Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Silvia Alonso-Lana, Carrie E. Bearden, Alessandro Bertolino, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Erick J. Canales-Rodriguez, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena de la Serna, Caterina del Mar Bonnin, Caroline Demro, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Mar Fatjo-Vilas, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Jose M. Goikolea, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Ceren Hidiroglu Ongun, Manon H. J. Hillegers, Josselin Houenou, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Leila Nabulsi, Jason Newport, Cheryl A. Olman, Jim van Os, Bronwyn J. Overs, Aysegul Ozerdem, Giulio Pergola, Marco M. Picchioni, Camille Piguet, Edith Pomarol-Clotet, Joaquim Radua, Ian S. Ramsay, Anja Richter, Gloria Roberts, Raymond Salvador, Aybala Saricicek Aydogan, Salvador Sarro, Peter R. Schofield, Esma M. Simsek, Fatma Simsek, Jair C. Soares, Scott R. Sponheim, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Eduard Vieta, Henrik Walter, Daniel R. Weinberger, Heather C. Whalley, Mon-Ju Wu, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Sophia I. Thomopoulos, Theo G. M. van Erp, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
Summary: First-degree relatives of patients diagnosed with schizophrenia show widespread thinner cortex, while relatives of patients diagnosed with bipolar disorder show widespread larger cortical surface area. Both groups have lower IQ scores compared to controls, with schizophrenia relatives showing more pronounced brain abnormalities and bipolar disorder relatives showing weaker effects after adjusting for IQ or educational attainment.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Petra E. Rupert, Michael Pogue-Geile
Summary: This meta-analysis compared the functional brain similarities and differences between individuals at familial risk for schizophrenia (FRSZ) or bipolar disorder (FRBD). The results showed that FRSZ individuals had lower activation in the left precuneus and left middle frontal gyrus compared to controls. FRBD individuals had lower activation in the left superior parietal gyrus and right angular gyrus, and higher activation in the left superior frontal gyrus compared to controls. No significant differences were found between FRSZ and FRBD.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Rositsa Paunova, Cristina Ramponi, Sevdalina Kandilarova, Anna Todeva-Radneva, Adeliya Latypova, Drozdstoy Stoyanov, Ferath Kherif
Summary: In this study, multivariate methods were used to identify key brain regions involved in shaping connectivity patterns of networks associated with major psychiatric disorders. The results suggest that the multivariate structural covariance method can be used to identify specific regions with higher predictive value for specific psychiatric diagnoses.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Parya Valizadeh, Giulia Cattarinussi, Fabio Sambataro, Paolo Brambilla, Giuseppe Delvecchio
Summary: This review examines the impact of medication on neuroimaging findings in pediatric bipolar disorder (PBD). The results show that medication primarily affects the prefrontal cortex and amygdala, and has the potential to normalize brain structure and function in key mood-regulating regions.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Licia P. Luna, Joaquim Radua, Lydia Fortea, Gisela Sugranyes, Adriana Fortea, Paolo Fusar-Poli, Lee Smith, Joseph Firth, Jae Il Shin, Andre R. Brunoni, Muhammad I. Husain, Muhammad O. Husian, Haris I. Sair, Walber O. Mendes, Luiz Ricardo A. Uchoa, Michael Berk, Michael Maes, Zafiris J. Daskalakis, Sophia Frangou, Michele Fornaro, Eduard Vieta, Brendon Stubbs, Marco Solmi, Andre F. Carvalho
Summary: Neuroimaging studies on individuals at genetic or clinical high risk for psychosis or bipolar disorder have uncertain findings. A meta-analytic review of whole-brain voxel-based morphometry and functional magnetic resonance imaging studies identified several results, including lower gray matter volumes in certain brain regions for genetic or clinical high-risk subjects, as well as reductions in gray matter and hypoactivation in specific brain areas for individuals at clinical high risk. Further neuroimaging studies are needed to investigate individuals with genetic or clinical high-risk bipolar disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Claudia Barth, Stener Nerland, Ann-Marie G. de Lange, Laura A. Wortinger, Eva Hilland, Ole A. Andreassen, Kjetil N. Jorgensen, Ingrid Agartz
Summary: Abnormalities in amygdala volume are frequently seen in schizophrenia and bipolar disorders. Patients with schizophrenia tend to have smaller amygdala volumes compared to healthy controls, particularly in certain nuclei like the basal nucleus.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Sean P. Carruthers, Philip Sumner, Matthew Hughes, Melissa J. Green, Christos Pantelis, Katherine E. Burdick, Vanessa Cropley, Tamsyn E. Van Rheenen
Summary: The study found that cross-diagnostic cognitive subgroups of individuals with SSD and BD did not appear to be clearly distinguished by patterns in brain morphology, with only some differences evident in specific brain regions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Clinical
D. P. Devanand, Dilip V. Jeste, T. Scott Stroup, Terry E. Goldberg
Summary: Late-onset psychosis is distressing and difficult to diagnose and treat effectively, with various underlying causes. This overview covers the epidemiology, clinical features, neurobiology, and therapeutics of late-onset psychoses.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Geriatrics & Gerontology
Paola Lavin, Gabriella Buck, Osvaldo P. Almeida, Chien-Lin Su, Lisa T. Eyler, Annemieke Dols, Hilary P. Blumberg, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Benoit H. Mulsant, Shang-Ying Tsai, Eduard Vieta, Sigfried Schouws, Farren B. S. Briggs, Ashley Sutherland, Kaylee Sarna, Joy Yala, Melis Orhan, Nicole Korten, Martha Sajatovic, Soham Rej
Summary: Late-onset bipolar disorder (LOBD) and early-onset bipolar disorder (EOBD) show no significant differences in terms of depression, mania, functionality, and employment status. However, LOBD is associated with higher endocrine comorbidities.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Health Care Sciences & Services
Lorenzo Moccia, Georgios D. Kotzalidis, Giovanni Bartolucci, Sara Ruggiero, Laura Monti, Marco Biscosi, Beatrice Terenzi, Ottavia M. Ferrara, Marianna Mazza, Marco Di Nicola, Delfina Janiri, Alessio Simonetti, Emanuele Caroppo, Luigi Janiri, Gabriele Sani
Summary: Psychosis is a complex condition characterized by delusions, hallucinations, and disorganized thought, speech, or behavior. There is increasing concern about the potential link between COVID-19 and the development of new-onset psychosis. This article reviews the current evidence on the association between SARS-CoV-2 and the risk of psychosis as an acute or post-infectious manifestation of COVID-19. It also discusses the challenges in determining a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Lisa Rauer, Sarah Trost, Aleksandra Petrovic, Oliver Gruber
Summary: Patients with bipolar disorder and schizophrenia exhibit distinct neural activation patterns in certain brain regions, with bipolar patients demonstrating specific hyperactivation in frontal and parietal areas compared to schizophrenia patients and healthy controls. Moreover, during more demanding cognitive tasks, both patient groups show hypoactivations in certain frontal areas and the ventral pathway.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Mirona Letitia Dobri, Alexandre Paim Diaz, Sudhakar Selvaraj, Joao Quevedo, Consuelo Walss-Bass, Jair C. Soares, Marsal Sanches
Summary: Schizophrenia and bipolar disorder share many similarities in terms of their premorbid course, clinical profile, genetic factors and treatment approaches. Neuroimaging studies show that they both involve structural changes and functional dysconnectivity in critical brain regions, suggesting a continuum between these two disorders.
BEHAVIORAL SCIENCES
(2022)
Article
Psychology, Clinical
Shinsuke Koike, Eisuke Sakakibara, Yoshihiro Satomura, Hanako Sakurada, Mika Yamagishi, Jun Matsuoka, Naohiro Okada, Kiyoto Kasai
Summary: This study reveals a robust relationship between prefrontal function and behavioral outcomes across three major psychiatric disorders through a large-sample neuroimaging study.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Laura Orsolini, Giulia Menculini, Silvia Tempia Valenta, Michele Fiorani, David Rocchetti, Virginio Salvi, Alfonso Tortorella, Umberto Volpe
Summary: This exploratory study investigated the psychopathological and temperamental features of late-onset bipolar disorder (LOBD) and non-late-onset bipolar disorder (non-LOBD). The results showed that LOBD was significantly associated with a higher rate of bipolar disorder II diagnosis, depressive episodes, mixed states, and predominant depressive and anxious affective temperaments. On the other hand, non-LOBD was significantly associated with higher rates of endocrinological and metabolic comorbidity, bipolar disorder I diagnosis, manic episodes, and predominant hyperthymic affective temperaments.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Niccolo Zovetti, Maria Gloria Rossetti, Cinzia Perlini, Paolo Brambilla, Marcella Bellani
Summary: This study found neuroimaging evidence suggesting a link between bipolar disorder (BD) and neurodegenerative processes. It showed a progressive reduction in gray matter volume throughout the whole brain, as well as changes in deep brain structures and prefrontal regions. BD patients also exhibited larger gaps between predicted and chronological brain age compared to normal aging. Further systematic reviews and meta-analyses are needed to quantify the impact of brain aging-related effects in BD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)