Article
Oncology
I. L. Defize, S. van der Horst, M. Bulbul, N. Haj Mohammad, S. Mook, G. J. Meijer, L. A. A. Brosens, J. P. Ruurda, R. van Hillegersberg
Summary: In patients with cT4b esophageal cancer treated with dCRT followed by a salvage RAMIE, a radical resection rate of 92% was achieved, with acceptable complications and promising survival rates. These results demonstrate the feasibility of a curative surgical treatment for patients with initially irresectable esophageal cancer but underscore the importance of proper preoperative patient selection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Wayne L. Hofstetter
Summary: Variability in the definition of salvage esophagectomy can influence the interpretation of outcomes between trimodality therapy and bimodality therapy. Future studies should consistently define treatment groups.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Jie Pan, Zhichao Liu, Yang Yang, Bin Li, Rong Hua, Xufeng Guo, Yifeng Sun, Chunguang Li, Zhigang Li
Summary: This study compared the safety and efficacy of salvage esophagectomy after definitive chemoradiotherapy (DCRE) with planned esophagectomy after neoadjuvant chemoradiotherapy (NCRE) in patients with esophageal squamous cell carcinoma (ESCC). The results showed that DCRE and NCRE had comparable postoperative complications and prognosis.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Multidisciplinary Sciences
Yu-Xiang Sun, Tian-Yu Zhu, Guo-Jun Wang, Bu-Lang Gao, Rui-Xin Li, Jing-Tao Wang
Summary: The feasibility of using the mesangium or membrane anatomy theory to guide thoracolaparoscopic radical esophagectomy for esophageal cancer was explored. The mesoesophageal group showed significant advantages in terms of surgical duration, blood loss, lymph node harvest, complications, and postoperative recovery.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristen E. Rhodin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, Thomas A. D'Amico
Summary: This study examined the patterns of use of induction therapy for patients with cT2N0M0 esophageal cancer, revealing differences in patient characteristics between those receiving induction therapy and upfront surgery, without any survival benefit associated with induction therapy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Deven C. Patel, Chi-Fu Jeffrey Yang, Douglas Z. Liou, Mark F. Berry
Summary: This study evaluated the treatment and outcomes of proximal esophageal SCC, and found that chemoradiation is the preferred therapy. Surgery did not significantly improve survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Dashan Ai, Jinjun Ye, Shihong Wei, Yunhai Li, Hui Luo, Jianzhong Cao, Zhengfei Zhu, Weixin Zhao, Qin Lin, Huanjun Yang, Xiangpeng Zheng, Jialiang Zhou, Guang Huang, Ling Li, Jiancheng Li, Zhi Zhang, Guoren Zhou, Dayong Gu, Mingyu Du, Miao Mo, HuiXun Jia, Zhen Zhang, Kuaile Zhao
Summary: This randomized clinical trial compared the efficacy and adverse events of fluorouracil, cisplatin, and carboplatin in definitive chemoradiotherapy for patients with esophageal squamous cell carcinoma (ESCC). The results showed that paclitaxel plus fluorouracil did not have superior overall survival compared to paclitaxel plus cisplatin or paclitaxel plus carboplatin regimens in locally advanced ESCC. The cisplatin group had higher rates of hematologic and gastrointestinal toxic effects.
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Multidisciplinary Sciences
Yi-Lin Chang, Ya-Fu Cheng, Hui-Shan Chen, Siao-Chi Wu, Wei-Heng Hung, Heng-Chung Chen, Chang-Lun Huang, Ching-Yuan Cheng, Bing-Yen Wang
Summary: This study compared the survival rates of definitive chemoradiotherapy and esophagectomy with adjuvant chemoradiotherapy in patients with cT1-3/N0-3 esophageal squamous cell carcinoma. The study found that esophagectomy with adjuvant chemoradiotherapy provided better survival outcomes for patients with clinical stage II/III disease compared to definitive chemoradiotherapy, while there was no significant survival difference between the two treatments for patients with clinical stage I disease.
Review
Oncology
Keouna Pather, Erin M. Mobley, Christina Guerrier, Rhemar Esma, Heather Kendall, Ziad T. Awad
Summary: The objective of this study was to determine the long-term survival outcomes and factors associated with overall survival in esophageal cancer patients undergoing a minimally invasive Ivor Lewis esophagectomy. The results showed that MILE offers favorable long-term overall and disease-free survival outcomes, and age, Karnofsky performance status score, stage IV disease, and disease recurrence were identified as prognostic factors for overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Marianne C. Kalff, Laura F. C. Fransen, Eline M. de Groot, Suzanne S. Gisbertz, Grard A. P. Nieuwenhuijzen, Jelle P. Ruurda, Rob H. A. Verhoeven, Misha D. P. Luyer, Richard van Hillegersberg, Mark I. van Berge Henegouwen
Summary: This study compared long-term survival between minimally invasive esophagectomy (MIE) and open surgery (OE) for esophageal cancer. The results showed that the long-term survival rates were similar for MIE and OE in patients undergoing transthoracic or transhiatal procedures. MIE resulted in a more extensive lymphadenectomy, but transhiatal MIE had more postoperative complications.
Article
Multidisciplinary Sciences
Julia K. Grass, Natalie Kusters, Marius Kemper, Jan Tintrup, Felix Piecha, Jakob R. Izbicki, Daniel Perez, Nathaniel Melling, Maximilian Bockhorn, Matthias Reeh
Summary: This study indicates that patients with concomitant liver cirrhosis undergoing curative esophagectomy for malignant disease have worse perioperative outcomes, including higher mortality, anastomotic leakage rate, and sepsis occurrence. Common cirrhosis scores failed to accurately predict the prognosis of these patients, while bilirubin and INR may serve as better prognostic indicators for perioperative outcomes.
Article
Cardiac & Cardiovascular Systems
Uma M. Sachdeva, Andrea L. Axtell, Tiuri E. Kroese, David C. Chang, Christopher R. Morse
Summary: This study found that patients with higher body mass index were more likely to undergo open surgery rather than minimally invasive surgery, with longer operative times. Obese patients were less likely to receive neoadjuvant therapy, and overweight and obese patients had lower rates of receiving preoperative radiation therapy.
ANNALS OF THORACIC SURGERY
(2021)
Review
Oncology
Thomas Bardol, Lorenzo Ferre, Safa Aouinti, Marie Dupuy, Eric Assenat, Jean-Michel Fabre, Marie-Christine Picot, Regis Souche
Summary: This systematic review assesses the survival outcome of surgically treated metastatic esophageal cancer patients and finds that multimodality treatment, including surgery in curative intent, is associated with a significant improvement in three-year overall survival.
Article
Surgery
Torben Glatz, Birte Kulemann, Jasmina Kuvendjiska, Stefan Fichtner-Feigl, Jens Hoeppner
ANZ JOURNAL OF SURGERY
(2020)
Article
Oncology
Jasmina Kuvendjiska, Martha B. Pitman, Verena Martini, Clara Braun, Kim Grebe, Sylvia Timme, Stefan Fichtner-Feigl, Torben Glatz, Claudia Schmoor, Jessica Guenzle, Jens Hoeppner, Birte Kulemann
ANTICANCER RESEARCH
(2020)
Article
Surgery
Jens Hoeppner, Patrick Sven Plum, Heinz Buhr, Ines Gockel, Dietmar Lorenz, Michael Ghadimi, Christiane Bruns
Summary: Based on consensus by DGAV, recommendations suggest increasing the minimum quantity threshold for esophageal cancer surgeries in Germany to improve quality. Prehabilitation programs can enhance patient outcomes, and treatment options for esophageal cancer vary based on stage.
Article
Medicine, General & Internal
Torben Glatz, Rasmus Verst, Jasmina Kuvendjiska, Peter Bronsert, Heiko Becker, Jens Hoeppner, Birte Kulemann
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aina Venkatasamy, Jens Hoeppner, Claus Hellerbrand, Stefan Fichtner-Feigl, Sven A. Lang
Summary: This study demonstrates the significant reduction in migration, invasion, and proliferation of melanoma cells upon specific inhibition of mTORC2 using the novel inhibitor JR-AB2-011, leading to cell death through non-apoptotic pathways. In a syngeneic murine metastasis model, therapy with JR-AB2-011 showed a remarkable decrease in liver metastasis, highlighting the potential of pharmacological blockade of mTORC2 as a novel anti-cancer approach for melanoma liver metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Mira Runkel, Rasmus Verst, Julia Spiegelberg, Stefan Fichtner-Feigl, Jens Hoeppner, Torben Glatz
Summary: Surgery following FLOT chemotherapy for oligometastatic EGAC may improve survival rates, but overall survival remains low for these patients despite complete resection of all tumor manifestations. Patients with a complete histologic response of metastatic lesions to FLOT treatment show significantly higher 5-year survival rates.
Review
Oncology
Julian Hipp, Blin Nagavci, Claudia Schmoor, Joerg Meerpohl, Jens Hoeppner, Christine Schmucker
Summary: A substantial fraction of esophageal cancer patients exhibit post-neoadjuvant pathological complete response. However, there is a lack of thoroughly planned RCTs to provide these patients with optimal treatment.
Editorial Material
Oncology
Jens Hoeppner, Peter Bronsert
Editorial Material
Oncology
Jens Hoeppner
Article
Oncology
Niklas Gebauer, Maria Ziehm, Judith Gebauer, Armin Riecke, Sebastian Meyhoefer, Birte Kulemann, Nikolas von Bubnoff, Konrad Steinestel, Arthur Bauer, Hanno M. Witte
Summary: This study compares several established risk scores and ratios in neuroendocrine neoplasms of the gastro-entero-pancreatic (GEP-NEN) system to evaluate their prognostic capabilities. The Glasgow Prognostic Score (GPS) was found to be the only independent predictor of survival across all stages of GEP-NEN, supporting its clinical utility for risk stratification in this group of patients.
Article
Oncology
Markus Kist, Michael Thomaschewski, Yannick Keck, Thaer S. A. Abdalla, Sylke Ruth Zeissig, Kees Kleihues-van Tol, Ulrich Friedrich Wellner, Tobias Keck, Jens Hoeppner, Richard Hummel
Summary: The incidence of early-onset gastric cancer, defined as gastric cancer occurring in young patients, is relatively low. However, this study found that these young patients with gastric cancer have more aggressive tumors and receive less curative treatment compared to elderly patients. Despite these differences, the survival rate of early-onset gastric cancer patients was significantly better, and age was identified as an independent predictor for better survival.
Article
Oncology
Kirsten Lindner, Daniel Binte, Jens Hoeppner, Ulrich F. Wellner, Dominik M. Schulte, Sebastian M. Schmid, Kim Luley, Inga Buchmann, Lars Tharun, Tobias Keck, Judith Gebauer, Birte Kulemann
Summary: Surgical resection for non-functional pNEN at an ENETS center in Germany showed good clinical and oncological outcomes, with low in-hospital mortality and recurrence rates. Complications and severity did not appear to impact tumor relapse behavior, suggesting the need for future studies to evaluate optimal resection strategies for G2 pNEN.
Review
Medicine, General & Internal
Christine Schmucker, Blin Nagavci, Julian Hipp, Claudia Schmoor, Joerg Meerpohl, Jens Hoeppner
Summary: This scoping review aims to explore the necessity of surgery in patients with postneoadjuvant complete response of oesophageal cancer by summarizing existing research to inform the design and methodology of a prospective multicentre randomised controlled trial. The study will involve searching databases, checking references, and summarizing data to support the planning of a randomised trial in this patient population.
Article
Oncology
Eva Kocsmar, Gabor Lotz, Andras Kiss, Markus Hoerner, Ekaterina Petrova, Nikolaus Freudenberg, Agnes Csanadi, Birte Kulemann, Martin Werner, Peter Bronsert, Ulrich Friedrich Wellner