Review
Medicine, Research & Experimental
Danqi Li, Yuchen Lou, Yamin Zhang, Si Liu, Jun Li, Juan Tao
Summary: Human immunoglobulin G (IgG), especially sialylated IgG, plays a crucial role in the diagnosis and management of autoimmune diseases by exerting significant anti-inflammatory effects. Current research indicates that IgG Fc N-glycosylations are more reliable diagnostic and monitoring biomarkers than total IgG autoantibodies. IgG sialylation-based therapies show promise in attenuating pathogenic autoimmunity in preclinical and clinical studies.
Article
Multidisciplinary Sciences
Rukmani Lekhraj, Shirin Lalezari, Jennifer T. Aguilan, Jiyue Qin, Simone Sidoli, Wenzhu Mowrey, Seema Gollamudi, Parviz Lalezari
Summary: This study found significantly higher levels of IgM and IgG in the frontal cortex gray matter of late-stage Alzheimer's disease (AD) patients. Levels of IgG2 and IgG4 constant region fragments were also elevated in late-stage AD, while the concentration of native-state IgG4 increased in AD III and VI. Possible involvement of peripheral or meningeal B-cells was suggested, as RNA analysis did not support parenchymal B-cell production of IgG4 in AD III and V.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Jian Lynn Lee, Noraida Mohamed Shah, Mohd Makmor-Bakry, Farida Islahudin, Hamidah Alias, Shamin Mohd Saffian
Summary: The translation reveals that there have been seven popPK studies on IgG, with weight being the only significant covariate across all studies. Future research linking pharmacokinetics with pharmacodynamics in PID and other patient populations is needed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Mourad Kourie, Darko Bogdanovic, Kamran Mahmutyazicioglu, Sam Ghazi, Nikola Panic, Eva Fjellgren, Laila Hellkvist, Tomas Thiel, Anders Kjellman, Nikolaos Kartalis, Olof Danielsson, Lara Dani, J. -Matthias Lohr, Miroslav Vujasinovic
Summary: Immunoglobulin G4-related disease is an immune-mediated condition that can affect various organs. This article reports a case of autoimmune pancreatitis with involvement of the testicles and nasal cavity, which is a rare occurrence. Creating awareness of this rare clinical condition is important due to the availability of highly effective treatments with corticosteroids and rituximab.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Hanna Haberstroh, Aleksandra Hirsch, Sigune Goldacker, Norbert Zessack, Klaus Warnatz, Bodo Grimbacher, Ulrich Salzer
Summary: The purpose of this study was to assess the suitability of measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry as a remote monitoring method for patients with primary immunodeficiencies (PID). The results showed that IgG levels measured from DBS samples were lower than those measured in serum, but there was a high degree of correlation between the two.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Guan-Zhou Zhou, Jia-Qi Zeng, Lei Wang, Miao Liu, Ke Meng, Zi-Kai Wang, Xiu-Li Zhang, Li-Hua Peng, Bin Yan, Fei Pan
Summary: This study compared the clinical features, treatment efficacy, and outcome of autoimmune pancreatitis (AIP) based on serum IgG4 levels and analyzed predictors of relapse. The study found that AIP patients with high IgG4 levels have a more active immune system and a higher relapse rate.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo
Summary: Research has found that interferon-alpha (IFN-alpha) and interleukin-33 (IL-33) serve as potential biomarkers for the diagnosis and monitoring of autoimmune pancreatitis (AIP) and immunoglobulin G4-related disease (IgG4-RD) activity after successful induction of remission. These biomarkers play a crucial role in identifying and treating these autoimmune disorders.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Xian-Da Zhang, Yao Zhang, Yi-Zhou Zhao, Chun-Hua Zhou, Duo-Wu Zou
Summary: Over the past two decades, research on autoimmune pancreatitis (AIP) has rapidly evolved. Japan emerged as the leading country in AIP research, with specialized journals being the primary publication platform for research output. Diagnosis was the main focus, while long-term outcomes and pancreatic tissue acquisition were identified as future research frontiers for AIP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yang Li, Hanyi Song, Xiangzhen Meng, Runzhuo Li, Patrick S. C. Leung, M. Eric Gershwin, Shucheng Zhang, Siyu Sun, Junmin Song
Summary: Autoimmune pancreatitis (AIP) is a rare fibro-inflammatory disorder caused by autoimmune/inflammatory reactions. There are two subtypes of AIP (AIP-1 and AIP-2) with distinct clinical and histologic features. AIP-2 is a pancreas-restricted disease without a specific serum marker, making evaluation of histologic features crucial for diagnosis. Treatment with glucocorticoids or anti-tumor necrosis factor-alpha antibodies shows promise for AIP-2 patients.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Dermatology
Victoria P. Werth, Donna A. Culton, Josef S. S. Concha, James S. Graydon, Laurence J. Blumberg, Joyce Okawa, Michal Pyzik, Richard S. Blumberg, Russell P. Hall
Summary: ALXN1830 treatment in pemphigus showed rapid and significant improvement in disease area index scores, accompanied by reductions in certain blood markers, demonstrating notable efficacy and good tolerability.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Renata Asfor Rocha Carvalho Martins, Fabio Wildson Gurgel Costa, Sara Maria Silva, Paulo Goberlanio de Barros Silva, Francisco Samuel Rodrigues Carvalho, Cristiane Sa Roriz Fonteles, Thyciana Rodrigues Ribeiro
Summary: The salivary levels of immunoglobulins in patients with type 1 diabetes mellitus were compared to healthy controls, showing a decrease in salivary flow and an increase in IgA concentration, though IgG levels did not significantly change. The increase in IgA concentration in saliva was dependent on total protein estimation.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Immunology
Maria Giovanna Danieli, Jacopo Umberto Verga, Cristina Mezzanotte, Irene Terrenato, Silvia Svegliati, Maria Beatrice Bilo, Gianluca Moroncini
Summary: This study aimed to evaluate the anti-inflammatory and immunomodulatory effects of 20% SCIg treatment in patients with polymyositis and dermatomyositis (PM/DM). The results showed significant improvements in muscle strength, creatine kinase levels, skin conditions, dysphagia, disease activity, and disability in PM/DM patients after long-term SCIg therapy. No systemic reactions were reported, and the reported local reactions were transient. The study also found positive outcomes in CVID patients treated with 20% SCIg therapy. Overall, SCIg treatment was found to be a safe and effective alternative to IVIg for PM/DM patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
You Li, Li Yan, Rui Wang, Qixia Wang, Zhengrui You, Bo Li, Jun Zhang, Bingyuan Huang, Yong Chen, Yikang Li, Min Lian, Ruqi Tang, Dekai Qiu, M. Eric Gershwin, Xiao Xiao, Qi Miao, Xiong Ma
Summary: Lower serum IgG levels and less fibrosis in liver histology at diagnosis are associated with better biochemical and histological remission outcomes in autoimmune hepatitis patients. After 3 years of treatment, 69.4% of patients achieved histological remission, with those achieving histological remission showing higher rates of fibrosis regression. Early diagnosis and rapid response to immunosuppressive therapy are important for achieving remission in autoimmune hepatitis.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Review
Immunology
Tomoe Yoshikawa, Tomohiro Watanabe, Ken Kamata, Akane Hara, Kosuke Minaga, Masatoshi Kudo
Summary: Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disorder of the pancreas, often associated with systemic IgG4-related disease (IgG4-RD); the activation of M2 macrophages and plasmacytoid dendritic cells (pDCs) plays a crucial role in the development of AIP and IgG4-RD; recent studies suggest a link between alterations in gut microbiota composition and the development of AIP and IgG4-RD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Cesar Picado, Inaki Ortiz de Landazuri, Alexandru Vlagea, Irina Bobolea, Ebymar Arismendi, Rosanel Amaro, Jacobo Sellares, Joan Bartra, Raimon Sanmarti, Jose Hernandez-Rodriguez, Jose-Manuel Mascaro, Jordi Colmenero, Eva C. Vaquero, Mariona Pascal
Summary: This study highlights the clinical manifestations of Selective IgE deficiency (SIgED), which include various infectious diseases, autoimmune conditions, eczematous dermatitis, and malignancies. Patients with SIgED have an increased risk of developing malignancies, warranting further prospective studies to better characterize this condition and determine its inclusion in the list of antibody deficiencies.
JOURNAL OF CLINICAL MEDICINE
(2021)