Article
Clinical Neurology
Claire Lefeuvre, Marie De Antonio, Francoise Bouhour, Celine Tard, Emmanuelle Salort-Campana, Emmeline Lagrange, Anthony Behin, Guilhem Sole, Jean-Baptiste Noury, Sabrina Sacconi, Armelle Magot, Aleksandra Nadaj-Pakleza, Arnaud Lacour, Stephane Beltran, Marco Spinazzi, Pascal Cintas, Dimitri Renard, Maud Michaud, Anne-Laure Bedat-Millet, Helene Prigent, Nadjib Taouagh, Azzeddine Arrassi, Dalil Hamroun, Shahram Attarian, Pascal Laforet, Pompe Study Grp
Summary: This study provides an update on the clinical and biological features of patients with late-onset Pompe disease in the French registry. The findings suggest that the disease is now diagnosed earlier and with lower clinical severity. The 6-minute walk test remains an important method for assessing motor performance and walking ability. The French registry provides a comprehensive overview of Pompe disease in the country and can be used to evaluate responses to future treatments.
Article
Psychiatry
Ping Rong, Shuyi Zhao, Qianfang Fu, Mengrui Chen, Libin Yang, Yifei Song, Xilian Zhang, Rong Ma
Summary: This article discusses a 5-year-old girl with autism spectrum disorder (ASD) whose serum creatine kinase and creatine kinase MB isoenzyme levels have been rising for nearly 2 years. After treatment with traditional Chinese medicine, the creatine kinase MB isoenzyme level decreased dramatically. This indicates that patients with ASD may experience long-term increases in serum creatine kinase levels, and traditional Chinese medicine can temporarily reduce the creatine kinase MB isoenzyme level.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Julius Jarvilehto, Sandra Harjuhaahto, Edouard Palu, Mari Auranen, Jouni Kvist, Henrik Zetterberg, Johanna Koskivuori, Marko Lehtonen, Anna Maija Saukkonen, Manu Jokela, Emil Ylikallio, Henna Tyynismaa
Summary: This study investigated serum biomarkers in patients with mitochondrial CHCHD10-linked spinal muscular atrophy Jokela (SMAJ) type. The study found alterations in NfL and GFAP levels in serum, as well as increased creatine kinase and changes in several metabolites. These findings suggest a metabolic shift and indicate the involvement of skeletal muscle in disease pathogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Lei Wang, Yanan Lu, Yujing Yang, Hanli Li, Yu Wang
Summary: This study found that 31.7% of patients experienced elevated creatine kinase after seizures, and fever and elevated leukocyte count were identified as independent risk factors for seizure-related hyperCKemia.
Article
Neurosciences
Enrico Adriano, Annalisa Salis, Gianluca Damonte, Enrico Millo, Maurizio Balestrino
Summary: The study suggests that acute administration of GAA does not have epileptogenic or neurotoxic effects on the brain. Additionally, diacetyl-GAAE improves tissue viability but not through an increase in creatine or phosphocreatine.
Article
Clinical Neurology
Pannathat Soontrapa, Shelly Shahar, Lattawat Eauchai, Floranne C. Ernste, Teerin Liewluck
Summary: Isolated aldolase elevation can be found in a greater variety of myopathies than initially thought and most were treatable. Dermatomyositis is the most common myopathy with selective elevation of aldolase in our cohort, which features some unique characteristics compared to dermatomyositis with hyperCKemia.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Poggio, Martina Brofiga, Mariateresa Tedesco, Paolo Massobrio, Enrico Adriano, Maurizio Balestrino
Summary: In this study, the acute and chronic effects of GAA on the electrophysiology of cultured neurons were investigated using MEAs. The results showed that GAA at normal cerebrospinal fluid concentration did not affect any of the parameters tested, while at GAMT deficiency concentration, it only affected the bursting rate of neocortical networks and the burst duration of hippocampal networks. At the highest concentration, it caused a decrease in all parameters. These findings indicate that GAA is not epileptogenic.
Article
Endocrinology & Metabolism
Bing Kang, Chuan Peng, Kanran Wang, Ying Song, Yi Yang, Linqiang Ma, Mei Mei, Jinbo Hu, Shumin Yang, Fei-Fei Wu, Qifu Li
Summary: The study found that the serum levels of myoglobin were significantly increased in patients with primary aldosteronism, and myoglobin was independently correlated with plasma aldosterone concentration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ze Chen, Thea Laurentius, Yvonne Fait, Aline Mueller, Eva Mueckter, Leo Cornelius Bollheimer, Mahtab Nourbakhsh
Summary: Sarcopenia, characterized by muscle loss, can be diagnosed by measuring appendicular skeletal muscle index (ASMI). A study on older adults found positive correlations between ASMI and nutritional status (p = 0.001) and serum creatine kinase (CK) (p = 0.019), but negative correlations with serum CXCL12a (p = 0.023) and interleukin (IL)-7 (p = 0.024). The study identified advanced age, malnutrition, low CK levels, and high CXCL12a levels as risk factors for sarcopenia. Combining low CK and high CXCL12a levels can be used as serum markers for sarcopenia. The linear correlation between ASMI and CXCL12a levels may aid future studies on sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Vitor Bruno Bianconi Rosa, Ivan Felismino Charas dos Santos, Leticia Gondim Souto, Emilia de Paiva Porto, Dietrich Pizzigatti, Bruno Fornitano Cholfe, Breno Fernando Martins de Almeida, Thais Helena Constantino Patelli, Regina Kiomi Takahira
Summary: This study aimed to evaluate the effects of acupuncture on rodeo bulls in training by measuring hematological variables, CK, AST, fibrinogen, and plasma lactate levels. The results showed that bulls treated with acupuncture had smaller variations in hemogram, increased eosinophils levels, and lower plasma lactate levels after exercise compared to the control group. The findings suggest that acupuncture treatment can have positive effects on the physiological response to exercise in rodeo bulls.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Saria Dbar, Olga Akhmadullina, Elena Sabelnikova, Nikolai Belostotskiy, Asfold Parfenov, Svetlana Bykova, Sergey Bakharev, Elena Baulo, Alexandra Babanova, Lilia Indeykina, Tatyana Kuzmina, Tatiana Kosacheva, Aleksey Spasenov, Alina Makarova
Summary: This study found that in 78 out of 82 patients with FBD, gastrointestinal symptoms were associated with disaccharidase deficiency.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Rheumatology
Suparaporn Wangkaew, Jirapath Intum, Narawudt Prasertwittayakij, Juntima Euathrongchit
Summary: This study found that elevated baseline serum CK in early SSc, with the majority being DcSSc subtype, is associated with more severe clinical presentation, higher incidence of cardiopulmonary complications, and shorter survival time compared with the non-elevated CK subgroup.
CLINICAL RHEUMATOLOGY
(2022)
Article
Emergency Medicine
Jie Yang, Xuelian Liao, Wanhong Yin, Bo Wang, Jirong Yue, Lang Bai, Dan Liu, Ting Zhu, Zhixin Huang, Yan Kang
Summary: In patients with COVID-19, elevated levels of CK-MB and myoglobin on admission may serve as effective predictors for adverse outcomes, with a better performance observed when using them in combination.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Hongjiao Gao, Qiao Xiang, Jindie Li, Meng Yu, Yalin Lan, Junqiang Ba, Yan Liu, Haoming Tian
Summary: Patients with Sheehan's syndrome are prone to elevated serum muscle enzymes, which may be associated with hypothyroidism and hyponatremia. Routine monitoring of serum muscle enzymes is important for patient management.
Article
Critical Care Medicine
Virginie Tarazona, Samy Figueiredo, Sophie Hamada, Jonas Pochard, Ryan W. Haines, John R. Prowle, Jacques Duranteau, Bernard Vigue, Anatole Harrois
Summary: This study demonstrates that in trauma patients, admission myoglobin performs better than CK in predicting AKI, and myoglobin adds predictive value to established models of AKI prediction.
ANNALS OF INTENSIVE CARE
(2021)