Journal
JOURNAL OF FORENSIC SCIENCES
Volume 56, Issue 2, Pages 415-417Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1556-4029.2010.01670.x
Keywords
forensic sciences; sudden infant death syndrome; TH01 polymorphism; forensic genetics; catecholamine forensic pathology; tyrosine hydroxylase; genotyping
Categories
Ask authors/readers for more resources
Sudden infant death syndrome (SIDS) constitutes a considerable percentage of infant death of unknown etiology. Individual catecholamine response variation is suspected to play a role in SIDS. TH01 is a tetrameric short tandem repeat marker in the tyrosine hydroxylase gene, which regulates gene expression and catecholamine production with allele 9.3 exerting a particularly strong effect on noradrenalin production. We investigated in an age-controlled study the TH01 allele frequencies in 127 cases of SIDS and 406 control cases to assess whether in SIDS cases a distinct TH01 allele distribution could be determined as has been reported by a previous study. We found that genotypes containing one or two 9.3 alleles were significantly more frequent in SIDS patients (58.2%) than in control subjects (48.4%, p = 0.038), whereas all other alleles were more frequent in the control subjects. Our findings support the notion that there exists a significant association between TH01 gene configuration and SIDS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available