Article
Surgery
Nai-Qing Ma, Hao-Yang Lv, Jiayang Bi, Fu-Xiang Yu, Xia-Ming Huang
Summary: A scoring system based on cross-sectional area of gallbladder polyps and other clinical indicators has been developed to accurately identify true polyps, helping to determine the need for surgical resection and reduce unnecessary surgical risks.
ASIAN JOURNAL OF SURGERY
(2022)
Review
Oncology
Benita C. Y. Tse, Zoe Welham, Alexander F. Engel, Mark P. Molloy
Summary: Colorectal cancer (CRC) originates from pre-cancerous cell lesions in the gut known as polyps, which are formed through the accumulation of mutations disrupting tumor suppressor genes. Colonoscopic surveillance and polypectomy are essential for early detection and prevention of CRC. Recent advances in genomic sequencing have provided insights into key mutations in polyps and the potential role of early immunological and microbial changes in CRC development.
Review
Radiology, Nuclear Medicine & Medical Imaging
Aya Kamaya, Christopher Fung, Jean-Luc Szpakowski, David T. Fetzer, Andrew J. Walsh, Yewande Alimi, David B. Bingham, Michael T. Corwin, Nirvikar Dahiya, Helena Gabriel, Walter G. Park, Matthew R. Porembka, Shuchi K. Rodgers, Mitchell E. Tublin, Xin Yuan, Yang Zhang, William D. Middleton
Summary: Gallbladder polyps are common incidental findings, with the majority of polyps smaller than 10 mm being benign cholesterol polyps without inherent malignancy risk. Recent studies have questioned the rationale for frequent and prolonged follow-up of small gallbladder polyps, as they do not appear to increase the overall risk of gallbladder cancer. In 2021, the Society of Radiologists in Ultrasound convened a consensus conference to provide recommendations for the management of incidentally detected gallbladder polyps.
Article
Surgery
Qi Li, Jingwei Zhang, Zhiqiang Cai, Pengbo Jia, Xintuan Wang, Xilin Geng, Yu Zhang, Da Lei, Junhui Li, Wenbin Yang, Rui Yang, Xiaodi Zhang, Chenglin Yang, Chunhe Yao, Qiwei Hao, Yimin Liu, Zhihua Guo, Shubin Si, Zhimin Geng, Dong Zhang
Summary: A Bayesian network prediction model was developed to predict gallbladder polyps (GPs) with malignant potential. The study identified factors such as age, number of polyps, and polyp size that were associated with the malignant potential of GPs. The model showed good performance on both training and testing sets and provided a grading system for patients based on preoperative ultrasound.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Shahab Hajibandeh, Sana Ashar, Craig Parry, Rwth Ellis-Owen, Nagappan Kumar
Summary: The aim of this study was to determine the risk and predictors of gallbladder cancer in patients with gallbladder polyps. The study found that the size of the polyps was the only predictor of malignant changes, while age, symptoms, and number of polyps did not affect the risk. Additionally, the growth rate of the polyps was slow and a significant proportion disappeared during follow-up.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Tamotsu Sugai, Mitsumasa Osakabe, Takeshi Niinuma, Ryo Sugimoto, Makoto Eizuka, Yoshihito Tanaka, Naoki Yanagawa, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Hiromu Suzuki
Summary: This study identified specific miRNA/mRNA networks that contribute to the progression of colorectal tumors, providing insights into the molecular tumorigenesis of these tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yuki Fukumura, Lu Rong, Yifare Maimaitiaili, Toshio Fujisawa, Hiroyuki Isayama, Jun Nakahodo, Masataka Kikuyama, Takashi Yao
Summary: Understanding the pathogenesis and carcinogenesis of gallbladder adenocarcinoma is crucial. This study reviewed and summarized information on three gallbladder neoplastic precursors, PGA, BilIN, and ICPN, as well as gallbladder lesions in patients with PBM.
Article
Oncology
Yael Berger, Brianne J. Sullivan, Natasha L. Leigh, Eliahu Y. Bekhor, Pooja Dhorajiya, Malary Mani, Deepa R. Magge, Da Eun Cha, Umut Sarpel, Spiros P. Hiotis, Daniel M. Labow, Stephen C. Ward, Benjamin J. Golas, Noah A. Cohen
Summary: This study retrospectively analyzed the histological subtypes and prognosis of gallbladder cancer. The results showed that biliary-type adenocarcinoma (BTA) was the most common subtype, and tumors arising from intracholecystic papillary-tubular neoplasms (ICPNs) were often associated with BTA. BTAs not associated with ICPNs had higher pathological stages and rates of liver and perineural invasion. Patients with gallbladder neoplasms associated with ICPNs had a higher 5-year survival probability compared to those without ICPNs. These findings can help guide clinical decision making for the treatment of these patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lianhua Zhu, Peng Han, Regis Lee, Bo Jiang, Ziyu Jiao, Nan Li, Wenbo Tang, Xiang Fei
Summary: The study evaluated the value of CEUS in distinguishing adenomatous gallbladder polyps from cholesterol gallbladder polyps and found that vascular stalk width measured by CEUS is more accurate in differentiation. Vascular stalk width and vascularity were identified as independent factors related with adenomatous polyps.
Article
Gastroenterology & Hepatology
Timothy O'Sullivan, David Tate, Mayenaaz Sidhu, Sunil Gupta, James Elhindi, Karen Byth, Oliver Cronin, Anthony Whitfield, Ana Craciun, Rajvinder Singh, Gregor Brown, Spiro Raftopoulos, Luke Hourigan, Alan Moss, Amir Klein, Steven Heitman, Stephen Williams, Eric Lee, Nicholas G. Burgess, Michael J. Bourke
Summary: This study investigated the relationship between large nonpedunculated colorectal polyps (LNPCPs) and synchronous colonic LNPCPs, revealing that 6.9% of LNPCPs had synchronous lesions with a greater than 4-fold increased risk for non-granular LNPCPs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Hanju Hua, Yanhong Sun, Xinjue He, Yi Chen, Lisong Teng, Chao Lu
Summary: This study investigated the characteristics of intestinal microbiota in patients with colorectal adenoma and carcinoma and its correlations with clinical characteristics. The results showed that certain intestinal bacteria changed along the adenoma-carcinoma sequence and could be potential markers for the diagnosis and treatment of colorectal adenoma/carcinoma.
FRONTIERS IN MEDICINE
(2022)
Review
Acoustics
Christian Jenssen, Torben Lorentzen, Christoph F. Dietrich, Jae Young Lee, Nitin Chaubal, Buyng Ihn Chol, Jacob Rosenberg, Carsten Gutt, Christian P. Nolsoe
Summary: The World Federation of Ultrasound in Medicine and Biology (WFUMB) is addressing the issue of incidental findings in the biliary system with a series of position papers. This first part of the position paper provides a summary of available evidence on prevalence, diagnostic work-up, malignancy risk, follow-up, and treatment of gallbladder polyps and other incidental findings of the gallbladder wall, with a special focus on ultrasound techniques. It suggests the inclusion of multi-parametric ultrasound features in assessing malignancy risk and making decisions on further management.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Surgery
Qi Li, Minghui Dou, Jingwei Zhang, Pengbo Jia, Xintuan Wang, Da Lei, Junhui Li, Wenbin Yang, Rui Yang, Chenglin Yang, Xiaodi Zhang, Qiwei Hao, Xilin Geng, Yu Zhang, Yimin Liu, Zhihua Guo, Chunhe Yao, Zhiqiang Cai, Shubin Si, Zhimin Geng, Dong Zhang
Summary: A Bayesian network prediction model was developed to identify neoplastic polyps and create precise surgical indications for patients with gallbladder polyps larger than 10 mm based on preoperative ultrasound features. The accuracy of the model was 81.88% and 82.35% in the training and testing sets, respectively, outperforming other guidelines.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Walsh, David B. Bingham, Aya Kamaya
Summary: This study aimed to assess the longitudinal changes in the number and size of gallbladder polyps on serial ultrasound examinations. The results showed that gallbladder polyps fluctuated in size, number, and visibility over time, suggesting that the current guidelines for surveillance and cholecystectomy may be too conservative.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sergei Vosko, Neal Shahidi, Mayenaaz Sidhu, W. Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Karen Byth, Eric Y. T. Lee, Nicholas G. Burgess, Michael J. Bourke
Summary: This study found significant differences in optical evaluation performance between flat and nodular large nonpedunculated colorectal polyps. Flat lesions can be presumed benign and managed accordingly, while nodular lesions are more likely to be missed for submucosal invasive cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)