Article
Psychiatry
Iau-Jin Lin, Nian-Sheng Tzeng, Chi-Hsiang Chung, Wu-Chien Chien
Summary: The study found an association between female patients with psychosexual disorders and the risk of developing psychiatric disorders, emphasizing the importance for clinicians to pay attention to the mental health issues in these patients.
Review
Biochemistry & Molecular Biology
Daniela Navarro, Ani Gasparyan, Francisco Navarrete, Abraham B. Torregrosa, Gabriel Rubio, Marta Marin-Mayor, Gabriela B. Acosta, Maria Salud Garcia-Gutierrez, Jorge Manzanares
Summary: This article reviews the molecular alterations in the endocannabinoid system (ECS) in different psychiatric disorders and highlights the urgent need for clinical research to identify ECS alterations as potential biomarkers and design new therapeutic targets for improved treatment in psychiatry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhao Zhang, Jian Zhang, Lixia Diao, Leng Han
Summary: Small non-coding RNAs play critical roles in cancer development and have the potential to be biomarkers and therapeutic targets. Recent research has focused on four sncRNA species in cancer and their functional significance, highlighting their potential utility as prognostic and diagnostic biomarkers.
Review
Biochemistry & Molecular Biology
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Psychiatric disorders are prevalent brain pathologies. Reliable animal models are needed for effective treatment. Zebrafish show complex behaviors similar to rodents and humans, making them suitable for modeling psychiatric disorders. However, there are challenges and the field needs further discussion and consideration of clinical prevalence and pathological complexity. Recent developments in molecular biology might pave the way for wider use of zebrafish in CNS disease modeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kaori Futaba, Ssu-Chi Chen, Wing Wa Leung, Cherry Wong, Tony Mak, Simon Ng, Hans Gregersen
Summary: This study used a simulated stool called Fecobionics to study different defecation patterns in fecal incontinence patients and compared defecation indices between passive and urge incontinent patients. The results showed that Fecobionics data had higher correlation with symptoms in fecal incontinence patients and provided DI data that cannot be obtained with ARM-BET.
SCIENTIFIC REPORTS
(2022)
Review
Psychology, Clinical
Xiao Chang, Qiyong Gong, Chunbo Li, Weihua Yue, Xin Yu, Shuqiao Yao, Jianfeng Feng
Summary: China accounts for 17% of the global disease burden attributable to mental, neurological and substance use disorders. Progress in neuroscience research and clinical services for psychiatric disorders in China during the past three decades is reviewed, highlighting contributions from studies in epidemiological, genetic, and neuroimaging fields, as well as advancements in large-scale imaging genetic cohorts and brain banks. Opportunities and challenges in research and clinical services are discussed, emphasizing the importance of continued funding investment and international collaborations for sustained advancement in psychiatric research and healthcare system in China.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Yiming Jia, Li Hui, Lulu Sun, Daoxia Guo, Mengyao Shi, Kaixin Zhang, Pinni Yang, Yu Wang, Fanghua Liu, Ouxi Shen, Zhengbao Zhu
Summary: Using Mendelian randomization design, this study identified eight blood metabolites associated with psychiatric disorders, including five established mediators and three novel mediators. Additional effects on nonpsychiatric diseases were observed for most of the identified metabolites, except for a few. Notably, four metabolites showed no adverse side effects.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Bruno Romeo, Marianne Hermand, Amelie Petillion, Laurent Karila, Amine Benyamina
Summary: The intensity of the acute psychedelic experience was found to be the main predicting factor of response in all psychiatric and addictive disorders studied, suggesting a potential mechanism involving modulation of the serotoninergic system, default mode network (DMN) disintegration and re-integration, or anti-inflammatory effects.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Health Care Sciences & Services
Laetitia Leveque, Stavroula Papadodima, Ryan Toutin, Mathieu Fraigneau, Eric Baccino, Laurent Martrille
Summary: The aim of this study was to determine the prevalence of domestic violence among patients attending a French psychiatric emergency department and its association with psychiatric disorders. A retrospective study was conducted, including all patients examined in the department from July 1, 2021, to October 31, 2021. The prevalence of domestic violence was 38.2%, with a higher percentage among female victims compared to male victims. Psychological abuse was reported by 20.7% of the victims, physical abuse by 17.2%, sexual abuse by 3.4%, and multiple forms of abuse by 58.6%. The risk of suicide attempt and anxiety disorder was associated with domestic violence among female patients.
Article
Psychiatry
Natalie Laporte, Andrejs Ozolins, Sofie Westling, Asa Westrin, Marta Wallinius
Summary: Self-harm, including non-suicidal self-injury and suicide attempts, is prevalent among forensic psychiatric patients, with common methods such as head banging or cutting. The main functions of self-harm include affect regulation, self-punishment, and marking distress. Self-harm is associated with neurodevelopmental disorders and disruptive impulse-control and conduct disorders in this group.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Andrea Aguglia, Giovanni Pietro Corsini, Alessandra Costanza, Andrea Berti, Edoardo Bruno, Andrea Escelsior, James Sanvi, Alice Trabucco, Eleonora Vai, Andrea Amerio, Gianluca Serafini, Mario Amore
Summary: The aim of this study is to identify the main sociodemographic and clinical correlates associated with frequent service users (FSUs) in an Italian psychiatric emergency department. The results showed that FSUs were more likely to be single, younger, with an earlier onset, and have a longer length of hospitalisation compared to non-FSUs. They were also more prone to bipolar disorder, cluster B personality disorder, substance use disorder, and non-suicidal self-injuries. Furthermore, FSUs were more likely to be discharged against medical advice or have escape attempts from the psychiatric ward.
Article
Multidisciplinary Sciences
Matej Stuhec, Valentina Tement
Summary: The study found that including a clinical pharmacist in interdisciplinary ward rounds at psychiatric hospitals can significantly reduce both expressed and potential drug-related issues, with a high rate of recommendation acceptance.
SCIENTIFIC REPORTS
(2021)
Review
Psychiatry
Ashley N. Siegel, Shakila Meshkat, Katie Benitah, Orly Lipsitz, Hartej Gill, Leanna M. W. Lui, Kayla M. Teopiz, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This paper summarizes and analyzes 70 registered clinical studies on clinicaltrials.gov that evaluate the treatment of psychiatric disorders with psychedelics, with the majority focusing on investigating the therapeutic effects of MDMA and psilocybin, especially for PTSD and MDD. Ongoing studies on psychedelics highlight the importance of considering relevant research priorities for future proposed studies by researchers and stakeholders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Behavioral Sciences
A. Khayachi, L. Schorova, M. Alda, G. A. Rouleau, A. J. Milnerwood
Summary: The effectiveness and mode of action of lithium treatment for neurological conditions remains not fully understood, although studies have shown its impact on protein posttranslational modifications and neuronal physiology. Determining specific posttranslational modification patterns could be a promising strategy to develop disease biomarkers and predict lithium responsiveness.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yan Xia, Rujia Dai, Kangli Wang, Chuan Jiao, Chunling Zhang, Yuchen Xu, Honglei Li, Xi Jing, Yu Chen, Yi Jiang, Richard F. Kopp, Gina Giase, Chao Chen, Chunyu Liu
Summary: The study expanded the regulatory networks related to sex-differential methylation and psychiatric disorders by integrating methylation quantitative trait loci, gene expression, and protein-protein interaction data. It found significant enrichment of sex-associated genes in psychiatric disorder-associated gene sets, suggesting that sex-differential genes in neuronal pathways may contribute to the sex-bias of psychiatric disorders.
MOLECULAR PSYCHIATRY
(2021)
