Article
Genetics & Heredity
Fengchao Zhang, Yao Chen, Jie Shen, Junzheng Zhang
Summary: The Notch signaling pathway plays crucial roles in animal development, with protein ubiquitination regulating the stability and activity of major signaling components. Multiple ubiquitin ligases and deubiquitinating enzymes have been identified in Drosophila that modify Notch ligand and receptor proteins. UbcD1 has been found to be required for Notch signaling activation during Drosophila wing development, suggesting a novel role for UbcD1 in development.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Sun-Jie Chen, Jin-Li Zhang, Wen-Jing Ma, Hui-Jie Wu, Yang Li, Xing-Xing Shen, Hai-Jun Xu
Summary: In this study, the zinc finger transcription factor rotund was identified as a potential regulator of wing-morph in insects. Through transcriptomic analysis and phenotypic screening, it was found that rotund physically interacts with FoxO to regulate the development of wings.
Article
Entomology
Do-Hwan Lim, Min-Seok Choi, Ji Won Jeon, Young Sik Lee
Summary: The miR-252-5p-Rab6 regulatory axis controls the Notch signaling pathway in Drosophila wing development. The loss of miR-252 increases wing size, while its overexpression leads to patterning defects in adult wings. The overexpression-induced wing phenotypes are caused by aberrant Notch signaling and intracellular accumulation of full-length Notch receptor, possibly due to defects in intracellular trafficking and autophagy-mediated degradation.
Article
Genetics & Heredity
Bipin Kumar Tripathi, Kenneth D. Irvine
Summary: The Drosophila wing imaginal disc is a crucial tissue for research in animal development, providing a valuable system for genetic studies and understanding various biological processes.
Article
Entomology
Wen-Min Fan, Dan Luo, Jun-Zheng Zhang, Dan Wang, Jie Shen
Summary: The Drosophila vestigial (vg) gene plays a key role in wing imaginal disc cell proliferation and can block cell migration induced by loss of Dpp or Wg signaling. Additionally, c-Jun N-terminal kinase (JNK) signaling promotes cell migration induced by vg suppression by upregulating Caspase activity. Overall, these findings highlight the importance of Vg in suppressing cell migration and how developmental signals collaborate to stabilize cells along the compartment boundary.
Article
Developmental Biology
Julia Falo-Sanjuan, Sarah J. Bray
Summary: The Notch pathway mediates cell-to-cell communication and its activation relies on the interaction between transmembrane ligands and receptors on adjacent cells. In Drosophila embryos, Notch signaling initiation is correlated with the formation of lateral membranes and adherens junctions, with the latter playing a crucial role in modulating Notch activity.
Article
Biochemistry & Molecular Biology
Ioannis Nellas, K. Venkatesan Iyer, Juan M. Iglesias-Artola, Martin Pippel, Andre Nadler, Suzanne Eaton, Natalie A. Dye
Summary: The production and utilization of ATP play a crucial role in animal development. Researchers used a FRET-based sensor to monitor ATP levels in the developing tissue of Drosophila larvae and found spatial differences in metabolic behavior. The Hedgehog signaling pathway was identified as a regulator of ATP production through glycolysis. These findings enhance our understanding of the connection between developmental patterning genes and ATP production during animal tissue development.
Article
Biochemistry & Molecular Biology
Anja C. Nagel, Dominik Mueller, Mirjam Zimmermann, Anette Preiss
Summary: The membrane-bound Notch regulator (Mnr) supports Notch signaling by promoting the cleavage of the Notch receptor, which in turn enhances Notch receptor activation. Overexpression of Mnr stimulates γ-secretase activity, while knockdown of Mnr inhibits this activity, demonstrating Mnr as a positive regulator of Notch signaling.
Article
Biochemistry & Molecular Biology
Rui Wang, Hao Xie, Lin Yang, Ping Wang, Meng-Meng Chen, Hong-Yan Wu, Yan-Lin Liao, Ming-Ying Wang, Qiang Wang, Xiao-Xia Gong, Qian Cheng, Lin Cheng, Fei-Yan Xie, Cai-Li Bi, Ming Fang
Summary: The study shows that nkd plays an important role in wing pattern formation in fruit flies, with both gain and loss of nkd resulting in disrupted Wg target gene expression and abnormal adult wing morphologies. A thirty amino acid fragment in Nkd is critical for canonical Wg signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Developmental Biology
Olga Zaytseva, Naomi C. Mitchell, Damien Muckle, Caroline Delandre, Zuqin Nie, Janis K. Werner, John T. Lis, Eduardo Eyras, Ross D. Hannan, David L. Levens, Owen J. Marshall, Leonie M. Quinn
Summary: FUBP1 and Psi, members of the FUSE Binding Protein family, regulate gene transcription by binding to single-stranded DNA and RNA, promoting cell growth and division. Psi activates Myc and stg to promote cell proliferation, while repressing the transcription of tok, a growth inhibitor.
Review
Cell Biology
Abhinava K. Mishra, Vartika Sharma, Mousumi Mutsuddi, Ashim Mukherjee
Summary: Multicellular organisms rely on core signaling pathways to regulate cell fate choices, which integrate to form complex networks for distinct developmental outcomes. Notch pathway, a conserved mechanism, interacts with other pathways to produce context-dependent outputs, and understanding its crosstalk with JNK and NF-KB pathways is crucial for regulating various developmental events.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Lisa Frankenreiter, Bernd M. Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C. Nagel
Summary: The study reveals a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors in the DNA-binding domain. Findings in fruit flies and mammalian cells suggest a potential conservation of this phosphorylation regulatory mechanism, providing a means to fine-tune Notch signal transduction in a context-dependent manner.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Paul C. Marcogliese, Debdeep Dutta, Shrestha Sinha Ray, Nghi D. P. Dang, Zhongyuan Zuo, Yuchun Wang, Di Lu, Fatima Fazal, Thomas A. Ravenscroft, Hyunglok Chung, Oguz Kanca, JiJun Wan, Emilie D. Douine, Undiagnosed Diseases Network, Loren D. M. Pena, Shinya Yamamoto, Stanley F. Nelson, Matthew Might, Kathrin C. Meyer, Nan Cher Yeo, Hugo J. Bellen
Summary: Truncation of IRF2BPL leads to severe childhood-onset neurodegenerative disorders. Through studies in Drosophila and zebrafish, it has been found that IRF2BPL can repress Wnt transcription, and dysregulation of Wnt signaling is associated with neural dysfunction and axonal loss.
Article
Genetics & Heredity
Jacob Klemm, Michael J. Stinchfield, Robin E. Harris
Summary: Regeneration is a complex process that requires a coordinated genetic response to tissue loss. Necrosis can stimulate regeneration at an equivalent level to apoptosis, but also results in significant apoptosis far from the site of ablation, termed necrosis-induced apoptosis (NiA). This programmed cell death at a distance from the injury promotes regeneration by limiting proliferation.
Article
Biology
Elizabeth Diaz-Torres, Luis Manuel Munoz-Nava, Marcos Nahmad
Summary: A study on fruit fly wings reveals that variations in cell proliferation rates are inversely proportional to the duration of cell recruitment. Undifferentiated cells may be responsible for driving the proliferation of wing-committed cells. The duration of cell recruitment robustly determines the final size of the wings.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
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Multidisciplinary Sciences
Shanshan He, Zhen Zhao, Yongfei Yang, Douglas O'Connell, Xiaowei Zhang, Soohwan Oh, Binyun Ma, Joo-Hyung Lee, Tian Zhang, Bino Varghese, Janae Yip, Sara Dolatshahi Pirooz, Ming Li, Yong Zhang, Guo-Min Li, Sue Ellen Martin, Keigo Machida, Chengyu Liang
NATURE COMMUNICATIONS
(2015)
Editorial Material
Cell Biology
Yongfei Yang, Christine Quach, Chengyu Liang
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Biochemistry & Molecular Biology
Yongfei Yang, Shanshan He, Qiaoxiu Wang, Fan Li, Mi-Jeong Kwak, Sally Chen, Douglas O'Connell, Tian Zhang, Sara Dolatshahi Pirooz, YongHeui Jeon, Nyam-Osor Chimge, Baruch Frenkel, Younho Choi, Grace M. Aldrovandi, Byung-Ha Oh, Zengqiang Yuan, Chengyu Liang
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Biochemistry & Molecular Biology
Meiying Luo, Longfei Wu, Kexin Zhang, Hong Wang, Tian Zhang, Lucas Gutierrez, Douglas O'Connell, Peng Zhang, Yu Li, Tongtong Gao, Wenyan Ren, Yongfei Yang
CELL DEATH AND DIFFERENTIATION
(2018)
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Cell Biology
Meiying Luo, Longfei Wu, Kexin Zhang, Hong Wang, Sharon Wu, Douglas O'Connell, Tongtong Gao, Hanbing Zhong, Yongfei Yang
CELLULAR SIGNALLING
(2018)
Editorial Material
Cell Biology
Shanshan He, Douglas O'Connell, Xiaowei Zhang, Yongfei Yang, Chengyu Liang
Editorial Material
Cell Biology
Sara Pirooz, Shanshan He, Douglas O'Connell, Payam Khalilzadeh, Yongfei Yang, Chengyu Liang
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Cell Biology
Lei Gao, Xiaomeng Hou, Longfei Wu, Feifei Zhang, Qinghai Zhang, Xiaolei Ye, Yongfei Yang, Xinhua Lin
CELLULAR SIGNALLING
(2013)
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Developmental Biology
Dong Yan, Yihui Wu, Yongfei Yang, Tatyana Y. Belenkaya, Xiaofang Tang, Xinhua Lin
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Developmental Biology
Lei Gao, Longfei Wu, Xiaomeng Hou, Qinghai Zhang, Feifei Zhang, Xiaolei Ye, Yongfei Yang, Xinhua Lin
DEVELOPMENTAL BIOLOGY
(2013)
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Biochemistry & Molecular Biology
Kexin Zhang, Longfei Wu, Peng Zhang, Meiying Luo, Jing Du, Tongtong Gao, Douglas O'Connell, Gaoyang Wang, Hong Wang, Yongfei Yang
MOLECULAR CARCINOGENESIS
(2018)
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Multidisciplinary Sciences
Yongfei Yang, Gyu-beom Jang, Xuanjun Yang, Qiaoxiu Wang, Shanshan He, Shun Li, Christine Quach, Shihui Zhao, Fan Li, Zengqiang Yuan, Hye-Ra Lee, Hanbing Zhong, Chengyu Liang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O' Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang, Wei Chen
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Ying Zhang, Meiying Luo, Xiaohong Cui, Douglas O'Connell, Yongfei Yang
Summary: This study reveals the important role of NEAT1 in regulating ferroptosis in tumors, and enhances the effect of ferroptosis by modulating miR-362-3p and MIOX. Therefore, ferroptosis induction may be a promising therapeutic strategy for HCC patients with high NEAT1 expression.
CELL DEATH AND DIFFERENTIATION
(2022)