Article
Biophysics
Colleen A. Roosa, Ismaeel Muhamed, Ashlyn T. Young, Kimberly Nellenbach, Michael A. Daniele, Frances S. Ligler, Ashley C. Brown
Summary: A new high throughput method for generating fibrin nanoparticles using probe sonication was reported in this study, which can promote clot formation and cell migration. When combined with fibrinogen, sonicated fibrin nanoparticles can form a fibrin gel and support cell migration, which is relevant for wound healing. The results suggest that sonicated fibrin nanoparticles may be a promising therapy for wound healing that is easy to produce and deliver in a flowable formulation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Immunology
Luciana P. F. Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B. de C. O. Lima, Gabriela R. Haddad, Marcia A. N. Gatti, Natalia Bronzatto Medolago, Marcia Tonin Rigotto Carneiro, Lucilene Delazari dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Summary: The study evaluated the safety and efficacy of HFS in treating chronic venous ulcers, showing promising results in healing ulcers. However, further multicentric phase III clinical trials are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Takahiro Yanagihara, Naoki Maki, Tomoyuki Kawamura, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Shiharu Watanabe, Tetsushi Taguchi, Yukio Sato
Summary: This study investigated the long-term efficacy and safety of ApGltn sealant using rats as a preclinical model. The results showed that ApGltn sealant demonstrated long-term sealing efficacy and safety in a pulmonary air leakage rat model.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Polymer Science
Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Jefferson Aparecido Dias, Maria Angelica Miglino, Daniel de Bortoli Teixeira, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Rodrigues da Cunha, Rogerio Leone Buchaim
Summary: Fibrin, a biopolymer derived from proteins involved in blood clotting, has various applications in the health area. Its combination with photobiomodulation (PBM) can stimulate cell activity, angiogenesis, osteoblast activation, and collagen synthesis.
Article
Surgery
Bahman Darkahi, Torgny Norden, Gabriel Sandblom
Summary: The study aimed to assess the safety of using fibrin sealant on the CBD incision. Although there were no significant differences in operative time and bile flow, the study suggests that incision closure may be an option to reduce the risk of leakage. Further studies are needed to confirm this finding.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Medicine, Research & Experimental
Christina Nikolaou, Maximos Frountzas, Vasilios Pergialiotis, Despina N. Perrea, Konstantinos Kontzoglou, Dimitrios Schizas, Stylianos Kykalos, Dimitrios C. Iliopoulos
Summary: Burn is a complex pathophysiologic phenomenon and novel therapeutic approaches are needed. TISSEELTM, a fibrin sealant, can be an alternate treatment for burn management in areas without specialized burn departments or surgeons, preventing acute consequences.
MEDICAL HYPOTHESES
(2023)
Article
Gastroenterology & Hepatology
Christopher B. Nahm, Irinel Popescu, Florin Botea, Stephen Fenwick, Constantine Fondevila, Itxarone Bilbao, Daniel Reim, Giles J. Toogood
Summary: This study confirms the safety, efficacy, and ease of use of PuraStat (R) in the management of bleeding in liver surgery.
Review
Cell Biology
Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Karina Torres Pomini, Marcia Zilioli Bellini, Eliana de Souza Bastos Mazuqueli Pereira, Carlos Henrique Bertoni Reis, Joao Paulo Galletti Pilon, Miguel Angelo de Marchi, Beatriz Flavia de Moraes Trazzi, Willian Saranholi da Silva, Marcelo Rodrigues da Cunha, Daniela Vieira Buchaim, Rogerio Leone Buchaim
Summary: Cell-based therapy, specifically combining MSCs with fibrin glue, shows potential for nerve regeneration and functional recovery.
Article
Pharmacology & Pharmacy
Luis Fernandez-Vega-Cueto, Mairobi Persinal-Medina, Natalia Vazquez, Manuel Chacon, Belen Alfonso-Bartolozzi, Sergio Alonso-Alonso, Teresa Sanchez, Silvia Berisa-Prado, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: The study proposes a method to prepare autologous bio-based fibrin glue for ophthalmic surgery. The adhesive strength of FG increased with fibrinogen concentration, and FG2 and FG3 showed successful results in conjunctival autografts with equivalent properties compared to commercial FG and reduced inflammation.
Article
Multidisciplinary Sciences
Yueyi Sun, Oluwamayokun Oshinowo, David R. Myers, Wilbur A. Lam, Alexander Alexeev
Summary: Blood clot contraction plays a crucial role in wound healing and hemostasis. This study investigates the relationship between single platelet forces and macroscopic clot forces, providing insights into blood disorders associated with bleeding and thrombosis. The findings contribute to the development of platelet-based biomaterials and facilitate the understanding of clotting mechanisms.
Article
Biochemistry & Molecular Biology
Federica Marinaro, Joana M. Silva, Alexandre A. Barros, Ivo M. Aroso, Juan C. Gomez-Blanco, Isaac Jardin, Jose J. Lopez, Maria Pulido, Maria angeles de Pedro, Rui L. Reis, Francisco Miguel Sanchez-Margallo, Javier G. Casado, Esther Lopez
Summary: This study outlines a new approach to enhance the viability and adhesion of human menstrual blood-derived mesenchymal stromal cells (MenSCs) on polypropylene surgical meshes. By optimizing a multilayered fibrin coating on the meshes, the study showed that MenSCs maintained their viability, adhesion, phenotype, gene expression, and immunomodulatory capacity, while reducing T cell proliferation. This proposed fibrin coating may have potential for reducing inflammatory responses following mesh implantation surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yan Huang, Yihuai Hu, Yaobin Lin, Jianhua Fu, Jiadi Wu, Caiyan Fang, Min Liu, Yang Hong
Summary: This study demonstrated that intraoperative application of fibrin sealant can reduce the incidence of cervical anastomotic leakage after esophagectomy, serving as a safe and effective preventive measure.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Orthopedics
Arya Amirhekmat, Wendy E. Brown, Evelia Y. Salinas, Jerry C. Hu, Kyriacos A. Athanasiou, Dean Wang
Summary: The mechanical properties of fibrin sealants for intra-articular surgical fixation of cartilage fragments and implants were investigated in this study. The adhesive properties of the sealants were not affected by the type or number of applications, but were found to be less than desired for cartilage repair implants. These findings highlight the need for improved cartilage-specific adhesives for cartilage repair applications.
Article
Engineering, Biomedical
Raffael Reichsoellner, Philipp Heher, Jaana Hartmann, Stefan Manhartseder, Rahul Singh, Heinz Gulle, Paul Slezak
Summary: Fibrin sealants are widely used in surgery, and the physicochemical and biological characteristics of two commonly used sealants have been compared. Hyperosmolality in the sealant formulation can trigger apoptosis and the choice of the appropriate sealant system affects clinical outcomes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Education, Scientific Disciplines
Andrey A. Karpenko, Alexey Cheban, Artem A. Rabtsun, German Y. Sokurenko, Konstantin A. Andreychuk, Igor N. Kim, Valentin A. Volf, Maksim R. Kuznetsov, Igor I. Prostov, Natalia G. Sapronova, Nina D. Mzhavanadze, Alexey A. Kamaev, Igor A. Suchkov
Summary: This study compared the efficacy and safety of TISSEEL Lyo fibrin sealant and Manual Compression (MC) as a haemostatic agent in vascular surgery in Russia. The results showed that TISSEEL Lyo was superior to MC in achieving haemostasis at 4, 6, and 10 minutes, and it was also proven to be safe.
Article
Gastroenterology & Hepatology
Sanjay Pandanaboyana, John Moir, John S. Leeds, Kofi Oppong, Aditya Kanwar, Ahmed Marzouk, Ajay Belgaumkar, Ajay Gupta, Ajith K. Siriwardena, Ali Raza Haque, Altaf Awan, Anita Balakrishnan, Arab Rawashdeh, Bogdan Ivanov, Chetan Parmar, Christopher M. Halloran, Clifford Caruana, Cynthia-Michelle Borg, Dhanny Gomez, Dimitrios Damaskos, Dimitrios Karavias, Guy Finch, Husam Ebied, James K. Pine, James R. A. Skipworth, James Milburn, Javed Latif, Jeyakumar Ratnam Apollos, Jihene El Kafsi, John A. Windsor, Keith Roberts, Kelvin Wang, Krish Ravi, Maria Coats, Marianne Hollyman, Mary Phillips, Michael Okocha, Michael S. J. Wilson, Nadeem A. Ameer, Nagappan Kumar, Nehal Shah, Pierfrancesco Lapolla, Connor Magee, Bilal Al-Sarireh, Raimundas Lunevicius, Rami Benhmida, Rishi Singhal, Srinivasan Balachandra, Semra Demirli Atici, Shameen Jaunoo, Simon Dwerryhouse, Tamsin Boyce, Vasileios Charalampakis, Venkat Kanakala, Zaigham Abbas, Manu Nayar
Summary: Patients with acute pancreatitis and coexistent SARS-CoV-2 infection are at higher risk of developing severe pancreatitis, acute respiratory distress syndrome (ARDS), prolonged hospital stays, and increased 30-day mortality.
Article
Gastroenterology & Hepatology
Khaled Ammar, John S. Leeds, Chathura Bb Ratnayake, Gourab Sen, Jeremy J. French, Manu Nayar, Kofi W. Oppong, Benjamin Pt Loveday, Sanjay Pandanaboyana
Summary: This study analyzed four RCTs and found that the use of PERT in APC patients did not significantly affect OS, weight change, or quality of life. However, due to non-uniform designs, different endpoints, and a smaller number of patients, more RCTs are needed to support routine use of PERT in APC.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Surgery
Navamayooran Thavanesan, Bert Van Der Werf, Adil Shafi, Colette Kennedy, Greg O'Grady, Benjamin Loveday, Sanjay Pandanaboyana
Summary: A model predicting the technical and clinical success of embolization in digital subtraction angiography (DSA) for lower gastrointestinal bleed (LGIB) was developed, with activated partial thromboplastin time and time from CT to DSA being significant factors. A triaging approach for emergency DSA was suggested for different clinical scenarios.
ANZ JOURNAL OF SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L. Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A. Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D. Pavelko, David Dolan, Helen L. Reeves, Sushma Grellscheid, Colin H. Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L. Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L. Kirkland, Diana Jurk, Derek A. Mann, Joao F. Passos
Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.
Review
Surgery
Kirsten Larkins, Alistair Rowcroft, Sanjay Pandanaboyana, Benjamin P. T. Loveday
Summary: L-RAMPS surgery is underreported in the literature, with no direct comparison data available between O-RAMPS and L-RAMPS. Reports on L-RAMPS show acceptable oncological and safety profiles.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Gastroenterology & Hepatology
Eric Chong, Bathiya Ratnayake, Shiela Lee, J. Jeremy French, Colin Wilson, J. Keith Roberts, P. T. Benjamin Loveday, Derek Manas, John Windsor, Steve White, Sanjay Pandanaboyana
Summary: This meta-analysis identified smoking and open DP as risk factors and diabetes as a protective factor for CR-POPF following distal pancreatectomy, based on the 2016 ISGPF definition. However, substantial heterogeneity was observed in comparisons of pancreatic texture and body mass index.
Review
Surgery
Chris Varghese, Cameron Iain Wells, Shiela Lee, Samir Pathak, Ajith K. Siriwardena, Sanjay Pandanaboyana
Summary: According to the definition by the International Study Group on Pancreatic Surgery, the incidence of chyle leak after pancreatic surgery is 6.8%, and the incidence of clinically relevant chyle leak is 5.5%. Multiple risk factors for chyle leak were identified in the study.
Review
Surgery
Nasreen Akter, Bathiya Ratnayake, Daniel B. Joh, Sara-Jane Chan, Emily Bonner, Sanjay Pandanaboyana
Summary: This systematic review compared the use of epidural analgesia (EDA), patient controlled analgesia (PCA), and transabdominal wound catheters (TAWC) in pancreatic surgery. The results showed that EDA, PCA, and TAWC are comparable in providing pain relief and perioperative outcomes.
WORLD JOURNAL OF SURGERY
(2021)
Review
Gastroenterology & Hepatology
Ruelan Furtado, Osamu Yoshino, Vijayaragavan Muralidharan, Marcos Perini, Stephen J. Wigmore
Summary: Hepatectomy after bile duct injury is a rare but important procedure for the management of vasculo-biliary injury. It can effectively alleviate symptoms in the majority of cases, although postoperative bile leaks and intra-abdominal infection are common.
Article
Education, Scientific Disciplines
Emma E. Howie, Harini Dharanikota, Eilidh Gunn, Olivia Ambler, Roger Dias, Stephen J. Wigmore, Richard J. E. Skipworth, Steven Yule
Summary: This article highlights the importance of considering Cognitive Load (CL) and Cognitive Load Theory (CLT) in surgical training to enhance current strategies and surgical performance. Feedback and assessment methods in surgical training are subjective and at risk of bias, but Surgical Sabermetrics aims to provide objective, real-time feedback through the analysis of surgical and audio-visual data. Real-time measurement of CL can enhance feedback and improve surgical performance. The principles of Cognitive Load and Surgical Sabermetrics can contribute to making surgical training better and providing higher quality care for patients.
JOURNAL OF SURGICAL EDUCATION
(2023)
Review
Oncology
Harry V. M. Spiers, Francesco Lancellotti, Nicola de Liguori Carino, Sanjay Pandanaboyana, Adam E. Frampton, Santhalingam Jegatheeswaran, Vinotha Nadarajah, Ajith K. Siriwardena
Summary: This study provides a systematic review of irreversible electroporation (IRE) for the treatment of colorectal hepatic metastases. The findings suggest that IRE can be a safe and effective treatment option with low morbidity and mortality rates. Further research is needed to determine the role of IRE in the overall treatment approach for colorectal liver metastases.
Article
Oncology
Leo R. Brown, Michael I. Ramage, Ross D. Dolan, Judith Sayers, Nikki Bruce, Lachlan Dick, Sharukh Sami, Donald C. McMillan, Barry J. A. Laird, Stephen J. Wigmore, Richard J. E. Skipworth
Summary: This study aimed to assess CT body composition in patients who had anastomotic leak post-oesophagectomy. The results showed that skeletal muscle index decreased and subcutaneous fat area increased following neoadjuvant treatment and anastomotic leak. Although tissue radiodensity and subcutaneous fat area normalized on late follow-up scans, skeletal muscle index remained below pre-treatment levels.
Review
Medicine, General & Internal
David Martin, Piero Alberti, Stephen J. Wigmore, Nicolas Demartines, Gaetan-Romain Joliat
Summary: Pancreatic cancer is a deadly disease with unknown origins and limited treatment options. Surgical resection, the primary curative treatment, is associated with high morbidity and mortality rates and frequent recurrence. Patient-centered care and understanding patient perspectives are crucial for improving outcomes in pancreatic cancer surgery. Standardized patient-reported outcome and experience measures are needed to assess patient perspectives accurately.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
C. Varghese, S. Bhat, T. H-H Wang, G. O'Grady, S. Pandanaboyana
Summary: Based on existing RCT evidence, a pylorus-resecting, antecolic, Billroth II with Braun enteroenterostomy seems to be associated with the lowest rates of delayed gastric emptying (DGE) after pancreaticoduodenectomy.
Article
Gastroenterology & Hepatology
Manu K. Nayar, Noor L. H. Bekkali, David Bourne, Sophie Young, John S. Leeds, Kofi W. Oppong, Jennifer L. Logue, Gourab Sen, Jeremy J. French, John Scott, David Cressey, Sanjay Pandanaboyana, Richard M. Charnley
Summary: This study examines the management of severe acute pancreatitis within the UK's pancreatitis network. It found that some patients required referral to a specialist center, mainly for drainage of pancreatic fluid collections. Transferred patients had significantly longer overall hospital stay but less time in the intensive care unit.
BMJ OPEN GASTROENTEROLOGY
(2021)