Review
Urology & Nephrology
Zhenlang Guo, Junwei He, Lijuan Huang, Zhaohui Wang, Ping Hu, Shusheng Wang, Zunguang Bai, Jun Pan
Summary: This study aimed to explore the prevalence and clinical risk factors of incidental prostate cancer (IPC) in patients diagnosed with benign prostatic hyperplasia (BPH) who underwent transurethral resection of the prostate (TURP), open prostatectomy (OP), or holmium laser enucleation of the prostate (HoLEP). The results showed that the prevalence of IPC was similar among the three surgical treatments, and an increased PSA level was the only independent predictor of IPC.
INTERNATIONAL BRAZ J UROL
(2022)
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Article
Reproductive Biology
Michal Wieszczeczy, Leszek Krakowski, Grzegorz Opielak, Izabela Krakowska, Jacek Furmaga, Piotr Brodzki, Mariola Bochniarz, Roman Dabrowski, Tomasz Piech, Barbara Zdzisinska, Lukasz Adaszek
Summary: The study confirmed the significant role of miRNA-129 and VEGF in diagnosing BPH in dogs, helping differentiate dogs with BPH and contribute to the diagnosis of prostate disorders.
Article
Chemistry, Medicinal
Liping Wang, Yiwen Hou, Rong Wang, Qi Pan, Debao Li, Han Yan, Zuyue Sun
Summary: This study found that astaxanthin (AST) may have an inhibitory effect on testosterone-induced benign prostatic hyperplasia in rats by regulating superoxide dismutase (SOD) activity and testosterone (T) and dihydrotestosterone (DHT) levels.
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Review
Biochemistry & Molecular Biology
Jiang Liu, Junchao Zhang, Xun Fu, Shu Yang, Yan Li, Jianmin Liu, Michael E. DiSanto, Ping Chen, Xinhua Zhang
Summary: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, characterized by prostatic enlargement and lower urinary tract symptoms (LUTs). Pathological processes of prostate hyperplasia are related to cell proliferation and apoptosis imbalance, inflammation, epithelial-mesenchymal transition (EMT) and growth factors. Cell adhesion molecules (CAMs), such as integrins and cadherins, play important roles in both physiological and pathological processes of BPH. Targeting CAMs may have potential therapeutic value for BPH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Renato Bueno Flores, Daniel de Souza Ramos Angrimani, Maira Morales Brito, Leticia Lima de Almeida, Joao Vitor Menezes Lopes, Joao Diego de Agostini Losano, Camila Infantosi Vannucchi
Summary: Benign Prostatic Hyperplasia (BPH) directly affects the reproductive potential of senile dogs by causing prostate enlargement and sperm injury. The effects of finasteride treatment on sperm samples submitted to cryopreservation are unknown. This study evaluated frozen-thawed semen of BPH dogs and dogs treated with finasteride. Finasteride-treated dogs showed increased spermatozoa functional performance, suggesting their potential use as semen donors in sperm cryopreservation programs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Jinhua He, Zeping Han, Wenfeng Luo, Jian Shen, Fangmei Xie, Liyin Liao, Ge Zou, Xin Luo, Zhonghui Guo, Yuguang Li, Jianhao Li, Hanwei Chen
Summary: Serum organic acid metabolites can be used as biomarkers to differentiate prostatitis, BPH, and PCa, as identified through LC-MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Lenah S. Binmahfouz, Haifa Almukadi, Abdulmohsin J. Alamoudi, Ali M. El-Halawany, Hossam M. Abdallah, Mardi M. Algandaby, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Faraj A. Alghamdi, Majed Al-Shaeri, Ashraf B. Abdel-Naim
Summary: The study found that 6-PD could inhibit testosterone-induced BPH in rats and has anti-proliferative, antioxidant, and anti-inflammatory properties, as well as the ability to inhibit activation of the AKT/mTOR axis.
Article
Medicine, Research & Experimental
Haifa Almukadi, Basma G. Eid, Rasheed A. Shaik, Ashraf B. Abdel-Naim, Ahmed Esmat
Summary: Auraptene-NLC demonstrates protective effects against BPH in rats induced by testosterone, through its anti-inflammatory, antioxidant, and proapoptotic activities, as well as PPAR family activation. The drug alleviates prostatic hyperplasia and oxidative stress, improves prostate tissue structure, and regulates the expression of apoptosis and inflammatory factors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Wei-Syun Hu, Cheng-Li Lin
Summary: This study investigated the incidence of benign prostatic hyperplasia (BPH) following a diagnosis of carpal tunnel syndrome or trigger finger. The results showed an increased risk of developing BPH in patients with carpal tunnel syndrome, trigger finger, and both conditions.
Article
Pharmacology & Pharmacy
Abdulmohsin J. Alamoudi, Sami A. Alessi, Waleed Y. Rizg, Abdulmajeed M. Jali, Awaji Y. Safhi, Fahad Y. Sabei, Sameer Alshehri, Khaled M. Hosny, Ashraf B. Abdel-Naim
Summary: This study found that cordycepin has the ability to prevent testosterone-induced benign prostatic hyperplasia (BPH) in rats. It exerts its effects through its antiproliferative, antioxidant, anti-inflammatory, pro-apoptotic actions, and modulation of AMPK and AKT activation.
Article
Cell Biology
Yi-Yi Wang, Kun Xia, Zhen-Xing Wang, Hui Xie, Ran Xu
Summary: The study found that osteocytes promote the development of benign prostatic hyperplasia (BPH) by secreting exosomes, providing a new mechanism for communication between bone and prostate.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Immunology
Dehong Cao, Ruonan Sun, Lei Peng, Jinze Li, Yin Huang, Zeyu Chen, Bo Chen, Jin Li, Jianzhong Ai, Lu Yang, Liangren Liu, Qiang Wei
Summary: This article provides a comprehensive review of the role of inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH). Inflammation plays a significant role in the occurrence and development of BPH, and its mechanisms include tissue damage, autoimmunity, and interaction with androgens. Early intervention in prostate tissue inflammation during treatment can slow down the progression of BPH, and combining standard therapies with anti-inflammatory measures may offer new insights for BPH treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Junya Hata, Yuki Harigane, Kanako Matsuoka, Hidenori Akaihata, Kei Yaginuma, Satoru Meguro, Seiji Hoshi, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima
Summary: Benign prostatic hyperplasia (BPH) is a chronic proliferative disease mainly characterized by stromal proliferation. Although aging and androgen have been considered risk factors, recent studies suggest the involvement of androgen-independent factors, such as inflammation, in BPH development. In this study, whole-genome gene expression analysis using a stromal-dominant BPH rat model revealed activated immune response-related pathways and complement classical pathways. Moreover, the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. Understanding the role of androgen-independent factors, like immune responses, contributes to unraveling the pathogenesis of BPH and may lead to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)