Article
Gastroenterology & Hepatology
Kang Nyeong Lee, Oh Young Lee, Hoon Jai Chun, Jin Il Kim, Sung Kook Kim, Sang Woo Lee, Kyung Sik Park, Kook Lae Lee, Suck Chei Choi, Jae-Young Jang, Gwang Ha Kim, In-kyung Sung, Moo In Park, Joong Goo Kwon, Nayoung Kim, Jae Jun Kim, Soo Teik Lee, Hyun Soo Kim, Ki Bae Kim, Yong Chan Lee, Myung-Gyu Choi, Joon Seong Lee, Hwoon-Yong Jung, Kwang Jae Lee, Jie-Hyun Kim, Hyunsoo Chung
Summary: Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in healing erosive esophagitis at week 8. The study suggests that Fexuprazan may be a promising alternative treatment option to PPIs for patients with erosive esophagitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Medicine, General & Internal
N. J. Talley, M. Zand Irani
Summary: Gastroesophageal reflux disease (GERD) is a common disorder that may not respond to initial proton pump inhibitor (PPI) treatment, and refractory reflux can be challenging to manage. Differential diagnosis is crucial in order to tailor appropriate therapy, and a combination of clinical assessment and testing can help characterize patients for targeted treatment. Newer approaches, such as endoscopic techniques, are being explored as alternative options for refractory reflux.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler
Summary: This study found that vonoprazan, a potassium-competitive acid blocker, was noninferior and superior to the PPI lansoprazole in healing and maintenance of erosive esophagitis, particularly in patients with more severe cases.
Article
Gastroenterology & Hepatology
Lucas Wauters, Matthias Ceulemans, Dennis Frings, Maarten Lambaerts, Alison Accarie, Joran Toth, Raf Mols, Patrick Augustijns, Gert De Hertogh, Lukas Van Oudenhove, Jan Tack, Tim Vanuytsel
Summary: This study found that the numbers of eosinophils and immune cells in the duodenum, as well as permeability, were significantly higher in patients with functional dyspepsia, and decreased after PPI therapy. In contrast, immune cells and permeability increased in healthy volunteers on PPIs.
Article
Biochemistry & Molecular Biology
Lucas Wauters, Raul Y. Tito, Matthias Ceulemans, Maarten Lambaerts, Alison Accarie, Leen Rymenans, Chloe Verspecht, Joran Toth, Raf Mols, Patrick Augustijns, Jan Tack, Tim Vanuytsel, Jeroen Raes
Summary: The study found differential mucus-associated genera between FD patients and controls, with Streptococcus positively correlating with duodenal eosinophils in controls. While short-term PPI therapy effects were unrelated to changes in the gut microbiota for FD patients, increased Streptococcus in controls was associated with duodenal PPI effects, even after long-term therapy withdrawal in FD stoppers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Saad Alkhowaiter
Summary: Eosinophilic esophagitis is an atopic disease characterized by eosinophil infiltration in the esophageal mucosa, resulting in various upper gastrointestinal symptoms. The condition is chronic and can lead to subepithelial fibrosis and esophageal stenosis if left untreated. Diagnosis of EoE is confirmed through characteristic symptoms, signs on endoscopy, and biopsy results. Effective treatments include PPIs, topical steroids, elimination diet, and novel biologics such as dupilumab.
SAUDI MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Sara Kamionkowski, Fahmi Shibli, Stephen Ganocy, Ronnie Fass
Summary: The study found that adults with autism spectrum disorder (ASD) are more likely to have gastroesophageal reflux disease (GERD) and experience complications such as erosive esophagitis and esophageal ulcers. Treatment for GERD in patients with ASD is inconsistent, suggesting potential healthcare disparities.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Yorinari Ochiai, Toshiro Iizuka, Yoshio Hoshihara, Yugo Suzuki, Junnosuke Hayasaka, Kosuke Nomura, Masami Tanaka, Hiroyuki Odagiri, Satoshi Yamashita, Akira Matsui, Daisuke Kikuchi, Masaki Ueno, Harushi Udagawa, Shu Hoteya
Summary: This study aimed to investigate the efficacy of VPZ in treating PPI-resistant RRE after esophagectomy with gastric pull-up. Clinical observations showed that the percentage of patients with improved mucosa and mucosal healing in the VPZ group was significantly higher compared to the PPI group.
DIGESTIVE DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Feng Liu, Chao Shou, Qiang Geng, Chen Zhao, Jianhe Xu, Huilei Yu
Summary: The study utilized the BoBVMO sequence as a probe to identify seven new BVMOs with the highest efficiency and excellent enantioselectivity for converting LPS into (R)-lansoprazole, suggesting CbBVMO as a potential enzyme for extending the application of BVMOs in the pharmaceutical industry.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Immunology
Jihang Du, Yinhao Feng, Qiang Yuan, Haiping Gong, Jie An, Liu Wu, Qian Dai, Bojun Xu, Haozhong Wang, Jian Luo
Summary: This study highlighted that acupuncture could significantly improve the overall therapeutic effect of patients with postprandial distress syndrome (PDS), alleviate the symptoms of postprandial fullness and early satiety, and improve the quality of life of patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Rachel Rosen
Summary: The treatment of gastroesophageal reflux varies greatly in different age groups of children. Nutritional interventions are commonly used for infants, while medications are more frequently utilized for older children. However, if treatment does not produce the desired results, it is important to reassess the diagnosis being treated and conduct additional testing to provide a more precise approach to care.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Alexander M. Kaizer, Daniel R. Sikavi, Madeline Greytak, Jennifer X. Cai, Thomas L. Carroll, Samir Gupta, Sachin Wani, Paul Menard-Katcher, Tsung-Chin Wu, Philip Weissbrod, Andrew M. Vahabzadeh-Hagh, John E. Pandolfino, Walter W. Chan
Summary: The study identified different clinicophysiologic phenotypes of patients with laryngeal symptoms referred for reflux evaluation, including LPR and GERD with hiatal hernia, mild LPR/GERD, no LPR/No GERD, reflex cough, and mixed/possible obstructive esophagogastric junction, which may inform targeted clinical trial design and improve outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pathology
Meredith E. Pittman
Summary: This review summarizes the current understanding of lymphocytic esophagitis (LE), a novel form of chronic esophagitis that incorporates distinctive histologic, clinical, and endoscopic features.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Gastroenterology & Hepatology
A. Pali S. Hungin, Carmelo Scarpignato, Laurie Keefer, Maura Corsetti, Foteini Anastasiou, Jean W. M. Muris, Juan M. Mendive, Peter J. Kahrilas
Summary: This article discusses the management of reflux-like symptoms, emphasizing the importance of considering the perceptual causes and providing appropriate interventions early in the management process. In addition to medication, psychological counseling and symptom-specific behavioral interventions should be offered to patients with somatization or disorders of gut-brain interaction. Lifestyle and dietary advice should also be integrated into care at an early stage.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Noriaki Manabe, Takatoki Yamamoto, Michiya Matsusaki, Mitsuru Akashi, Ken Haruma
Summary: This study aimed to validate a new method of bioelectrical admittance measurement and investigate its potential for evaluating treatment response in patients with gastroesophageal reflux disease. The results suggest that bioelectrical admittance measurement could be a valuable tool for assessing mucosal permeability and treatment response in various gastrointestinal diseases in the future.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)