Review
Engineering, Biomedical
Benjamin Dalisson, Baptiste Charbonnier, Ahmed Aoude, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: This review article discusses different strategies for repairing massive segmental bone defects and explores emerging potential replacements for the standard treatment of fibular transplantation with a blood supply. The review highlights the importance of considering more basic approaches in bone repair and challenges the assumption that mimicry is necessary for success in repair strategies.
ACTA BIOMATERIALIA
(2021)
Article
Orthopedics
Won Chul Shin, Jae Hoon Jang, Nam Hoon Moon, Se Bin Jun
Summary: This study aimed to compare the radiological results between closed nailing without bone graft and open nailing with bone graft for aseptic subtrochanteric nonunion. The results showed that closed nailing without bone graft was as effective as open nailing with bone graft, suggesting that closed procedure without bone graft may be a suitable option for selected patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Medicine, General & Internal
Kenneth P. Powell, Ahmed Hammouda, Larysa P. Hlukha, Jessica C. Rivera, Minoo Patel, S. Robert Rozbruch, Janet D. Conway, John E. Herzenberg
Summary: This study aimed to investigate the bone healing outcomes and complications of lower limb lengthening in older patients (>= 60 years) using magnetic intramedullary lengthening nail (MILN). The results showed no significant difference in healing parameters and complications between the older population and the general adult population, suggesting that MILN may be a safe and feasible option for limb lengthening in generally healthy elderly individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Erik J. Geiger, Adam D. Geffner, S. Robert Rozbruch, Austin T. Fragomen
Summary: Traditionally, critical-sized bone defects in the tibia have been treated using circular external fixators. A recent development in this area is the use of an all-internal bone transport nail for tibia reconstruction, which avoids the complications associated with chronic external fixation. However, there is limited research on the outcomes of using this implant for bone reconstruction.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Orthopedics
Jie Fang, Rongjian Shi, Weiya Qi, Dawei Zheng, Hui Zhu
Summary: The feasibility and clinical outcomes of using the induced membrane technique and autologous structural bone grafting for treatment of phalangeal and metacarpal segmental defects were evaluated. Results showed union of all bone grafts, good wound healing without infection complications, and satisfactory finger motion.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Materials Science, Multidisciplinary
Ricard Aceves-Argemi, Elisabet Roca-Millan, Beatriz Gonzalez-Navarro, Antonio Mari-Roig, Eugenio Velasco-Ortega, Jose Lopez-Lopez
Summary: This systematic review analyzed the use of titanium meshes in bone regeneration, showing an average bone gain of 4.3 mm, high survival and success rates of implants, but a significant risk of mesh exposure.
Article
Biotechnology & Applied Microbiology
Weihang Gao, Ke Zhao, Yuanyuan Guo, Mao Xie, Xiaobo Feng, Ping Liu, Xin Xie, Dehao Fu
Summary: The study aimed to compare the biomechanical stability of three internal fixation strategies for extra-articular comminuted proximal tibial fractures: single lateral plating, double plating, and intramedullary nailing. The results showed that the use of additional proximal interlocking screws significantly improved the biomechanical stability of intramedullary nailing, while the use of an additional medial plate improved the torsional stability of double plating.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Holger Freischmidt, Jonas Armbruster, Emma Bonner, Thorsten Guehring, Dennis Nurjadi, Maren Bechberger, Robert Sonntag, Gerhard Schmidmaier, Paul Alfred Gruetzner, Lars Helbig
Summary: Non-unions present a challenge to trauma surgeons due to limited treatment options, long duration, and unsatisfactory outcomes. Alternative therapeutic strategies are desirable to improve outcomes. This study shows that bone graft substitutes have osteoinductive and osteoconductive effects, while systemic PTH administration can induce vascularization, potentially serving as a synergistic co-treatment with bone graft substitutes.
Article
Biotechnology & Applied Microbiology
Shaowei Zheng, Haobo Zhong, Hao Cheng, Xu Li, Guowei Zeng, Tianyu Chen, Yucong Zou, Weile Liu, Chunhan Sun
Summary: In this study, a TEOS-hydrogel was designed with self-healing property, low swelling rate, degradability, and good biocompatibility, and capable of inducing osteogenic differentiation of bone marrow mesenchymal stem cells. In rabbit models, the TEOS-containing hydrogel accelerated bone regeneration, demonstrating its potential for treating critical-size segmental bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Morshed Khandaker, Reuben Lane, Shannon Yeakley, Hussein Alizereej, Sadegh Nikfarjam, Abdellah Ait Moussa, Melville B. Vaughan, Amgad M. Haleem
Summary: In this study, a scaffold and fixation system for the reconstruction of long-bone segmental defects in a rabbit tibia model were designed and manufactured. Biocompatible and biodegradable materials, polycaprolactone (PCL) and PCL soaked with sodium alginate (PCL-Alg), were used to manufacture the scaffold, interlocking nail, and screws. Degradation and mechanical tests showed that both PCL and PCL-Alg scaffolds were suitable for faster degradation and early weight-bearing capacity. A surgical jig was designed and 3D-printed using biocompatible resin to ensure accurate placement of the scaffold and fixation system. Cadaver tests confirmed the potential of the designed jigs, nails, and screws for future reconstructive surgeries.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Biomaterials
Miao Sun, Huifeng Shao, Haibin Xu, Xiaofu Yang, Mingyi Dong, Jiaxing Gong, Mengfei Yu, Zhongru Gou, Yong He, An Liu, Huiming Wang
Summary: A novel device consisting of biodegradable intramedullary nails made with bioceramics has been reported for the first time, showing high bending strength and stable structure. These nails can fix and support fracture models, promote osteogenesis, and potentially replace traditional metal intramedullary nails as a more effective treatment option for tibial fractures.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Cell & Tissue Engineering
Yongfeng Li, Huawei Liu, Chao Wang, Rongzeng Yan, Lei Xiang, Xiaodan Mu, Lingling Zheng, Changkui Liu, Min Hu
Summary: This study aimed to fabricate 3D-printing titanium grid scaffolds to achieve bone fusion in mandibular segmental defects. The results showed that the scaffolds with sufficient pores and basic biomechanical strength could facilitate bone regeneration and integration of bone broken ends. Clinical observations on both animal models and patients confirmed the successful bone regeneration in mandibular defects using the titanium grid scaffolds.
NPJ REGENERATIVE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yiwei Li, Chun Xu, Chang Lei
Summary: Bone regeneration is a complex process involving different stages, and growth factors (GFs) are essential for this process. Nanomaterials have emerged as promising vehicles for delivering GFs, as they can protect and control the release of GFs, as well as activate endogenous GFs to modulate the regeneration process.
Article
Clinical Neurology
Arjan C. Y. Loenen, Marloes J. M. Peters, Raymond T. J. Bevers, Claus Schaffrath, Els van Haver, Vincent M. J. Cuijpers, Timo Rademakers, Bert van Rietbergen, Paul C. Willems, Jacobus J. Arts
Summary: This study compared bone ingrowth and segmental stability of lumbar interbody fusion using two different cage types in a preclinical ovine model. The results showed that the newly developed trussed titanium (TT) cages had more direct bone to implant contact and exhibited a more gradual increase in stability compared to conventional polyether ether ketone (PEEK) cages, which had higher bone volume over total volume.
Review
Orthopedics
Jian Li, Xiuyu Qin, Jiani Wang, Wangzhe Yang, Junjun Bai, Jia Lv
Summary: This study compared the clinical efficacy and surgical safety of three commonly used bone implant methods for spinal tuberculosis through network meta-analysis. The results indicated that autogenous granular bone graft (AG) might be the optional treatment with good surgical safety. Moreover, titanium mesh bone graft (TM) can significantly reduce the loss of Cobb angle and shorten bone graft fusion time.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
