Review
Oncology
Sophie Grabar, Dominique Costagliola
Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.
Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Xiaohong Kong, Dongmei Li, Amirsalar Mansouri, Guobin Kang, Khalid Sayood, John West, Charles Wood
Summary: Our study highlights the unique cellular responses of neuronal SH-SY5Y cells to KSHV infection, showing higher growth rates and a transition between latent and lytic phases. Unlike other infected cells, neuronal cells express both latent and some lytic genes. These alterations may contribute to sustaining cell growth and providing growth advantages for the cells during KSHV infection, potentially playing a role in neuronal disease development.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Article
Virology
Mariel Kleer, Grant MacNeil, Nancy Adam, Eric S. Pringle, Jennifer A. Corcoran
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) expresses high levels of the kaposin transcript during both latent and lytic phases of replication. Previous reagents did not allow for methodical analysis of individual kaposin proteins in KSHV replication. This study created a panel of mutant viruses and cell lines that delete kaposin proteins individually or in combination, enabling precise analysis of their roles in KSHV replication. The findings provide molecular tools for further research on the contributions of kaposin proteins in KSHV infection.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Yuki Iwaisako, Tadashi Watanabe, Manami Futo, Rimiko Okabe, Yuichi Sekine, Youichi Suzuki, Takashi Nakano, Masahiro Fujimuro
Summary: In the process of KSHV capsid formation, ORF7 plays a role in capsid maturation and its zinc-finger motif is essential for TR cleavage and virus production in the KSHV genome.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.
Article
Biochemistry & Molecular Biology
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Summary: In this study, ribozymes derived from RNase P catalytic RNA were engineered to target the mRNA encoding KSHV RTA. The functional ribozyme F-RTA efficiently sliced the RTA mRNA and suppressed KSHV production and gene expression. This study demonstrates the potential of RNase P ribozymes as a therapy against KSHV.
Article
Biology
Jungang Chen, Lu Dai, Lindsey Barrett, Jennifer James, Karlie Plaisance-Bonstaff, Steven R. Post, Zhiqiang Qin
Summary: The study reveals that SARS-CoV-2 encoded proteins and some anti-COVID-19 drugs can induce lytic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV), increasing the risk of virus-associated cancers for KSHV-positive patients exposed to COVID-19 or undergoing its treatment, even after they have fully recovered from COVID-19.
COMMUNICATIONS BIOLOGY
(2021)
Article
Infectious Diseases
Jinchuan Shi, Gaoxiang Ying, Zhongdong Zhang
Summary: In the treatment of AIDS patients with Kaposi's sarcoma, the reconstitution of immune function and consecutive chemotherapy with doxorubicin liposome are crucial. Early recognition and histopathological verification of general symptoms such as thrombocytopenia and hemorrhagic purple papules in AIDS patients are necessary to achieve early diagnosis of KS and timely clinical intervention.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Oncology
Vickie A. Marshall, Nicholas C. Fisher, Charles A. Goodman, Elena M. Cornejo Castro, Isabella Liu, Sirish Khanal, Benjamin M. Holdridge, Abigail L. Thorpe, Nazzarena Labo, Kristen B. Stolka, Jennifer J. Hemingway-Foday, Mahamat Abassora, Paul N'Dom, Jennifer S. Smith, Neneh Sallah, Anne L. Palser, Paul Kellam, Brandon F. Keele, Denise Whitby
Summary: In sub-Saharan Africa, the endemicity of Kaposi's sarcoma-associated herpesvirus (KSHV) and the resulting Kaposi's sarcoma (KS) pose significant public health challenges. This study conducted near full-length KSHV genome sequence analysis on samples from individuals in Cameroon, revealing unique polymorphisms, genotypic diversity, and evidence of recombination. However, no correlation was found between viral sequence variations and disease. This is the first study to systematically compare near full-length KSHV genome sequences between KS cases and controls in the same region.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Hematology
Camille Rasmussen, Laurence Gerard, Jehane Fadlallah, Emilie Corvilain, Lionel Galicier, Veronique Meignin, Eric Oksenhendler, David Boutboul
Summary: This retrospective study analyzed the treatment outcome of 99 HHV8(+) MCD patients with rituximab-based therapy. The study found that HIV- status, high HHV8 viral load, and elevated serum CRP levels were independent risk factors for disease progression after rituximab-induced complete remission. The study also suggested that HIV+ patients had a lower progression rate, possibly due to immune restoration upon antiretroviral therapy.
Review
Virology
Hosni A. M. Hussein, Lia R. Walker, Usama M. Abdel-Raouf, Sayed A. Desouky, Abdel Khalek M. Montasser, Shaw M. Akula
ARCHIVES OF VIROLOGY
(2015)
Article
Oncology
Hosni A. M. Hussein, Lia R. Walker, Shaw M. Akula
Article
Biochemistry & Molecular Biology
Lia R. Walker, Hosni A. M. Hussein, Shaw M. Akula
CELL AND BIOSCIENCE
(2016)
Article
Virology
Hosni A. M. Hussein, Usama M. Abdel-Raouf, Shaw M. Akula
Article
Multidisciplinary Sciences
Hosni A. M. Hussein, Shaw M. Akula
SCIENTIFIC REPORTS
(2017)
Review
Virology
Hosni A. M. Hussein, Ikenna B. Okafor, Lia R. Walker, Usama M. Abdel-Raouf, Shaw M. Akula
ARCHIVES OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Hosni A. M. Hussein, Katarina Briestenska, Jela Mistrikova, Shaw M. Akula
SCIENTIFIC REPORTS
(2018)
Review
Virology
Hosni A. M. Hussein, Mohammad A. Alfhili, Pranaya Pakala, Sandra Simon, Jaffer Hussain, James A. McCubrey, Shaw M. Akula
Article
Biochemistry & Molecular Biology
Mohammad A. Alfhili, Hosni A. M. Hussein, Youngyong Park, Myon Hee Lee, Shaw M. Akula
Summary: This study investigates the antitumor properties of Triclosan (TCS) in Burkitt's lymphoma (BL) cells, showing that TCS induce cell death through various mechanisms such as membrane phospholipid scrambling, compromised permeability, and activation of caspase and JNK MAPK signaling pathways. This research identifies TCS as a potential antitumor agent with insights into its molecular mechanisms of action in BL cells.
Article
Immunology
Asmaa M. Zahran, Mona H. Abdel-Rahim, Khalid A. Nasif, Safinaz Hussein, Rania Hafez, Ahmad Bahieldeen Ahmad, Khaled Saad, Amira Elhoufey, Hosni A. M. Hussein, Ali A. Thabet, Omnia El-Badawy
Summary: This study aimed to investigate the levels of follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in COVID-19 patients and their correlation with disease severity and hyperglycemia. The results showed that COVID-19 is associated with increased activation of Tfh cells and decreased levels of Tfr cells, especially in severe and diabetic patients.
Article
Cell Biology
Mohamed A. A. Hussein, Hosni A. M. Hussein, Ali A. Thabet, Karim M. Selim, Mervat A. Dawood, Ahmed M. El-Adly, Ahmed A. Wardany, Ali Sobhy, Sameh Magdeldin, Aya Osama, Ali M. Anwar, Mohammed Abdel-Wahab, Hussam Askar, Elsayed K. Bakhiet, Serageldeen Sultan, Amgad A. Ezzat, Usama Abdel Raouf, Magdy M. Afifi
Summary: The study found that human Wharton's jelly MSC secretome (hWJ-MSC-S) has strong antiviral potential against SARS-CoV-2 and IBV infections, and revealed the mechanism by which it inhibits viral infection. These findings suggest that hWJ-MSC-S could be used in future research to develop effective therapeutic approaches.
Article
Microbiology
Hajir A. Al Saihati, Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Sabry Y. Mahmoud, Eman S. Farrag, Taha I. A. Mohamed, Samah M. Fathy, Mohamed E. Elnosary, Ali Sobhy, Abdelazeem E. Ahmed, Ahmed M. El-Adly, Fareed S. El-Shenawy, Asmaa A. Elsadek, Amal Rayan, Zeinab Albadry M. Zahran, Omnia El-Badawy, Mohamed G. M. El-Naggar, Magdy M. Afifi, Asmaa M. Zahran
Summary: This study identified alterations in memory T cells among COVID-19 patients, revealing a sex bias in the percentage of memory T cells. Moreover, COVID-19 severity and comorbidities have been linked to specific subsets of T memory cells which could be used as therapeutic, diagnostic, and protective targets for severe COVID-19.
Article
Virology
Hosni A. M. Hussein, Shaw M. Akula
ARCHIVES OF VIROLOGY
(2017)