Article
Medicine, General & Internal
Jan Tilmann Vollrath, Felix Klingebiel, Felix Blasius, Johannes Greven, Eftychios Bolierakis, Aleksander J. Nowak, Marija Simic, Frank Hildebrand, Ingo Marzi, Borna Relja
Summary: Polytrauma and concomitant hemorrhagic shock can lead to intestinal damage and subsequent multiple organ dysfunction syndrome. This study investigates the dynamics of intestinal fatty acid-binding protein (I-FABP) in plasma and urine after polytrauma in a porcine animal model. The results suggest that I-FABP levels in plasma and urine are significantly increased after polytrauma, indicating intestinal damage. Immunohistological staining also shows decreased levels of I-FABP in the intestine of polytraumatized animals compared to sham animals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Maciej Tyszko, Anna Lemanska-Perek, Jakub Smiechowicz, Paulina Tomaszewska, Przemyslaw Biecek, Waldemar Gozdzik, Barbara Adamik
Summary: Gastrointestinal (GI) failure in sepsis can be indicated by changes in biomarkers such as citrulline and I-FABP. Lower citrulline concentrations were observed in septic shock patients compared to non-shock patients. In addition, higher levels of I-FABP were found in septic shock patients on certain days. Patients with GI failure had lower citrulline levels and higher AGI scores, which were associated with increased 28-day mortality. These results suggest that citrulline measurements and AGI assessment have clinical potential in monitoring GI function and integrity in sepsis.
Article
Microbiology
Maciej Tyszko, Malgorzata Lipinska-Gediga, Anna Lemanska-Perek, Katarzyna Kobylinska, Waldemar Gozdzik, Barbara Adamik
Summary: Gastrointestinal symptoms are common in critically ill COVID-19 patients. Assessing intestinal damage in unconscious or sedated ICU patients is challenging. This study reveals that the levels of I-FABP, a biomarker for enterocyte damage, are significantly higher in COVID-19 patients who eventually died, and it can be a predictor of poor outcome.
Article
Surgery
Satoshi Karasawa, Talza-alzi Nalzada, Mamoru Sato, Talzu Miyasho, Tadanaga Shimada, Talzu Oshima, Koichi Suda, Koichiro Shinozalzi, Shigeto Oda
Summary: The study demonstrated that blood levels of cell-free DNA were significantly higher in the AMI model than in sham and abdominal sepsis models, and they were positively correlated with the pathologic ischemia severity score. Additionally, higher levels of paraoxonase-1 were found in the AMI models compared to the abdominal sepsis models, suggesting a potential role in the differential diagnosis of mesenteric ischemia.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Agriculture, Dairy & Animal Science
Elsa K. Ludwig, Kallie J. Hobbs, Caroline A. McKinney-Aguirre, Liara M. Gonzalez
Summary: Biomarkers are measurable substances that can identify ongoing injury or disease. Colic associated with intestinal ischemia is a major cause of morbidity and mortality in horses. Lactate, specifically the L isomer, is commonly used as a biomarker in colic evaluations. Although L-lactate is currently the most reliable marker for intestinal ischemia, further exploration of other biomarkers may improve outcomes for horses suffering from severe colic.
Article
Medicine, Research & Experimental
Mohamed Abdellah Ibrahim, Walaa Yehia Abdelzaher, Yasmine F. Ibrahim, Amira F. Ahmed, Nermeen N. Welson, Sarah Al-Rashed, Gaber El-Saber Batiha, Asmaa Mohamed Abdel-Aziz
Summary: The study demonstrated that diacerein pretreatment can reduce liver enzyme levels, oxidative stress, and hepatic inflammation by down-regulating the TLR4/NF kappa-B signaling pathway to restore the damaging effects of liver I/R. This hepatoprotective effect is attributed to the antioxidant and anti-inflammatory properties of diacerein, highlighting its potential as a therapeutic agent for liver I/R injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ali Raza Jahejo, Sayyad Ali Raza Bukhari, Nasir Rajput, Nazeer Hussain Kalhoro, Imdad Hussain Leghari, Sayed Haidar Abbas Raza, Zhen Li, Wen-zhong Liu, Wen-xia Tian
Summary: By injecting Ex-FABP protein into TD chickens, this study found that immunity and angiogenesis-related genes play a significant role in the apoptosis of chondrocytes and vascularization in the tibial growth plate.
Article
Nutrition & Dietetics
Finn Jung, Katharina Burger, Raphaela Staltner, Annette Brandt, Sebastian Mueller, Ina Bergheim
Summary: The study showed that markers of liver damage and intestinal barrier function improved significantly in ALD patients after one week of alcohol withdrawal, although not reaching the level of controls.
Article
Biochemistry & Molecular Biology
Yu-Qiong Lei, Yan-Tong Wan, Guang-Tao Liang, Yu-hao Huang, Peng Dong, Si-dan Luo, Wen-juan Zhang, Wei-Feng Liu, Ke-Xuan Liu, Xi-Yang Zhang
Summary: This study evaluated the effects of extracellular RNAs/TLR3 signaling in intestinal I/R injury. The results showed that extracellular RNAs, especially double-stranded RNAs, were significantly increased and TLR3 knockout attenuated intestinal I/R injury. The extracellular RNAs/TLR3 signaling is a key mechanism that regulates intestinal I/R injury in adult mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Dicky L. Tahapary, Atikah I. Fatya, Farid Kurniawan, Cicilia Marcella, Ikhwan Rinaldi, Tri J. E. Tarigan, Dante S. Harbuwono, Em Yunir, Pradana Soewondo, Dyah Purnamasari
Summary: This study aimed to investigate the association of intestinal permeability, measured by levels of intestinal fatty acid-binding protein (I-FABP), with obesity-related type 2 diabetes mellitus (T2DM) in Indonesia. The results showed that the level of I-FABP was higher in the T2DM group compared to the non-T2DM group, and this association was independent of age. The linear regression model indicated a positive correlation between I-FABP and T2DM.
Article
Medicine, General & Internal
Katarzyna Kononczuk, Eryk Latoch, Beata Zelazowska-Rutkowska, Maryna Krawczuk-Rybak, Katarzyna Muszynska-Roslan
Summary: The study reveals a correlation between serum A-FABP and E-FABP levels with overweight and components of metabolic syndrome in acute lymphoblastic leukemia survivors. Survivors with higher BMI and multiple metabolic risk factors showed elevated levels of A-FABP and E-FABP, suggesting their potential involvement in the pathogenesis of obesity and metabolic syndrome in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Tao Han Lee, Cheng-Chia Lee, Jia-Jin Chen, Pei-Chun Fan, Yi-Ran Tu, Chieh-Li Yen, George Kuo, Shao-Wei Chen, Feng-Chun Tsai, Chih-Hsiang Chang
Summary: Urinary liver-type fatty acid binding protein (L-FABP) shows promising performance in predicting postoperative acute kidney injury (AKI) after cardiovascular surgery, especially at 16 to 18 hours postoperatively. Evaluating CPB duration first and then examining urinary L-FABP can improve the accuracy and effectiveness in predicting postoperative AKI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yi Zeng, Fan Yang, Xiaoyan Hu, Fei Zhu, Weixia Chen, Wei Lin
Summary: This study aimed to identify the CT-based predictive factors of Transmural intestinal necrosis (TIN) in patients with acute mesenteric ischemia (AMI). Eleven studies were considered, and the meta-analysis showed that bowel wall thinning, decreased or absent bowel wall enhancement, bowel dilation, pneumatosis intestinalis, porto-mesenteric venous gas, and arterial occlusive AMI were risk factors for predicting TIN. Bowel wall thinning and porto-mesenteric venous gas displayed high specificity to diagnose TIN.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemical Research Methods
Shuvashis Dey, Kevin M. Koo, Emtiaz Ahmed, Matt Trau
Summary: The analysis of secreted protein biomarkers through a nanophotonic immunoarray sensor enables high-throughput, sensitive, and portable detection of sPD-L1. The sensor offers advantages such as surface-enhanced Raman scattering analysis, improved sensitivity compared to ELISA, and compatibility with handheld detection. The performance evaluation demonstrated successful quantitative detection of sPD-L1 in contrived human plasma samples.