Article
Biochemistry & Molecular Biology
Sanaz Gharaei, Mandana Ohadi, Mehdi Hassanshahian, Sara Porsheikhali, Hamid Forootanfar
Summary: This study isolated a potential glycolipid biosurfactant resource, S. algae, from marine samples in the Persian Gulf and optimized its production through a two-level factorial design. The glycolipid biosurfactant exhibited functional properties such as reducing water surface tension, degrading alkanes, and inhibiting pathogenic bacteria.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
William Gustavo Lima, Francisco Leandro Batista Filho, Iasmin Pinheiro Lima, Daniela Carolina Simiao, Julio Cesar Moreira Brito, Waleska Stephanie da Cruz Nizer, Valbert Nascimento Cardoso, Simone Odilia Antunes Fernandes
Summary: In this study, we demonstrated that melittin, derived from honeybee venom, has in vitro and in vivo antibacterial and anti-biofilm activities against uropathogenic Escherichia coli resistant to quinolones. Melittin showed rapid and potent bactericidal effect against a quinolone-resistant and ESBL-producing UPEC strain, and it was able to decrease the minimum inhibitory concentration of ceftizoxime by forming pores in the membrane. Furthermore, melittin disrupted mature biofilms and inhibited the adhesion of UPEC to urethral catheter surfaces.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Caterina D'Angelo, Angela Casillo, Chiara Melchiorre, Concetta Lauro, Maria Michela Corsaro, Andrea Carpentieri, Maria Luisa Tutino, Ermenegilda Parrilli
Summary: The need for new approaches to prevent microbial surface adhesion and biofilm formation is increasing due to the impact of biofilm-related infections on human health. This study focused on an Antarctic marine bacterium called Psychrobacter sp. TAE2020, which produces a protein-polysaccharide complex named CATASAN that can inhibit the attachment and formation of Staphylococcus epidermidis biofilms. CATASAN is also emulsifying and can be used in various biotechnological applications.
Article
Biotechnology & Applied Microbiology
Qiuxia Fan, Yahong Yuan, Hang Jia, Xuejun Zeng, Zhouli Wang, Zhongqiu Hu, Zhenpeng Gao, Tianli Yue
Summary: The study showed that thymoquinone has antimicrobial and anti-biofilm activities against Shigella flexneri by disrupting cell morphology, inhibiting protein synthesis, and downregulating genes involved in biofilm formation. Thymoquinone has the potential to be used as a natural agent to combat contamination and infection caused by Shigella flexneri.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Juanjuan Xu, Yuanpei Li, Haojie Wang, Mengxi Zhu, Wenpo Feng, Gaofeng Liang
Summary: The study successfully developed an AMP@PDA@AgNPs nanocomposite with excellent biocompatibility and strong antimicrobial activity, capable of disrupting bacterial biofilms. The nanocomposite showed potential in treating bacterial infections by inhibiting the expression of biofilm-related genes. The synergistic strategy of AMPs and AgNPs provided a new perspective for the treatment of bacterial infections.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Y. Wang, J. Chen, X. Liu
Summary: This review discusses the inhibitory effects of Sophorolipids (SLs) on bacterial and fungal growth and their biofilm formation, as well as the synergistic effects of SLs combined with other antimicrobial substances. The antimicrobial mechanisms of SLs action and future research directions for the development of SLs as antimicrobial therapeutics are also explored.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Maryam Mansouri, Nazanin Khayam, Elham Jamshidifar, Tara Pourseif, Sepideh Kianian, Amir Mirzaie, Iman Akbarzadeh, Qun Ren
Summary: Niosomes containing streptomycin sulfate were prepared and optimized based on size, polydispersity index, and encapsulation efficiency. The optimized formulation showed a minimum size, low PDI, and maximum EE% values. The drug release investigation indicated a gradual release of streptomycin sulfate from the niosomes over time, with higher antimicrobial activities against bacteria and minimal cytotoxicity against human cell lines.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Agriculture, Multidisciplinary
Renato Dias Matosinhos, Karina Cesca, Bruno Augusto Mattar Carciofi, Debora de Oliveira, Cristiano Jose de Andrade
Summary: This article critically discusses the current status and future trends of mannosylerythritol lipids as green pesticides and biostimulants for seed germination and plant growth. It highlights their potential to partially replace synthetic pesticides, stimulate plant growth, and reduce phytopathogen infections.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Meta Sternisa, Jerica Sabotic, Anja Klancnik
Summary: This study presents the use of growth curves of Salmonella Infantis to determine antimicrobial and anti-biofilm activities simultaneously, and identifies several potential extracts with anti-Salmonella activities.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nazanin Amirinejad, Poorandokht Shahriary, Mehdi Hassanshahian
Summary: In order to address antibiotic resistance and multidrug-resistant strains, combining biosurfactants with antibiotics has been proposed as an approach to enhance their efficacy. This study examined the antimicrobial activity of biosurfactant produced by Shewanella algae strain B12 against resistant Gram-negative and Gram-positive bacteria. The biosurfactant showed increased antimicrobial activity when combined with antibiotics, except for Amikacin. Additionally, the biosurfactant-antibiotic mixture exhibited synergistic effects against Methicillin-Resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. It also effectively inhibited the formation of biofilms. These findings suggest that biosurfactant-antibiotic mixtures could be potential replacements for traditional antibiotics.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Prateeksha Prateeksha, Rajesh Bajpai, Chandana Rao, Dalip K. Upreti, Saroj K. Barik, Brahma N. Singh
Summary: The research suggests that using AgNPs decorated with anti-QS chrysophanol can effectively inhibit bacterial adhesion and biofouling, reduce the toxicity of AgNPs to cells, exhibit significant biocompatibility, and successfully prevent UC-associated urinary tract infections.
ACS APPLIED NANO MATERIALS
(2021)
Article
Environmental Sciences
Junyuan Guo, Qifan Gao
Summary: The study showed that using a biosurfactant can significantly enhance ethylbenzene removal in a biotrickling filter, with the optimal concentration being 0.1 CMC. Factors such as inlet ethylbenzene concentration and EBRT also affect the removal rate. The biosurfactant changes EPS content and decreases the biofilm's negative surface charge, improving ethylbenzene mass transfer and microbe aggregation for better removal efficiency.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Chemistry, Multidisciplinary
Maria Teresa Rocchetti, Pasquale Russo, Giuseppe Spano, Letizia De Santis, Ilenia Iarusso, Nicola De Simone, Samira Brahimi, Daniela Fiocco, Vittorio Capozzi
Summary: This study reversed the traditional approach for probiotic screening by evaluating the in vitro probiotic properties of microbes already commercialized in the dairy sector. The analyzed strains showed good survival under stressful conditions, strong inhibitory activity against harmful bacteria, high adhesion rates, and anti-inflammatory effects.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Maria Nowacka, Anna Kowalewska, Anna Rygala, Dorota Kregiel, Witold Kaczorowski
Summary: Hybrid polysiloxanes and polysilsesquioxanes grafted with naturally occurring bioactive phytochemicals, eugenol and linalool, were synthesized and their structure and properties were investigated. The antibiofilm activities of the materials were assessed on glass plates coated with different types and contents of active groups using luminometry and fluorescence microscopy. The specific properties of the hybrid coatings, such as chemical structure, surface free energy, and adhesiveness, were correlated with bioactivity. The functionalized polysilsesquioxanes showed the most favorable anti-adhesive effects.