Journal
JOURNAL OF GENETICS AND GENOMICS
Volume 38, Issue 7, Pages 279-288Publisher
SCIENCE PRESS
DOI: 10.1016/j.jgg.2011.06.001
Keywords
Evo-Devo; Transcription regulation; Rewiring; Reprogramming; Molecular evolution
Funding
- Ministry of Science and Technology of China [2011CB100700]
- National Natural Science Foundation of China [30771401, 31070081]
- Institute of Microbiology, Chinese Academy of Sciences
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Rewiring and reprogramming of transcriptional regulation took place during bacterial speciation. The mechanistic alterations among transcription factors, cis-regulatory elements and target genes confer bacteria novel ability to adapt to stochastic environmental changes. This process is critical to their survival, especially for bacterial pathogens subjected to accelerated evolution. In the past two decades, the investigators not only completed the sequences of numerous bacterial genomes, but also made great progress in understanding the molecular basis of evolution. Here we briefly reviewed the current knowledge on the mechanistic changes among orthologous, paralogous and xenogenic regulatory circuits, which were caused by genetic recombinations such as gene duplication, horizontal gene transfer, transposable elements and different genetic contexts. We also discussed the potential impact of this area on theoretical and applied studies of microbes.
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