Journal
JOURNAL OF GLAUCOMA
Volume 21, Issue 6, Pages 358-366Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IJG.0b013e3182120700
Keywords
optic disc hemorrhage; glaucoma progression; optical coherence tomography
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Funding
- National Research Foundation of Korea (NRF) grant
- Korea government (MEST) [2009-0091931]
- National Research Foundation of Korea [2009-0091931] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Purpose: To evaluate the progression of glaucoma after first detected disc hemorrhage (DH) by time-domain optical coherence tomography (OCT). Methods: Forty-four eyes with a unilateral DH were allocated to the DH group and 44 fellow eyes to the non-DH group. OCT signal decrease indicating retinal nerve fiber layer thinning was defined as a decrease beyond the upper 95% limit of test-retest variability defined at the 95% confidence level of 44 control patients. The DH and non-DH groups were compared in terms of OCT-derived glaucoma progressions after the first detected DH. In addition, clock-hour locations of the OCT-derived progression were compared with those of DHs. Results: After a median 38.8 +/- 10.8 months of follow-up, 72.7% (32 of 44) of eyes in the DH group showed OCT-determined progression on a clock-hour basis, compared with 27.3% (12 of 44) of the fellow eyes in the non-DH group (P < 0.0001, Fisher exact test). Eyes in the DH group showed more rapid and greater falls in clock-hour-based progression than fellow eyes in the non-DH group (P < 0.0001, log-rank test). Twenty-nine eyes (90.6%) showed progression within 1 clock hour of the location of DH. However, no significant intergroup differences were observed in terms of OCT-determined progression on quadrant or average basis (P > 0.05, respectively, Fisher exact test). Conclusions: Rapid, spatially compatible, localized thinning of the retinal nerve fiber layer after the first detected DH was shown by Stratus OCT.
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