Article
Neurosciences
Youichi Shinozaki, Kozo Saito, Kenji Kashiwagi, Schuichi Koizumi
Summary: ATP, the energy source in cells, can be released to the extracellular space and serve as a signaling molecule. In the eye, ATP release in response to physiological stimuli regulates intraocular pressure, and dysregulated ATP signaling may contribute to elevated intraocular pressure and glaucoma pathogenesis.
Article
Ophthalmology
Henrietta Ho, Arij Daas, Jason Ho, Pouya Alaghband, Elizabeth Angela Galvis, Alba de Antonio Ramirez, Piergiacomo Grassi, Rongxuan Lim, Kin Sheng Lim
Summary: The study reviewed changes in intraocular pressure (IOP) following topical hypotensive medications washout in patients with primary open angle glaucoma (POAG), ocular hypertension (OHT) and uveitic glaucoma (UG)/OHT. Results showed a significant increase in IOP after washout in all groups, with UG patients showing a lower increase. Active inflammation and steroid treatment contribute to elevated IOP in uveitis, recommending washout in UG patients with controlled IOP in the absence of uveitis recurrence.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
David Kuerten, Matthias Fuest, Peter Walter, Babac Mazinani, Niklas Plange
Summary: The study found a relationship between retinal blood flow alterations and contrast sensitivity loss in patients with normal tension glaucoma, indicating a disease-related link between retinal blood flow and visual function. However, this association was not observed in healthy volunteers.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Xinyue Zhang, Xiaoyu Zhou, Yang Zhao, Xiang Yang, Dengming Zhou, Baihua Chen, Xuanchu Duan
Summary: Tafluprost may have a positive effect on ocular blood flow, independent of its ability to lower intraocular pressure, and reducing intracellular free Ca2+ concentration may be a possible mechanism of this effect. Further well-designed studies are needed to reveal the truth.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Chemistry, Analytical
Xiaobin Xu, Zixuan Liu, Liqiang Wang, Yifei Huang, He Yang
Summary: In this paper, a thin-film integrated optical IOP sensor based on the interferometry principle was designed to read out the IOP value by interference patterns and monitor the value changes real-time. The results showed that our sensor exhibited a sensitivity of 0.19 mu m/mmHg and an average accuracy of 0.84 mmHg over the pressure range of 0-45 mmHg, with the advantage of easier fabrication process and low-cost compared to other optical systems. Our sensor device implies great potential in the application of human physiological index measurement and other chip-integrated medical sensing instruments.
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Thomas Graf, Gitanas Kancerevycius, Linas Jonusauskas, Patric Eberle
Summary: This article presents a systematic approach to develop a microchannel stent meshwork for the treatment of glaucoma. The stent allows for regulated drainage of aqueous humor and control of intraocular pressure.
Article
Ophthalmology
Elena Bastia, Carol B. Toris, Stefania Brambilla, Corinna Galli, Nicoletta Almirante, Michael V. W. Bergamini, Emanuela Masini, Silvia Sgambellone, Andrea M. Unser, Feryan Ahmed, Karen Y. Torrejon, Tomas Navratil, Francesco Impagnatiello
Summary: NCX 667 demonstrates robust and dose-dependent IOP-lowering effects in multiple animal models, likely resulting from NO-mediated increase of the conventional outflow pathway. Other mechanisms such as changes in AH production and episcleral vein pressure may also contribute to the observed effects.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Manoj Mathur, P. Ratnam, S. J. Saikumar, Manuel John, Siddharth Ravishankar, M. B. Dinesh, Priya Chandil, Kishore Pahuja, Vidya Cherlikar, Sunny Wadhwani, Pankaj Bendale, Ajit Hazari, Rajesh Mishra, Susheel Deshmukh, Rahul Achlerkar, Devang Shah, Chanda Hingorani, Kaivan Shah, Pratik Topiwala, Sheetal Jani, Viral Rana, Nilay Majumdar, Debasis Chakrabarti, Rituparna Dey, Debabrata Halder, Sumit Choudhury, Ajeet Kumar, Sasmita Das, Ashok Nanda, Vidya Kumar, Rama Dubey, Gulam Kamdar, Alka Pandey, Sheetal Kishanpuria, Rajat Srivastava, Parul Singh, Sunil Verma, Neha Sharma, Rajeev Gupta
Summary: This study demonstrates that monotherapy with netarsudil 0.02% w/v solution is safe and effective as a first-line treatment for primary open-angle glaucoma and ocular hypertension. Patients only experienced a small number of tolerable adverse effects.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Chemistry, Medicinal
Najam A. Sharif
Summary: Chronically raised intraocular pressure (IOP) in glaucoma patients leads to serious vision loss due to progressive degeneration of retinal and brain neurons involved in visual perception. Ocular hypertension (OHT) is a major risk factor, resulting from the accumulation of excess aqueous humor (AQH) fluid in the eye. Despite advances in pharmaceuticals and treatments, early diagnosis of OHT and glaucoma still requires further attention.
Article
Ophthalmology
Peter Szurman, Kevin Gillmann, Anna -Maria Seuthe, H. Burkhard Dick, Esther M. Hoffmann, Andre Mermoud, Marc J. Mackert, Robert N. Weinreb, Harsha L. Rao, Kaweh Mansouri
Summary: The EYEMATE-SC sensor was found to be safe and well tolerated throughout a 12-month period in patients undergoing nonpenetrating glaucoma surgery. It provided accurate and continuous monitoring of intraocular pressure.
Article
Multidisciplinary Sciences
Ryan H. Somogye, Cynthia J. Roberts, Eberhard Spoerl, Karin R. Pillunat, Lutz E. Pillunat, Robert H. Small
Summary: The purpose of this study was to develop a non-invasive method for estimating pulsatile ocular blood volume (POBV) using measurements taken during an ophthalmic exam. The study used unpublished data from a previous invasive study along with measurements of intraocular pressure (IOP) and ocular pulse amplitude (OPA). The study found that POBV had a positive relationship with OPA and a negative relationship with diastolic IOP, suggesting that higher IOP combined with lower OPA resulted in lower POBV. The ratio of OPA to diastolic IOP may also be a useful clinical tool for evaluating changes in ocular blood supply in diseases with a vascular component.
Article
Chemistry, Medicinal
Cristina Minnelli, Francesco Piva, Monia Cecati, Tatiana Armeni, Giovanna Mobbili, Roberta Galeazzi, Alberto Melecchi, Martina Cristaldi, Roberta Corsaro, Dario Rusciano
Summary: MID is a synthetic drug that decreases the availability of L-carnitine, which is important for mitochondria energy generation, thus modulating energy metabolism pathways. It has shown protective effects on blood vessels in models of endothelial dysfunction induced by high glucose or hypertension.
Article
Medicine, General & Internal
Justin T. Bradshaw, Telyn Peterson, Lawsen M. Parker, Zeke Richards, Chad J. Skidmore, Kevin Brighton, Maxton W. Muir, Alexandra Moody, Andrew Collyer, Isain Zapata, Amanda E. Brooks, Marcos Reyes
Summary: Glaucoma is a leading cause of irreversible blindness worldwide. This study suggests that allowing medical students to perform community-based glaucoma screening events in medically underserved areas can decrease the cost burden associated with late diagnosis and raise awareness about glaucoma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Jihee Kim, Stuart K. Gardiner, Andrea Ramazzotti, Udayakumar Karuppanan, Luigi Bruno, Christopher A. Girkin, J. Crawford Downs, Massimo A. Fazio
Summary: The study showed that using virtual extensometers for video imaging allowed for repeatable measurements of tissue specific deformations, with the highest strain observed in the choroid after IOP elevation.
EXPERIMENTAL EYE RESEARCH
(2021)
Letter
Ophthalmology
Gabriel Katz, Rita Ehrlich
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Rita Ehrlich, Yi Wei Goh, Nadeem Ahmad, Philip Polkinghorne
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2012)
Article
Ophthalmology
Rita Ehrlich, Philip Polkinghorne
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2011)
Article
Ophthalmology
Rita Ehrlich, Dov Weinberger, Ethan Priel, Ruth Axer-Siegel
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2008)
Article
Ophthalmology
Rita Ehrlich, Rachael L. Niederer, Nadeem Ahmad, Philip Polkinghorne
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2013)
Article
Ophthalmology
Ingrida Januleviciene, Rita Ehrlich, Brent Siesky, Irena Nedzelskiene, Alon Harris
JOURNAL OF OPHTHALMOLOGY
(2011)
Article
Ophthalmology
R Ehrlich, D Weinberger, R Axer-Siegel
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2005)
Article
Ophthalmology
Yonina Ron, Rita Ehrlich, Ruth Axer-Siegel, Irit Rosenblatt, Dov Weinberger