated the prognostic value of preoperative neck lymph node-to-primary tumor maximum standardized uptake value ratios (NTRs) in oral cavity squamous cell carcinoma (OSCC). We retrospectively reviewed the medical records of 141 OSCC patients who underwent fluorodeoxyglucose-positron emission tomography prior to radical surgery. The results showed that patients with a higher NTR (≥0.273) had significantly worse disease-free survival (DFS) and overall survival (OS) compared to those with a lower NTR.
Article
Oncology
Szymon Piatek, Iwona Szymusik, Piotr Sobiczewski, Wojciech Michalski, Magdalena Kowalska, Mariusz Oltarzewski, Mariusz Bidzinski
Summary: This study aimed to evaluate the recurrence and birth rates among patients with non-epithelial ovarian cancer. A total of 146 patients who underwent fertility-sparing surgery for germ cell (GCT) and sex cord-stromal tumors (SCST) were included. The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. After a 24-month follow-up, the recurrence rate was higher than the rate of childbearing, but after 2 years, the childbearing rates exceeded the rate of recurrence.
Article
Oncology
John M. Floberg, Jin Zhang, Naoshad Muhammad, Todd A. DeWees, Matthew Inkman, Kevin Chen, Alexander J. Lin, Ramachandran Rashmi, Kay Jayachandran, Brian T. Edelson, Barry A. Siegel, Farrokh Dehdashti, Perry W. Grigsby, Stephanie Markovina, Julie K. Schwarz
Summary: This study found that SUVmax <11.4 was the most predictive for freedom from progression in cervical cancer patients. High SUVmax is associated with activation of inflammatory pathways and infiltration of myeloid-derived immune cells, particularly monocytes and macrophages. Macrophages contribute to changes in cervical cancer glucose metabolism.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Li Ning, Jinghe Lang, Bo Long, Lingying Wu
Summary: CircN4BP2L2 may serve as a promising diagnostic biomarker for both type I and type II EOC. It was associated with advanced tumor stage in type I EOC and lymph node metastasis in type II EOC. CircN4BP2L2 could significantly separate type I or type II from benign or normal cohort.
Article
Oncology
Ji-Won Ryu, Ha-Yeon Shin, Hyo-Sun Kim, Gwan Hee Han, Jeong Won Kim, Hae-Nam Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: Hormonal factors, particularly steroid hormones, are believed to play a significant role in ovarian cancer development. The expression of glucocorticoid receptor (GR) has been associated with poor prognosis in epithelial ovarian cancer. This study investigates the clinical significance of beta-arrestin expression in ovarian cancer and the potential synergistic effect with GR as prognostic factors. The findings demonstrate a moderate correlation between beta-arrestin 1 and GR expression, suggesting a possible role in prognostication.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Reproductive Biology
Yi Hu, Kun Fu, Huining Liu, Qiongqiong He, Xiaoqin Qiu, Wenqing Yang, Yu Zhang
Summary: This study aimed to investigate whether ovarian seromucinous carcinoma truly represented a distinct category of ovarian tumors or an analogue of ovarian endometrioid carcinoma. Through the analysis of clinicopathological features and prognosis of 12 patients, it was found that ovarian seromucinous carcinoma and ovarian endometrioid carcinoma had significant differences in clinical characteristics and prognosis, indicating that direct classification of ovarian seromucinous carcinoma as ovarian endometrioid carcinoma is not appropriate.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Ragab, Jianrong Wu, Xue Ding, Aurela Clark, Blaine Mischen, Aman Chauhan, M. Elizabeth Oates, Lowell Anthony, Riham El Khouli
Summary: The study found that SUL is a more reproducible and less variable quantitative measure in DOTA PET/CT scans compared to SUVbw. Among organs with physiological uptake, liver SUL is identified as the optimal internal reference due to its larger size and uniform SUL values resulting in lower variability and better reproducibility.
ACADEMIC RADIOLOGY
(2022)
Review
Cell Biology
Revathy Nadhan, Ciro Isidoro, Yong Sang Song, Danny N. Dhanasekaran
Summary: This review summarizes the structure and function of long non-coding RNAs (lncRNAs) in cellular signaling networks, as well as their mechanisms of action. It provides insights into the pathogenesis of cardiovascular diseases, neurological disorders, cancers, and diabetes mellitus, highlighting the role of lncRNAs. The review suggests that lncRNAs could be potential therapeutic targets.
Review
Oncology
Panagiotis A. Konstantinopoulos, Antonio Gonzalez-Martin, Felipe Melo Cruz, Michael Friedlander, Rosalind Glasspool, Domenica Lorusso, Christian Marth, Bradley J. Monk, Jae-Weon Kim, Patsy Hinson, Olga Ajipa, Vincent Pretre, Yu Han, Ursula A. Matulonis
Summary: This article describes a study investigating the combination of the specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib and the poly (adenosine diphosphateribose) polymerase (PARP) inhibitor olaparib in platinum-resistant or -refractory high-grade serous ovarian cancer (HGSOC) patients without germline BRCA mutation. The study aims to improve the prognosis of patients with this condition.
Article
Biochemistry & Molecular Biology
Sera Oh, Hyewon Youn, Jin Chul Paeng, Young-Hwa Kim, Chul-Hee Lee, Hongyoon Choi, Keon Wook Kang, June-Key Chung, Gi Jeong Cheon
Summary: This study evaluated the changes in tumor imaging biomarkers following ICI treatment, finding that a combination of F-18-FDG and F-18-FLT uptake rates could serve as potentially effective biomarkers for monitoring ICI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Reeree Lee, Han-Byoel Lee, Jin Chul Paeng, Hongyoon Choi, Wonseok Whi, Wonshik Han, Ju Won Seok, Keon Wook Kang, Gi Jeong Cheon
Summary: The expression of AR in TNBC is associated with low glucose metabolism, and the expression of AR is negatively correlated with SUVmax of tumors.
Article
Biochemistry & Molecular Biology
Hye Jung Jang, Myung Geun Song, Cho Rong Park, Hyewon Youn, Yun-Sang Lee, Gi Jeong Cheon, Keon Wook Kang
Summary: Glioblastoma is a common and fatal primary glioma, but complete removal of brain tumor tissues is challenging for neurosurgeons. Fluorescence-guided surgery (FGS) and indocyanine green (ICG) are used to enhance visualization of tumor edges. The binding properties of ICG to human serum albumin (HSA) and the extracellular glycoprotein SPARC were studied. In vitro and in vivo studies showed that the uptake of ICG-HSA complex was higher in SPARC-expressing glioblastoma cells and tumors compared to free ICG. This suggests that ICG-HSA complex could be an efficient imaging agent for SPARC-expressing tumors, especially glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
David Tan, Noriko Fujiwara, Keiichi Fujiwara, Philip Beale, Jae-Weon Kim, Joseph Ng, Se Ik Kim, Alison Evans, Byoung-Gie Kim
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Multidisciplinary Sciences
Chang Hyun Nam, Jeonghwan Youk, Jeong Yeon Kim, Joonoh Lim, Jung Woo Park, Soo A. Oh, Hyun Jung Lee, Ji Won Park, Hyein Won, Yunah Lee, Seung-Yong Jeong, Dong-Sung Lee, Ji Won Oh, Jinju Han, Junehawk Lee, Hyun Woo Kwon, Min Jung Kim, Young Seok Ju
Summary: This study uncovers the mutational landscape induced by L1 retrotransposition in normal cells and reveals a positive relationship between somatic L1 retrotransposition and age.
Article
Oncology
Soseul Sung, Youjin Hong, Byoung-Gie Kim, Ji-Yeob Choi, Jae Weon Kim, Sang-Yoon Park, Jae-Hoon Kim, Yong-man Kim, Jong-Min Lee, Tae Jin Kim, Sue K. K. Park
Summary: This study aimed to verify the association between ovarian cancer (OC) and reproductive- and lifestyle-related risk factors stratified by the subtype of OC. The results showed that smoking was positively associated with high-grade serous (HGS) OC, alcohol consumption was positively associated with mucinous type (MUC), and obesity was associated with clear cell type (CLC). Further, spontaneous abortion was negatively associated with CLC, while tubal ligation, hysterectomy, and oophorectomy were associated with decreased risk of HGS. Early menarche was strongly associated with increased risk of CLC. Additionally, childbirth, oral contraceptives, and hormone replacement therapy were negatively associated with OC.
Review
Biochemistry & Molecular Biology
Revathy Nadhan, Srishti Kashyap, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro, Danny N. Dhanasekaran
Summary: Peritoneal cancers pose significant challenges in clinical practice and have a poor prognosis. Understanding cancer cell metabolism and cancer-promoting metabolites in peritoneal cancers can provide new insights into tumor progression mechanisms, identify therapeutic targets and biomarkers, and improve treatment outcomes for patients.
Article
Biochemistry & Molecular Biology
Ho Rim Oh, Min Kyung Ko, Daehee Son, Young Wook Ki, Shin-Il Kim, Seok-Yong Lee, Keon Wook Kang, Gi Jeong Cheon, Do Won Hwang, Hyewon Youn
Summary: Activated hepatic stellate cells (HSCs) play a detrimental role in liver fibrosis progression. Natural killer (NK) cells have therapeutic effects in a CCl4-induced liver cirrhosis mouse model by reducing collagen deposition, HSC marker activation, and macrophage infiltration. The repetitive administration of NK cells alleviates liver fibrosis through anti-fibrotic and anti-inflammatory mechanisms.
Article
Cell Biology
Rebecca Yun, Eunji Hong, Junil Kim, Bora Park, Staci Jakyong Kim, Bona Lee, Yong Sang Song, Seong-Jin Kim, Sujin Park, Jin Muk Kang
Summary: This study reveals the crucial role of N-linked glycosylation in the functional post-translational modification of KIAA1324, which is important for suppressing cancer cell proliferation and migration in gastric cancer. Inhibition of glycosylation and fucosylation also inhibits KIAA1324-induced cell growth inhibition and apoptosis. Additionally, the study shows that N-linked glycosylation decreases protein stability through rapid proteasomal degradation. Overall, this research highlights the significance of post-translational modifications in KIAA1324 for gastric cancer progression.
CELL DEATH & DISEASE
(2023)
Article
Nanoscience & Nanotechnology
Jie Wang, Keon Wook Kang, Seongtae Bae
Summary: The contribution of spatial homogeneity of magnetic nanofluids to r(2)-relaxivity and T-2-weighted MR contrast efficiency is crucial, but controversial. This study provides scientific clues to solve the controversies by experimentally and theoretically studying the effects of spatial homogeneity on r(2)-relaxivity. The magnetic energy competition model and water accessibility model are critical for interpreting the effects of spatial homogeneity on r(2)-relaxivity for T-2-weighted MR imaging.
ACS APPLIED NANO MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo Sang Lee, Hyun Woo Kwon, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Yong Sang Hong, Tae Won Kim, Minyoung Oh, Sangwon Han, Jae Hwan Oh, Sohyun Park, Tae-Sung Kim, Seok-ki Kim, Hyun Joo Kim, Jae Young Kwak, Ho-Suk Oh, Sungeun Kim, Jung-Myun Kwak, Ji Sung Lee, Jae Seung Kim
Summary: This study developed and validated a prognostic model based on FDG metabolic parameters for predicting recurrence after surgery for colorectal cancer liver metastasis. The model showed good discrimination and calibration in external validation, and can be used for accurate risk stratification in patients with synchronous colorectal cancer liver metastasis.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Seok-Yong Lee, Ho Rim Oh, Young-Hwa Kim, Sung-Hwan Bae, Yongseok Lee, Yun-Sang Lee, Byung Chul Lee, Gi Jeong Cheon, Keon Wook Kang, Hyewon Youn
Summary: This study aimed to evaluate the usefulness of TSPO-CLI in iBAT imaging in UCP1 ThermoMouse. The results showed that the TSPO-targeting probe was superior to [F-18]FDG in acquiring iBAT images, and TSPO-PET/CLI better reflected UCP1 expression. Therefore, TSPO-CLI could be used as an alternative technique for iBAT imaging.
Review
Oncology
Jeong-Yeol Park, Jung-Yun Lee, Yoo-Young Lee, Seung-Hyuk Shim, Dong Hoon Suh, Jae-Weon Kim
Summary: This review summarizes the major clinical research advances in gynecologic oncology, including treatment modalities and drug research for cervical cancer, ovarian cancer, and uterine corpus cancer. The study findings demonstrate the effectiveness and survival outcomes of new treatment strategies and drugs for these cancers.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)