Article
Multidisciplinary Sciences
Jooyoung Yoon, Ko Eun Kim, Anna Lee, Woo Keun Song, Michael S. Kook
Summary: This study investigated the relationship between foveal avascular zone (FAZ)-related parameters and visual field (VF) progression in early-stage open-angle glaucoma (OAG) eyes with central visual field (CVF) defects using optical coherence tomography angiography (OCT-A). The results showed that the rates of reduction in vessel density and macular ganglion cell-inner plexiform layer thickness were faster in progressors than in non-progressors. Faster rates of VF reduction were associated with faster rates of vessel density loss and macular ganglion cell-inner plexiform layer thickness reduction.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Assaf Gershoni, Edward Barayev, Igor Vainer, Raviv Allon, Roy Yavnieli, Yinon Shapira, Michael Mimouni, Noa Geffen, Arie Yehuda Nemet, Ori Segal
Summary: This study investigated the influence of signal strength on measurements of macular thickness, macular volume, and RNFL thickness in spectral-domain OCT. The results showed that higher signal strength was associated with lower measurements. The mean differences between high and low-quality measurements were small, indicating that SD-OCT is a reliable imaging tool.
Article
Ophthalmology
Yumi Lee, Kyung-Ah Park, Sei Yeul Oh
Summary: The study found that in patients with NAION, the peripapillary retinal nerve fiber layer and macular outer nuclear layer were thicker within 2 months of onset compared to controls. However, within 2-5 months, there was thinning in the peripapillary retinal nerve fiber layer, macular retinal nerve fiber layer, and ganglion cell layer and inner plexiform layer, which was associated with final visual field outcomes.
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthias M. Mauschitz, Valerie Lohner, Alexandra Koch, Tony Stocker, Martin Reuter, Frank G. Holz, Robert P. Finger, Monique M. B. Breteler
Summary: Retinal assessments may serve as biomarkers for neurodegenerative diseases and be used as clinical monitoring tools.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Henrik Ehrhardt, Jeffrey Lambe, Hussein Moussa, Eleni S. Vasileiou, Grigorios Kalaitzidis, Olwen C. Murphy, Angeliki G. Filippatou, Nicole Pellegrini, Morgan Douglas, Simidele Davis, Natalia Nagy, Agustina Quiroga, Chen Hu, Alexandra Zambriczki Lee, Anna Duval, Kathryn C. Fitzgerald, Jerry L. Prince, Peter A. Calabresi, Elias S. Sotirchos, Robert Bermel, Shiv Saidha
Summary: In this post hoc analysis of the SPRINT-MS trial, it was found that ibudilast therapy can slow down GCIPL atrophy in PMS, particularly in the PPMS cohort. The rates of GCIPL, INL, and ONL atrophy were correlated with whole brain atrophy rates.
Article
Multidisciplinary Sciences
Md. Hasnat Ali, Brian Wainwright, Alexander Petersen, Ganesh B. Jonnadula, Meghana Desai, Harsha L. Rao, M. B. Srinivas, S. Rao Jammalamadaka, Sirisha Senthil, Saumyadipta Pyne
Summary: Progressive optic neuropathies such as glaucoma are major causes of blindness globally, but clinicians often face subjective and analytical challenges in early diagnosis and clinical management. Structural heterogeneity in the eyes may play a key role in the progression of optic neuropathies, presenting challenges to clinical decision-making.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jeffrey Lambe, Kathryn C. Fitzgerald, Olwen C. Murphy, Angeliki G. Filippatou, Elias S. Sotirchos, Grigorios Kalaitzidis, Elena Vasileiou, Nicole Pellegrini, Esther Ogbuokiri, Brandon Toliver, Nicholas J. Luciano, Simidele Davis, Nicholas Fioravante, Ohemaa Kwakyi, Hunter Risher, Ciprian M. Crainiceanu, Jerry L. Prince, Scott D. Newsome, Ellen M. Mowry, Shiv Saidha, Peter A. Calabresi
Summary: This study found that lower baseline Ganglion Cell + Inner Plexiform Layer (GCIPL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) is independently associated with long-term disability worsening in multiple sclerosis (MS). Therefore, a single-time SD-OCT examination may help guide therapeutic decision-making among individual PwMS.
Article
Ophthalmology
Maria Satue, Luisa Castro, Elisa Vilades, Beatriz Cordon, Jose M. Errea, Ana Pueyo, Eva Pilar Chueca, Elena Garcia-Martin
Summary: The ability of swept-source optical coherence tomography with angiography analysis (SS-OCTA) to detect neuro-retinal and vasculature changes in patients with Parkinson's disease (PD) and essential tremor (ET) was evaluated. The study showed that neuro-retinal thinning was present in both diseases, with greater thinning observed in PD. SS-OCTA may be useful in diagnosing PD, but not ET.
Article
Multidisciplinary Sciences
Rebecca A. Cox, Scott A. Read, Shelley Hopkins, David Alonso-Caneiro, Joanne M. Wood
Summary: Significant differences were found in macular retinal thickness between Australian Aboriginal and/or Torres Strait Islander children and non-Indigenous children, which has implications for interpreting optical coherence tomography data and evaluating the risk of macula disease in this population.
Article
Multidisciplinary Sciences
David Paul, Alejandra Rodrigue, Nicholas Contento, Sam Haber, Ricky Hoang, Redi Rahmani, Adnan C. Hirad, Ismat C. Shafiq, Zoe C. Williams, G. Edward C. Vates
Summary: This study found that moderately increased serum prolactin levels are associated with increased RNFL thickness. This suggests a neuroprotective effect of moderately increased prolactin levels in preserving retinal function during optic chiasm compression.
Article
Multidisciplinary Sciences
Huiyuan Hou, Nevin W. EI-Nimri, Mary K. Durbin, Juan D. Arias, Sasan Moghimi, Robert N. Weinreb
Summary: This study compared the agreement of Wide scan measurements between two different optical coherence tomography devices and found good agreement between the two devices. Wide scan may have a potential role in the diagnosis and management of glaucoma.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Jihei Sara Lee, Youngmin Park, Sungeun Park, Mijeong Kim, Chan Yun Kim, Wungrak Choi, Sang Yeop Lee, Hyoung Won Bae
Summary: This study aimed to examine the clinical characteristics associated with structural progression in open-angle glaucoma (OAG) in the presence of macular vessel density (MvD) in different locations. The findings showed that thinning of the retinal nerve fiber layer (RNFL) was more pronounced in eyes with inferior MvD compared to those with temporal MvD when there was greater long-term intraocular pressure (IOP) fluctuation. This suggests that IOP fluctuation may play a role in the structural progression of OAG eyes with inferior MvD.
Article
Health Care Sciences & Services
Sueheda Kaya, Mehmet Kaan Kaya
Summary: The purpose of this study was to compare the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) with healthy controls. The OCT findings showed no differences in macular thickness and volume between the two groups, but the retinal nerve fiber layer (RNFL) measurements were thicker in the MUD group. Further studies are needed to support the use of OCT as an effective method for demonstrating potential neurodegeneration in MUD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Adam Ruff, Alangoya Tezel, Tongalp H. Tezel
Summary: Cystoid macular edema (CME) is a significant cause of central visual deterioration in patients with retinitis pigmentosa. Age, retinal nerve fiber layer area, and outer retinal area are the main determinants of CME size, while length of intact ellipsoid zone, inheritance pattern, and retinal nerve fiber layer area are the main determinants of visual acuity.