Review
Endocrinology & Metabolism
Carolina Echeverria, Francisco Nualart, Luciano Ferrada, Gary J. Smith, Alejandro S. Godoy
Summary: This passage discusses how cancer cells increase their metabolic activity by overexpressing hexose transporters, focusing mainly on glucose uptake. It points out a significant gap in our understanding of the role of other hexoses and DHA in cancer biology, while summarizing recent advances in understanding the multifunctional transport capacity of Gluts in cancer biology and clinical aspects.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Matthew S. Crouse, Kyle J. McLean, Josephine Dwamena, Tammi L. Neville, Ana Clara B. Menezes, Alison K. Ward, Lawrence P. Reynolds, Carl R. Dahlen, Bryan W. Neville, Pawel P. Borowicz, Joel S. Caton
Summary: The study revealed that maternal nutrition during early pregnancy affects the abundance of glucose and amino acid transporters in heifer uteroplacental tissues. Different nutritional treatments and gestation days lead to variations in transporter abundance in different tissue compartments.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Piotr Hapeta, Patrycja Szczepanska, Tadeusz Witkowski, Jean-Marc Nicaud, Anne-Marie Crutz-Le Coq, Zbigniew Lazar
Summary: The translation explores the use of molasses as a substrate for bioprocesses, focusing on the role of hexose transporters and hexokinase in glucose preference in Yarrowia lipolytica. Overexpression of hexokinase with hexose transporters accelerated citric acid biosynthesis and enhanced pentose phosphate pathway, leading to increased production of polyols. Additionally, overexpression of fructophilic hexokinase resulted in a shorter processing time and higher polyol yield compared to the glycerol medium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Maria E. Tecos, Allie E. Steinberger, Jun Guo, Brad W. Warner
Summary: This study optimized a highly selective vascular approach to murine ileocecal resection (ICR), which showed superior colon preservation and enhanced remnant intestine epithelial adaptation compared to proximal small bowel resection (SBR). The findings suggest that ICR is associated with greater colonic adaptation and unique plasticity toward an intestinal phenotype.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Palsa Kondaiah, Ravindranadh Palika, Purnachandra Mashurabad, Puneeta Singh Yaduvanshi, Paul Sharp, Raghu Pullakhandam
Summary: The study demonstrates that zinc depletion leads to reduced intestinal iron absorption, body weight, and tissue iron levels, while zinc repletion can reverse these effects but may cause a decrease in hemoglobin levels and red blood cell number. Zinc status plays a significant role in influencing growth, iron absorption, and systemic iron utilization.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Baolin Huang, Zimin Lin, Zhenzhen Chen, Jiasheng Chen, Birui Shi, Jingjing Jia, Yuan Li, Yueqing Pan, Yuntao Liang, Zheng Cai
Summary: Designing oral drug delivery systems using intestinal glucose transporters (IGTs) is a potential strategy for improving oral bioavailability of drugs. However, the biological factors affecting the drug transport capacity of IGTs are not well understood. This study demonstrated that gastrodin, a sedative drug with a structure similar to glucose, is absorbed via the intestinal glucose transport pathway and can be used to evaluate the drug transport capacity of IGTs. Different strains of rats and mice showed variation in the drug transport capacity of IGTs, with SD rats and C57 mice being more suitable for evaluating the pharmacokinetics of glycosides' active ingredients absorbed via the intestinal glucose transport pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Cell Biology
Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv, Xiaobo Wang, Yadan Zhong, Hongxin Huang, Xin Zhang, Shufeng Ma, Bin Yang, Xiaohua Wang, Zhili Rong
Summary: SLC35E1 is highly expressed in keratinocytes of psoriasis patients, and its deficiency inhibits keratinocyte proliferation. The regulation of zinc ion concentrations and supplementation can alleviate psoriasis symptoms, indicating a potential therapy for psoriasis.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Rong Lu, Yun Zhou, Jinqian Ma, Yuchen Wang, Xiaoqing Miao
Summary: This review focuses on intestinal efflux transporters that actively transport drugs from the enterocytes to the intestinal lumen, leading to poor absorption of orally-administered drugs. Various functional amphiphilic excipients and inhibitors that can suppress efflux transporter activity are discussed with the aim of reversing intestinal drug efflux and improving oral drug absorption. Different strategies of reducing intestinal drug efflux and various nano-formulations for improving oral drug absorption by inhibiting intestinal drug efflux are explored.
Article
Medicine, Research & Experimental
Onur Cil, Tifany Chu, Sujin Lee, Peter M. Haggie, Alan S. Verkman
Summary: SLC26A3 plays a major role in intestinal oxalate absorption, and inhibiting SLC26A3 can be used to treat hyperoxaluria and prevent calcium oxalate nephrolithiasis.
Article
Multidisciplinary Sciences
Emily J. Onufer, Rafael S. Czepielewski, Yong-Hyun Han, Cathleen M. Courtney, Stephanie Sutton, Anne Sescleifer, Gwendalyn J. Randolph, Brad W. Warner
Summary: This study found that functional transport of intestinal lipids significantly decreased after small bowel resection, with an increase in fecal fat content. Besides, significant morphological changes in the lymphatic vasculature were observed. Chronic short bowel syndrome leads to significant remodeling of the intestinal lymphatic vessels.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Tomohisa Kitagawa, Atsushi Matsumoto, Ichiro Terashima, Yukifumi Uesono
Summary: Quinacrine and chloroquine show antimicrobial and antiviral activities, with an exponential increase in antimicrobial activity due to pH-dependent changes in cationic amphiphilic drug (CAD) structure. However, decreased effectiveness is observed in patients with acidosis, suggesting the importance of restoring normal blood pH or using pH-insensitive drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Weiwei Tang, Yuejie Zhang, Ping Li, Bin Li
Summary: In this study, an integrated strategy combining quadruple single-pass intestinal perfusion (Q-SPIP) technique and matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) was developed for in situ visualization and assessment of drug absorption and interaction in rat intestines. The Q-SPIP model enabled simultaneous perfusion of four individual segments of each rat intestine, providing rich data for analysis. The optimized MALDI MSI approach accurately visualized the drug distribution and absorption in rat intestinal tissue. The findings demonstrate the utility and versatility of Q-SPIP coupled with MALDI MSI in studying transporter-mediated intestinal drug absorption and interaction.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Sedzikowska, Leszek Szablewski
Summary: The kidney plays a crucial role in glucose homeostasis by releasing glucose into the blood stream using carrier proteins for transport. Mutations in genes encoding glucose transporters can lead to renal disorders, impacting glucose transport and renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Weiwei Tang, Yuejie Zhang, Ping Li, Bin Li
Summary: Visualization and characterization of intestinal membrane transporter-mediated drug absorption and interaction are challenging. A new integrated strategy using quadruple single-pass intestinal perfusion (Q-SPIP) technique coupled with matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) was developed for in situ visualization and assessment of drug absorption and interaction in rat intestines. The utility and versatility of this strategy were demonstrated through the examination of P-glycoprotein (P-gp)-mediated intestinal absorption of berberine (BBR) and its combination with natural products possessing inhibitory potency against P-gp.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
David Malnoe, Olivier Fardel, Pascal Le Corre
Summary: This study proposes a method to suggest the involvement of intestinal transporters in DDIs by analyzing the variations in mean absorption time. Significant variations in absorption time were found in 33 out of 77 DDI studies, with 12 attributed to modulation of efflux transporters.