Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
Summary: Studies suggest that blood-brain barrier crossing renin-angiotensin drugs may be linked to less memory decline, while nonpenetrant medications may help improve attention.
Article
Medicine, General & Internal
Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney Fletcher, Andrew M. South, Thomas A. Murray, Christopher Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: This study found that oral administration of losartan did not improve the PaO2:FiO(2) ratio at 7 days in hospitalized patients with COVID-19 and acute lung injury. The use of losartan also did not improve secondary clinical outcomes and resulted in fewer vasopressor-free days compared to placebo.
Article
Oncology
Marcin Zeman, Wladyslaw Skalba, Agata Malgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski, Agnieszka Czarniecka
Summary: The use of ARBs instead of ACEIs may improve the outcome of the combined therapy for rectal cancer patients with associated hypertension.
Article
Urology & Nephrology
Maria Jose Soler, Aida Ribera, Josep R. Marsal, Ana Belen Mendez, Mireia Andres, Maria Antonia Azancot, Gerard Oristrell, Leonardo Mendez-Boo, Jordana Cohen, Jose A. Barrabes, Ignacio Ferreira-Gonzalez
Summary: In a cohort study of HTN patients, it was found that the use of ACEi/ARBs reduced the risk of COVID-19 infection without increasing disease severity.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Neurosciences
Bernardo H. M. Correa, Luca Becari, Marco Antonio Peliky Fontes, Ana Cristina Simoes-E-Silva, Lucas M. Kangussu
Summary: This comprehensive review summarizes the current knowledge on the participation of renin-angiotensin system (RAS) components in different adverse environmental stimuli stressors. It explores the effects of the activation of the classical RAS axis and the counter-regulatory axis on stress-related cardiovascular, endocrine, and behavioral responses. Pharmacological modulation in both axes shows promising perspectives for stress-related disorders treatment, with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers being potential candidates.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rohan Khera, Callahan Clark, Yuan Lu, Yinglong Guo, Sheng Ren, Brandon Truax, Erica S. Spatz, Karthik Murugiah, Zhenqiu Lin, Saad B. Omer, Deneen Vojta, Harlan M. Krumholz
Summary: The study found that ACE inhibitors and ARBs were not significantly associated with the risk of COVID-19 hospitalization or mortality. Despite some tendency to lower hospitalization risk in older individuals, recent data consistency supports this conclusion.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jaejin An, Rong Wei, Hui Zhou, Tiffany Q. Luong, Michael K. Gould, Matthew T. Mefford, Teresa N. Harrison, Beth Creekmur, Ming-Sum Lee, John J. Sim, Jeffrey W. Brettler, John P. Martin, Angeline L. Ong-Su, Kristi Reynolds
Summary: The study found that the use of ACEIs or ARBs was not significantly associated with COVID-19 infection among patients with hypertension. However, there was a lower odds of COVID-19 infection among adults over 85 years old using ACEIs, suggesting that further investigation is warranted.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cell Biology
Zheng Ma, Mei-Ping Wang, Lian Liu, Shuang Yu, Tian-Ran Wu, Lei Zhao, Ye-Ping Zhang, Hai-Feng Liang, Xin-Chun Yang
Summary: The meta-analysis suggests that the use of ACEI/ARB may increase the risk of COVID-19 infection in the general population, but not in hypertensive individuals. Additionally, ACEI/ARB usage was not associated with adverse outcomes in COVID-19 patients.
Article
Medicine, General & Internal
Francisco J. de Abajo, Antonio Rodriguez-Miguel, Sara Rodriguez-Martin, Victoria Lerma, Alberto Garcia-Lledo
Summary: The study found that discontinuation of ACEIs/ARBs in COVID-19 patients did not improve in-hospital survival. On the contrary, continued use of ARBs was associated with a trend towards reduced mortality compared to discontinuation, and significantly lower mortality risk compared to continued use of ACEIs, especially in high-risk patients.
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Driss Laghlam, Anis Chaba, Matthias Tarneaud, Julien Charpentier, Jean-Paul Mira, Frederic Pene, Clara Vigneron
Summary: This retrospective study aimed to assess the prognostic impact of renin-angiotensin system blockers (RABs) in critically ill cancer patients. The results showed that the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEis) was associated with improved in-ICU survival and one-year survival. Cellular evidence supports the beneficial impact of RABs on the survival rates of solid tumor patients.
Article
Health Policy & Services
Judy R. Dubno, Pranab Majumder, Janet Prvu Bettger, Rowena J. Dolor, Victoria Eifert, Howard W. Francis, Carl F. Pieper, Kristine A. Schulz, Mina Silberberg, Sherri L. Smith, Amy R. Walker, David L. Witsell, Debara L. Tucci
Summary: This study conducted a cost-effectiveness analysis of hearing screening in primary care clinics, finding that completing the screening during a clinic visit had the highest average cost per patient, but the lowest average cost per patient who failed the screening. Providing hearing screening to older adults during their primary care visit is cost-effective and improves quality of life.
COST EFFECTIVENESS AND RESOURCE ALLOCATION
(2022)
Article
Medicine, General & Internal
Matthew W. McCarthy, Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart, G. Michael Felker, Dushyantha Jayaweera, Mark Sulkowski, Nina Gentile, Carolyn Bramante, Upinder Singh, Rowena J. Dolor, Juan Ruiz-Unger, Sybil Wilson, Allison DeLong, April Remaly, Rhonda Wilder, Sean Collins, Sarah E. Dunsmore, Stacey J. Adam, Florence Thicklin, George Hanna, Adit A. Ginde, Mario Castro, Kathleen McTigue, Elizabeth Shenkman, Adrian F. Hernandez
Summary: This study aimed to evaluate the efficacy of low-dose fluvoxamine (50 mg twice daily for 10 days) compared with placebo for the treatment of mild to moderate COVID-19. The results showed that treatment with fluvoxamine did not improve the time to sustained recovery compared with placebo. These findings do not support the use of fluvoxamine at this dose and duration in patients with mild to moderate COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Alexandra F. Dalton, Carol E. Golin, Carolyn Morris, Christine E. Kistler, Rowena J. Dolor, Kaitlyn B. Bertin, Krithika Suresh, Swati G. Patel, Carmen L. Lewis
Summary: This secondary analysis aimed to investigate the impact of a targeted patient decision aid on the screening preferences of older adults for colorectal cancer (CRC) screening. The results of the study showed no significant differences in patient preferences between the intervention and control groups in different health states.
Article
Nutrition & Dietetics
Ranee Chatterjee, Clemontina A. Davenport, Ellen M. Vickery, Karen C. Johnson, Sangeeta R. Kashyap, Erin S. LeBlanc, Jason Nelson, Samuel Dagogo-Jack, Anastassios G. Pittas, Bess Dawson Hughes
Summary: Higher serum 25-hydroxyvitamin D is associated with lower type 2 diabetes risk. The effect of vitamin D on diabetes differs among people of color and those with overweight/obesity compared with individuals who are White or have normal weight.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Tracy Y. Wang, Abdus S. Wahed, Alison Morris, Lisa Baumann Kreuziger, John G. Quigley, Gervasio A. Lamas, Alexandra J. Weissman, Jose Lopez-Sendon, M. Margaret Knudson, Deborah M. Siegal, Raj S. Kasthuri, Andrew J. Alexander, Lana Wahid, Bassel Atassi, Peter J. Miller, Janice W. Lawson, Bela Patel, Jerry A. Krishnan, Nancy L. Shapiro, Deborah E. Martin, Andrei L. Kindzelski, Eric S. Leifer, Jungnam Joo, Lingyun Lyu, Annie Pennella, Brendan M. Everett, Mark W. Geraci, Kevin J. Anstrom, Thomas L. Ortel
Summary: This study aimed to determine whether anticoagulation is effective in reducing death and thromboembolic complications among patients discharged after COVID-19 hospitalization. The study was terminated early due to a lower-than-expected event rate and declining COVID-19 hospitalizations, leading to inconclusive results.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fernando J. Martinez, MeiLan K. Han, Camden Lopez, Susan Murray, David Mannino, Stacey Anderson, Randall Brown, Rowena Dolor, Nancy Elder, Min Joo, Irfan Khan, Lyndee M. Knox, Catherine Meldrum, Elizabeth Peters, Cathie Spino, Hazel Tapp, Byron Thomashow, Linda Zittleman, Barry Make, Barbara P. Yawn
Summary: Chronic obstructive pulmonary disease (COPD) is often undiagnosed in primary care. The CAPTURE screening tool is effective in identifying US primary care patients with clinically significant, undiagnosed COPD.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Jessica E. Ma, Jared Lowe, Callie Berkowitz, Azalea Kim, Ira Togo, R. Clayton Musser, Jonathan Fischer, Kevin Shah, Salam Ibrahim, Hayden B. Bosworth, Annette M. Totten, Rowena Dolor
Summary: This study aimed to describe the implementation and usage of an EHR notification for referring patients to an ACP study, evaluate the association of notifications with study referrals and engagement in ACP, and assess provider interactions with and perspectives on the notifications. It was found that an EHR notification can be effective in reminding providers to perform ACP conversations and refer patients to a clinical study, but excessive notifications may lead to alert fatigue and diminishing returns.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Geriatrics & Gerontology
Jacob M. Joseph, Nicholas J. Pajewski, Rowena Dolor, Mary Ann H. Sellers, Letitia R. Perdue, Sheronda M. Peeples, Adam Henrie, Nancy Woolard, W. Schuyler P. Jones, Catherine R. Benziger, Ariela S. Orkaby, Amanda J. Mixon, Jeffrey D. VanWormer, Michael E. Shapiro, Christine S. Kistler, Tamar Polonsky, Ranee M. Chatterjee, Alanna E. Chamberlain, Daniel U. Forman, Kirk M. Knowlton, Thomas Gill, L. Kristin G. Newby, Bradley S. Hammill, Mine A. Cicek, Neely E. Williams, Jake Decker, Jiafu Ou, Jack Rubinstein, Gaurav Choudhary, Raul J. E. Gazmuri, Kenneth L. Schmader, Christianne P. Roumie, Camille B. Vaughan, Mark M. Effron, Rhonda A. Cooper-DeHoff, Mark C. Supiano, Raj C. Shah, Jeffrey F. Whittle, Adrian T. Hernandez, Walter D. Ambrosius, Jeff P. Williamson, Karen Alexander
Summary: This is a clinical trial that aims to investigate whether the initiation of statins can improve survival free of dementia and disability in adults aged 75 years and older. The trial will compare the effects of high-intensity statin therapy with placebo in a large population. The results will provide important insights into the impact of statins on the survival of older adults with dementia and disability.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Multidisciplinary Sciences
Mounira Ozoor, Mark Gritz, Rowena J. Dolor, Jodi Summers Holtrop, Zhehui Luo
Summary: This cohort study analyzed the patterns of uptake of Intensive Behavioral Therapy (IBT) for obesity services among primary care providers (PCPs) serving the Medicare population in the U.S. Results showed that only a small percentage of PCPs continuously provided IBT services for Medicare patients with obesity, highlighting the need for further investigation and interventions.
Correction
Medicine, Research & Experimental
Tara G. G. Mehta, Jane Mahoney, Aaron L. L. Leppin, Kathleen R. R. Stevens, Reza Yousefi-Nooraie, Brad H. H. Pollock, Rachel C. C. Shelton, Rowena Dolor, Harold Pincus, Sapana Patel, Justin B. Moore
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Anesthesiology
Marian Wilson, Rowena J. Dolor, Daniel Lewis, Saundra L. Regan, Mary Beth Vonder Meulen, T. John Winhusen
Summary: Nonpharmacological interventions, such as online pain self-management programs, can effectively reduce opioid dose and manage pain for adults on long-term opioid therapy. These programs have significant benefits in reducing morphine equivalent dose and improving pain outcomes.
Meeting Abstract
Health Care Sciences & Services
Jessica Ma, Jared Lowe, Callie Berkowitz, Azalea Kim, Ira Togo, R. Clayton Musser, Jonathan Fischer, Kevin Shah, Annette Totten, Rowena Dolor
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Meeting Abstract
Health Care Sciences & Services
Anupama Gangavati, Maren Olsen, Deborah Ejem, Ramona Rhodes, Rowena Dolor, Raegan Durant, DeAndra Bodiford, Nadine Barrett, Sherone Williams, Gabriel Thorne, Kenisha Bethea, Kimberly Johnson, Felicia Ruffin
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Meeting Abstract
Health Care Sciences & Services
Seiko Izumi, Chrystal Barnes, Jeanette Daly, Megan Schmidt, Shelbey Hagen, Kylie Lanman, Taryn Bogdewiecz, Jessica Ma, Rowena Dolor
IMPLEMENTATION SCIENCE
(2022)
Correction
Medicine, Research & Experimental
Rachel C. Shelton, Rowena J. Dolor, Jonathan N. Tobin, Ana Baumann, Catherine Rohweder, Sapana Patel, Laura-Mae Baldwin
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)