Article
Oncology
Ricardo J. Wray, Shannon E. Nicks, Prajakta Adsul, Michael Elliot, Kimberly Enard, Keri Jupka, Anna K. Trainer, Natasha Hansen, Mellve Shahid, Robin Wright-Jones, Sameer Siddiqui
Summary: This study evaluated the impact of an educational outreach program on the decision-making abilities of African American men regarding prostate cancer screening. The program successfully improved participants' knowledge, beliefs, attitudes, anxiety levels, and self-efficacy, ultimately leading to informed decision-making.
CANCER CAUSES & CONTROL
(2022)
Article
Medicine, General & Internal
Margaret S. Pichardo, Tsion Zewdu Minas, Catherine M. Pichardo, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Brid M. Ryan, Christopher A. Loffredo, Stefan Ambs
Summary: This study found that African American men living in deprived neighborhoods have a higher risk of prostate cancer and related mortality, potentially due to their systemic immune function and inflammation levels.
Article
Oncology
Xiaoyin Li, Siddhartha Roy, Jennifer Damonte, Hyun Y. Park, Aasha I. Hoogland, Kala Jamison, Khaled R. Komrokji, Chang Dong Yeo, Youngchul Kim, Jasreman Dhillon, Lisa M. Gudenkauf, Laura B. Oswald, Heather S. L. Jim, Kosj Yamoah, Julio M. Pow-Sang, Peter A. Kanetsky, Clement K. Gwede, Jong Y. Park, Brian D. Gonzalez
Summary: This study aimed to establish a state-wide biobank of African American prostate cancer survivors in Florida to identify biological bases for health disparities. African American men diagnosed with prostate cancer between 2013 and 2017 were identified through the State of Florida's cancer registry. Of the eligible and reachable individuals, a low overall consent rate of 10% was observed. Existing challenges limit the consent and participation in biospecimen research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Biology
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari
Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Joakin O. Mori, Jason White, Isra Elhussin, Babatunde M. Duduyemi, Balasubramanyam Karanam, Clayton Yates, Honghe Wang
Summary: This study identifies genes with high expression in African American prostate cancer patients, which are linked to oncogenic gene signatures and subtypes associated with poor prognosis. The findings help address biomarker bias in prostate cancer risk stratification and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Himali Gujrati, Siyoung Ha, Azah Mohamed, Bi-Dar Wang
Summary: This study suggests that differential miRNA-mRNA regulatory networks contribute to the disparities in prostate cancer (PCa) between African American (AA) and European American (EA) populations. The study identifies differential expression of miRNAs and mRNA pathways, particularly mTOR and VEGF signaling, in AA PCa compared to EA PCa. Further analysis reveals that certain miRNAs negatively regulate genes involved in PCa progression, providing potential targets for reducing PCa aggressiveness and chemoresistance in AA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Colleen M. McBride, Sarita Pathak, Courtney E. Johnson, Anthony J. Alberg, Elisa V. Bandera, Jill S. Barnholtz-Sloan, Melissa L. Bondy, Michele L. Cote, Patricia G. Moorman, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Joellen M. Schildkraut
Summary: The study found that only a minority of African American women participants underwent genetic testing, with lower income and experiencing job discrimination decreasing the likelihood of testing. The results support the need for interventions to improve the uptake of genetic testing among African American women by reducing cost barriers and providing assurances that genetic results will be kept private.
Review
Oncology
Julieta Abraham-Miranda, Shivanshu Awasthi, Kosj Yamoah
Summary: Health disparities between American men of African and European descent can be attributed to various factors such as socioeconomic status, healthcare access, lifestyle, ancestry, and molecular aberrations. Clinical trials and research studies on prostate cancer are predominantly enrolling European descent men, potentially overlooking existing disparities between races. With advancements in immunotherapies, exploring immunological differences between ethnicities is crucial for developing innovative therapeutic approaches for prostate cancer globally.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Wei Tang, Jay H. Fowke, Lauren M. Hurwitz, Mark Steinwandel, William J. Blot, Stefan Ambs
Summary: The study found that aspirin use was not associated with prostate cancer risk among African-American men in the Southern Community Cohort Study (SCCS), but may be suggestively associated with reduced prostate cancer mortality. Prospective SCCS data suggest that aspirin use may help prevent lethal prostate cancer among this high-risk group of men.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Urology & Nephrology
Molly E. DeWitt-Foy, Kristina Gam, Charles Modlin, Simon P. Kim, Robert Abouassaly
Summary: The study aimed to examine racial disparities in decisional regret among African American men with prostate cancer. Findings revealed that African American men experienced higher levels of decisional regret, partially explained by medical mistrust and concerns about masculinity.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Daniel S. Carlson, Petros Grivas, Wei Wei, Puneet K. Dhillon, Samir Abraksia
Summary: This study aims to compare shared decision making and informed decision making among high-risk African American men in prostate cancer screening, finding that educational tools significantly improved knowledge about prostate cancer screening in both groups.
CANCER INVESTIGATION
(2021)
Article
Primary Health Care
Nicholas Shungu, Katherine R. Sterba
Summary: Black men may lack the prerequisite information to make informed decisions about PrCa screening, which is notable in light of known PrCa racial disparities. Clinicians can facilitate informed decision-making by discussing the benefits and risks of PrCa screening, educating about racial disparities, and engaging in open communication with Black men.
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2021)
Review
Oncology
Kevin H. Kensler, Roman Johnson, Faith Morley, Mohamed Albrair, Barbra A. Dickerman, Roman Gulati, Sarah K. Holt, Hari S. Iyer, Adam S. Kibel, Jenney R. Lee, Mark A. Preston, Jason L. Vassy, Erika M. Wolff, Yaw A. Nyame, Ruth Etzioni, Timothy R. Rebbeck
Summary: Limited evidence from observational and modeling studies suggests that African American men should be screened for prostate cancer. Consideration should be given to initiating screening of African American men at younger ages (eg, 45-50 years) and at more frequent intervals relative to other racial groups in the United States. Screening intervals can be optimized by using a baseline prostate-specific antigen measurement in midlife. Finally, no evidence has indicated that African American men would benefit from screening beyond 75 years of age; in fact, this group may experience higher rates of overdiagnosis at older ages.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Oncology
Pinky Shani, Eli Walter
Summary: Mind-body interventions are well-received among African American cancer survivors and have the potential to improve their quality of life and physical and mental health outcomes. However, there is a lack of research specifically focused on this population, and barriers exist in accessing these interventions within African American communities.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Oncology
Gary Hardiman, Stephen J. Savage, E. Starr Hazard, Willian A. da Silveira, Rebecca Morgan, Adam Harris, Melanie S. Jefferson, Robert C. Wilson, Susan Caulder, Linda Ambrose, Lewis Frey, Bethany Wolf, Sebastiano Gattoni-Celli, Chanita Hughes Halbert
Summary: Men of African origin have a higher likelihood of developing and dying from prostate cancer compared to men of European origin, with specific gene expression differences and clinical characteristics. This study identified a gene expression signature that separates African American men with the most severe clinical features, linking to elevated Gleason scores and vitamin D deficiency. Protein-protein interaction network analysis revealed a high degree of connectivity within genes associated with racial differences.
Article
Geriatrics & Gerontology
Supriya Mohile, Caroline S. Blaum, Peter M. Abadir, William Dale, Daniel E. Forman, Chunkit Fung, Holly M. Holmes, Javid Moslehi, Karen M. Mustian, Michael W. Rich, Heather E. Whitson
Summary: This report summarizes the presentations, discussions, and recommendations of a recent research conference on Cancer and Cardiovascular Disease, organized by the American Geriatrics Society and the National Institute on Aging. The conference aimed to address the relationship between cancer and heart disease, which are the leading causes of death among older Americans. The discussions covered topics such as the mechanisms of co-development of cancer and cardiovascular disease, the cardiotoxic effects of cancer therapy, and the management of comorbid cancer and cardiovascular disease.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Letter
Hematology
Erin Watson, Chandrika Sanapala, Ashley -Marie Cortes, Heidi D. Klepin, Marsha Wittink, Sally Norton, Daniel R. Richardson, William Dale, Allison Magnuson, Jason H. Mendler, Jane Liesveld, Eric Huselton, Kristen O'Dwyer, Thomas W. LeBlanc, Areej El-Jawahri, Melisa L. Wong, Kah Poh Loh
Article
Neurosciences
Bihong T. Chen, Zikuan Chen, Frank Deng, Sunita K. Patel, Mina S. Sedrak, James C. Root, Tim A. Ahles, Marianne Razavi, Heeyoung Kim, Can-Lan Sun, William Dale
Summary: This study aimed to investigate the impact of chemotherapy on brain functional resting-state signal variability and cognitive function in older long-term survivors of breast cancer. The findings revealed a significant decrease in SDBOLD in the CH group, indicating potential alterations in brain function in breast cancer survivors exposed to chemotherapy.
Letter
Medicine, General & Internal
Mina S. Sedrak, Jingran Ji, Abhay Tiwari, Supriya G. Mohile, William Dale, Jennifer G. Le-Rademacher
Article
Neuroimaging
Ebenezer Daniel, Frank Deng, Sunita K. Patel, Mina S. Sedrak, Heeyoung Kim, Marianne Razavi, Can-Lan Sun, James C. Root, Tim A. Ahles, William Dale, Bihong T. Chen
Summary: This study aimed to evaluate alterations in cortical thickness and cognition in older long-term survivors of breast cancer who had been treated with chemotherapy. The results showed that long-term chemotherapy could lead to cortical thinning and cognitive decline in older cancer survivors.
BRAIN IMAGING AND BEHAVIOR
(2023)
Review
Oncology
Laura Ashley, Claire Surr, Rachael Kelley, Mollie Price, Alys Wyn Griffiths, Nicole R. Fowler, Dana E. Giza, Richard D. Neal, Charlene Martin, Jane B. Hopkinson, Anita O'Donovan, William Dale, Bogda Koczwara, Katie Spencer, Lynda Wyld
Summary: With the aging population, cancer patients are getting older and more likely to have preexisting comorbidities, such as dementia. People with dementia are vulnerable to health disparities, which can complicate cancer care and outcomes.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Eva Culakova, Supriya G. Mohile, Luke Peppone, Erika Ramsdale, Mostafa Mohamed, Huiwen Xu, Megan Wells, Rachael Tylock, Jim Java, Kah Poh Loh, Allison Magnuson, Leah Jamieson, Victor Vogel, Paul R. Duberstein, Benjamin P. Chapman, William Dale, Marie Anne Flannery
Summary: Providing a geriatric assessment summary with management recommendations to oncologists reduces clinician-rated toxicity in older patients with advanced cancer receiving treatment. A GA intervention for older patients with advanced cancer reduces patient-reported symptomatic toxicity in the presence of a high baseline symptom burden.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Mina S. Sedrak, Can-Lan Sun, Jingran Ji, Harvey J. Cohen, Cary P. Gross, William P. Tew, Heidi D. Klepin, Tanya M. Wildes, Efrat Dotan, Rachel A. Freedman, Tracey O'Connor, Selina Chow, Mary Ann Fenton, Beverly Moy, Andrew E. Chapman, William Dale, Vani Katheria, Nicole M. Kuderer, Gary H. Lyman, Allison Magnuson, Hyman B. Muss
Summary: Older women with high-risk early breast cancer often suffer from toxic side effects during adjuvant chemotherapy, leading to dose reductions and delays. Identifying women at risk of receiving suboptimal dose intensity may improve treatment discussions and guide early supportive care interventions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marianne Razavi, Cristiane Decat Bergerot, Errol J. Philip, William Dale
Summary: This study investigated the factors influencing adherence to breast and prostate cancer screening intervals in older adults. Age, income, and insurance status were found to have a significant impact on the timing of screenings. Participants aged 60-79, African American women, and physically active men were more likely to undergo screenings earlier. These findings highlight the importance of socioeconomic and lifestyle factors in screening timing.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Oncology
Marissa LoCastro, Chandrika Sanapala, Ying Wang, Marielle Jensen-Battaglia, Marsha Wittink, Sally Norton, Heidi D. Klepin, Daniel R. Richardson, Jason H. Mendler, Jane Liesveld, Eric Huselton, Kristen O'Dwyer, Ashley-Marie Cortes, Chrystina Rodriguez, William Dale, Kah Poh Loh
Summary: This study assessed the feasibility and usefulness of a patient-centered communication tool (UR-GOAL tool) for treatment decision making between older patients with AML, their caregivers, and oncologists. The results showed that the UR-GOAL tool helped patients understand their diagnosis and treatment options, improve communication with oncologists, and make more informed decisions.
Article
Oncology
Cristiane Decat Bergerot, Paulo Gustavo Bergerot, Marianne Razavi, Errol J. Philip, Sabri Lakhdari, Marcos Vinicius da Silva Franca, Lorena Nascimento Manrique Molina, Alici Natalia de Sousa Freitas, Mariane Cunha Taveira, Andressa Cardoso de Azeredo, William Hiromi Fuzita, Cristiano Menezes Fernandes, Raquel Batista Pio, Romildo de Araujo, Milena Macedo Couto, Vitor Fiorin de Vasconcellos, Maria Fernanda Nonino, David Lee, Joao Nunes de Matos Neto, Marco Murilo Buso, Enrique Soto-Perez-de-Celis, William Dale
Summary: This study aimed to determine the feasibility and acceptability of a remote geriatric assessment (GA) and implementation (GAIN) program in Brazil. The program showed high feasibility and acceptability among older adults with cancer receiving treatment, and significant improvement in health-related quality of life (HR-QOL) outcomes was observed. The GAIN program could also guide early detection of chemotherapy toxicity and improve patient-reported outcomes in low-resource environments.
Article
Health Care Sciences & Services
Elizabeth T. Loggers, Amy A. Case, Marcin Chwistek, William Dale, Marvin O. Delgado Guay, Stephen B. Edge, Steven R. Grossman, Jillian Gustin, Judith Nelson, Sahana Rajasekhara, Akhila Reddy, James A. Tulsky, Finly Zachariah, Kristen McNiff Landrum
Summary: The Alliance of Dedicated Cancer Centers (ADCC) initiated the Improving Goal Concordant Care Initiative (IGCC) to address the lack of formal communication training and institutional support among oncologists. IGCC requires four core components for participation, aiming to improve patient outcomes and promote care that aligns with patient preferences.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Oncology
Janet V. Mokhnatkin, Marie Bae, William Dale, Abhay Tiwari, Jasmine Patanapirom, Mina S. Sedrak
Summary: This study examines the perceived facilitators and barriers to cancer trial enrollment from the perspective of older patients with breast cancer and their family caregivers. The findings suggest that while there is agreement on the clinical benefit of trials and physician recommendation, there is divergence in terms of patient motivation and the perceived influence of the caregiver on enrollment.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
William Dale, Heidi D. Klepin, Grant R. Williams, Shabbir M. H. Alibhai, Cristiane Bergerot, Karlynn Brintzenhofeszoc, Judith O. Hopkins, Minaxi P. Jhawer, Vani Katheria, Kah Poh Loh, Lisa M. Lowenstein, June M. Mckoy, Vanita Noronha, Tanyanika Phillips, Ashley E. Rosko, Tracy Ruegg, Melody K. Schiaffino, John F. Simmons, Ishwaria Subbiah, William P. Tew, Tracy L. Webb, Mary Whitehead, Mark R. Somerfield, Supriya G. Mohile
Summary: The purpose of this article is to update the ASCO guideline on the practical assessment and management of age-associated vulnerabilities in older patients undergoing systemic cancer therapy. The panel recommends the use of geriatric assessments to identify vulnerabilities or impairments in older adults with cancer and to guide their care plan. The Practical Geriatric Assessment is one option for this purpose.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Daneng Li, Can-Lan Sun, Heeyoung Kim, Christiana Crook, Ya-Han Zhang, Rebecca Allen, Richard Ballena, Shadman Hyder, Marianna Koczywas, Vincent Chung, Dean Lim, Vani Katheria, William Dale, Gagandeep Singh
Summary: This study investigated treatment goals and health outcome preferences of patients with neuroendocrine tumors (NETs) and found that patients prioritize quality of life and independence over survival. Improved communication between patients and physicians is needed to ensure patient preferences are taken into consideration.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)