Article
Gastroenterology & Hepatology
Wan-Ting Cao, Rong Huang, Shan Liu, Yi-Hong Fan, Mao-Sheng Xu, Yi Xu, Hui Ni
Summary: This study aimed to explore the predictive value of infliximab trough level (ITL) in combination with inflammatory biomarkers on long-term endoscopic outcomes in Crohn's disease (CD) patients during infliximab (IFX) maintenance therapy. The results showed that low ITL and high inflammatory biomarker levels increased the risk of endoscopic activity at different stages of treatment. The combination of ITL and inflammatory biomarkers can moderately predict endoscopic activity. Furthermore, ITL was also associated with endoscopic relapse-free survival.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yiyoung Kwon, Eun-Sil Kim, Yoon-Zi Kim, Yon-Ho Choe, Mi-Jin Kim
Summary: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-alpha) level affected the trough concentration of infliximab (IFX).
Article
Medicine, General & Internal
Ziheng Peng, Duo Xu, Yong Li, Xiaowei Liu, Fujun Li, Yu Peng
Summary: The prognostic nutritional index (PNI) can predict the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD). Low PNI is an independent risk factor for poor IFX effectiveness in CD patients. Attention should be paid to assessing immune and nutritional statuses in CD patients.
ANNALS OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yueying Chen, Feng Jing, Yang Tian, Qiao Yuqi, Shen Jun
Summary: This study aimed to develop a novel nomogram based on bioelectrical impedance analysis (BIA) indexes and laboratory markers to predict secondary loss of response (SLR) to infliximab in biologically naive Crohn's disease patients. The nomogram included predictors such as hemoglobin, albumin, serum iron, and BIA scores, showing significant discrimination, calibration, and net clinicalbenefit within certain risk probability ranges. Internal validation confirmed the robustness of the nomogram with high accuracy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Chenglin Ye, Sizhe Zhu, Jingping Yuan
Summary: This study analyzed the gene expression profiles of patients with Crohn's disease (CD) and identified two gene subtypes: immune and metabolic. The immune subtype was associated with leukocyte migration and cytokine interactions, while the metabolic subtype was associated with metabolic pathways. The combination of interleukin 1 beta, interleukin 6, and Toll-like receptor 4 effectively distinguished between these two gene subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Beatriz Orts, Ana Gutierrez, Lucia Madero, Laura Sempere, Ruben Frances, Pedro Zapater
Summary: There are differences in the immunological profile and clinical evolution of patients with Crohn's disease according to the anti-TNF dose and serum trough levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Medicine, General & Internal
Krystyna Slowinska-Solnica, Dorota Pawlica-Gosiewska, Katarzyna Gawlik, Danuta Owczarek, Dorota Cibor, Halina Pocztar, Tomasz Mach, Bogdan Solnica
Summary: The study aimed to evaluate the diagnostic characteristics of inflammatory markers and their multiplication in diagnosing and assessing Crohn's disease (CD) activity. Results showed that IL-23 may be the best diagnostic performer, while CRP was found to be useful in assessing CD activity.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Immunology
So Yoon Choi, Yiyoung Kwon, Sujin Choi, So Mi Lee, Byung-Ho Choe, Ben Kang
Summary: This study investigated whether infliximab (IFX) trough levels are associated with transmural healing in pediatric patients with Crohn's disease (CD) after 1-year treatment. The results showed that IFX trough levels were associated with endoscopic healing but not with transmural healing in pediatric patients with CD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Bonita Gu, Kavya Venkatesh, Astrid-Jane Williams, Watson Ng, Crispin Corte, Ali Gholamrezaei, Simon Ghaly, Wei Xuan, Sudarshan Paramsothy, Susan Connor
Summary: Maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. Patients who achieved fistula healing had significantly higher drug trough levels compared to those who did not.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Jing Feng, Qi Feng, Yueying Chen, Tian Yang, Saiming Cheng, Yuqi Qiao, Jun Shen
Summary: This study investigated the correlation between R2* and inflammation and developed a non-invasive nomogram based on R2* to identify SLR to infliximab in patients with CD.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Li Li, Rirong Chen, Yingfan Zhang, Gaoshi Zhou, Baili Chen, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: MMP3, CCL2, and CRP are promising biomarkers for predicting PNR to infliximab. A PNR classifier combining these three indicators can accurately predict PNR and may be useful in clinical practice for therapy selection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Brad D. Constant, Salina Khushal, Jiji Jiang, James E. Bost, Ellen Chaisson, Laurie S. Conklin
Summary: In pediatric Crohn's disease, early markers of disease activity are associated with inadequate post-induction infliximab trough concentrations.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Eun Sil Kim, Sujin Choi, So Yoon Choi, Ji Hyung Park, Byung-Ho Choe, Soo-Youn Lee, Mi Jin Kim, Yon Ho Choe, Ben Kang
Summary: NUDT15 intermediate metabolisers are associated with lower loss of response in pediatric patients with CD treated with IFX and AZA combination therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Xiaomei Song, Huihui Zhang, Hao Wang, Zhongyue Li, Xiaoqin Zhou, Hong Guo
Summary: This retrospective cohort study found a correlation between vitamin D levels and response to infliximab therapy in patients with Crohn's disease. Vitamin D levels were positively correlated with disease activity index scores, while infliximab serum trough concentrations were associated with remission and response rates.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2023)
Article
Gastroenterology & Hepatology
Emily K. Wright, Maria Chaparro, Paolo Gionchetti, Amy L. Hamilton, Julien Schulberg, Javier P. Gisbert, Maria Chiara Valerii, Fernando Rizzello, Peter De Cruz, John C. Panetta, Annelie Everts-van der Wind, Michael A. Kamm, Thierry Dervieux
Summary: This study found that adalimumab drug clearance is a critical factor in determining the therapeutic outcome of Crohn's disease patients. Patients with lower drug clearance showed better endoscopic remission, while drug concentration did not significantly differ between patients in remission and those with recurrence. Sustained clinical remission based on C-reactive protein and lower faecal calprotectin levels were generally associated with lower clearance and higher drug concentration.
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Rheumatology
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Gastroenterology & Hepatology
Shintaro Akiyama, Jacob E. Ollech, Victoria Rai, Laura R. Glick, Yangtian Yi, Cindy Traboulsi, Joseph Runde, Russell D. Cohen, Kinga B. Skowron, Roger D. Hurst, Konstantin Umanskiy, Benjamin D. Shogan, Neil H. Hyman, Michele A. Rubin, Sushila R. Dalal, Atsushi Sakuraba, Joel Pekow, Eugene B. Chang, David T. Rubin
Summary: This study developed a new classification system for pouchitis based on the pattern of inflammation observed in pouches. It identified 7 different phenotypes and evaluated the contributing factors and prognosis of each phenotype. The study provides valuable insights for pouch management and future interventional studies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Charles Muller, Akihiro Yamada, Sachie Ikegami, Haider Haider, Yuga Komaki, Fukiko Komaki, Dejan Micic, Atsushi Sakuraba
Summary: Serrated polyposis syndrome (SPS) is an underrecognized CRC predisposition syndrome with a higher risk of colorectal cancer, especially at the time of diagnosis. Early recognition, screening, and enhanced surveillance protocols are crucial in managing the elevated CRC risk in SPS patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anthony Buisson, Lisa Cannon, Konstantin Umanskiy, Roger D. Hurst, Neil H. Hyman, Atsushi Sakuraba, Joel Pekow, Sushila Dalal, Russell D. Cohen, Bruno Pereira, David T. Rubin
Summary: Anti-TNF therapy was found to be the most effective medication in preventing endoscopic and clinical postoperative recurrence (POR) in Crohn's disease (CD). Combination therapy with anti-TNF agents and immunosuppressive drugs should be considered for patients previously exposed to anti-TNF before surgery.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Matthew Peller, Rajesh N. Keswani, Atsushi Sakuraba, Dejan Micic
Summary: The study found that a history of bariatric surgery is a risk factor for inadequate bowel preparation, particularly in patients who have undergone bypass surgery. Therefore, further efforts should be made to identify the appropriate bowel preparation regimen for these patients.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Atsushi Sakuraba, Alexander Luna, Dejan Micic
Summary: The meta-analysis showed that patients with immune-mediated inflammatory diseases have a reduced response to mRNA COVID-19 vaccines, especially those receiving anti-CD20 and anti-tumor necrosis factor therapy. These patients are less likely to achieve a serologic response even after completing the full vaccine series.
Review
Oncology
Atsushi Sakuraba, Alexander Luna, Dejan Micic
Summary: Patients with cancer, especially those with hematologic B-cell malignancies, have a lower serologic response to COVID-19 vaccines. Additional strategies for prophylaxis should be considered for cancer patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Fares Ayoub, Matthew Odenwald, Dejan Micic, Sushila R. Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin, Atsushi Sakuraba
Summary: This article systematically reviewed the effectiveness of vedolizumab for the management of perianal fistulizing CD and conducted a meta-analysis. The results showed that vedolizumab treatment led to healing of perianal fistulas in nearly one-third of the 198 patients included in the study. However, the lack of high-quality data and significant study heterogeneity highlight the need for future prospective studies to evaluate fistula healing in patients receiving anti-integrin therapy.
INTESTINAL RESEARCH
(2022)
Article
Medicine, General & Internal
Nathaniel A. Cohen, Dejan M. Micic, Atsushi Sakuraba
Summary: In this study, mental health disorders and smoking were independently associated with non-compliance to medication in predominantly adolescent, hospitalized pediatric CD patients. A multidisciplinary approach involving pediatric gastroenterologists, psychiatrists, and addiction specialists is needed to treat the underlying causes and improve adherence in these patients.
ANNALS OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Shintaro Akiyama, Jacob E. Ollech, Cindy Traboulsi, Victoria Rai, Laura R. Glick, Yangtian Yi, Joseph Runde, Andrea D. Olivas, Christopher R. Weber, Russell D. Cohen, Kinga B. Skowron Olortegui, Roger D. Hurst, Konstantin Umanskiy, Benjamin D. Shogan, Michele A. Rubin, Sushila R. Dalal, Atsushi Sakuraba, Joel Pekow, Eugene B. Chang, John Hart, Neil H. Hyman, David T. Rubin
Summary: Our study aimed to assess how the histopathology of colectomy specimens predicts endoscopic pouch phenotypes in patients with UC. The results showed that deep inflammation was significantly associated with pouch fistulas, while terminal ileal involvement significantly increased the risk of afferent limb involvement.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Virology
Atsushi Sakuraba, Alexander Luna, Dejan Micic
Summary: The serologic response to the COVID-19 vaccine is extremely low in solid organ transplant recipients, and even the third dose has an insufficient response. Strategies for prophylaxis need to be developed for this vulnerable patient population.
Letter
Rheumatology
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Gastroenterology & Hepatology
Maryam Zafer, Hui Zhang, Sujaata Dwadasi, Donald Goens, Raghavendra Paknikar, Sushila Dalal, Russell D. Cohen, Joel Pekow, David T. Rubin, Atsushi Sakuraba, Dejan Micic
Summary: The predictive factors for colectomy in severe ulcerative colitis include prior biologic exposure, need for inpatient salvage therapy, and younger age. A clinical predictive model based on admission data was developed to identify high-risk patients for one-year colectomy in adults hospitalized for severe UC.
CROHNS & COLITIS 360
(2022)