Article
Food Science & Technology
Jaeeun Jung, Jeongjin Park, Minhee Lee, Jinhak Kim, Dongchan Oh, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: In this study, the potential anti-obesity effects of Salacia reticulata extracts (SC) were explored in obese mice and 3T3-L1 adipocytes, revealing that SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size. SC treatment also exerted inhibitory effects on adipogenesis and lipogenesis, while promoting lipolysis and thermogenesis pathways. These findings suggest that SC has a direct influence on lipid metabolism of adipocytes, making it a promising candidate for weight loss interventions.
Article
Chemistry, Multidisciplinary
Vipul V. Betkekar, Keisuke Suzuki, Ken Ohmori
Summary: The first total synthesis of parameritannin A2, a branched epicatechin tetramer, was achieved by overcoming synthetic challenges using the phloroglucinol trick. This method allowed the single-step assembly of two EC units and the successful construction of the desired structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, Research & Experimental
Sudhakara Gujjala, Manjunatha Bangeppagari, Venkata Lakshmi Narasimha Prasad Devarakonda, Ramesh Bellamkonda, Ramu Bhadramraju, Srinivasan Kameswaran, Rajendran Ramaswamy, Saralakumari Desireddy
Summary: This study explored the effects of Salacia reticulata and simvastatin on oxidative stress and insulin resistance in rats. The researchers found that treatment with Salacia reticulata or simvastatin significantly reduced the negative effects of a high-fat diet on lipid levels, lipid peroxidation, and protein oxidation. In addition, Salacia reticulata showed greater efficacy in preventing liver inflammation and fibrosis in high-fat diet fed rats. These findings suggest that Salacia reticulata and simvastatin may be promising remedies for obesity and related metabolic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Lujing Xu, Songbai Liu
Summary: Novel tea polyphenolic-copper hybrid nanoflowers were assembled in this study, showing faster growth rates compared to protein-based nanoflowers. The framework of the nanoflowers was composed of tea polyphenolic oligomers and copper phosphate crystals, providing high loading capacity for curcumin and protection from UV irradiation and thermal treatment. The controlled release of the nanoflowers could be achieved by adjusting pH conditions, making tea polyphenols a promising organic component for nanoflower generation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Galbada Arachchige Sirimal Premakumara, Walimuni Kanchana Subhashini Mendis Abeysekera
Summary: Salacia reticulata possesses anti-protein-glycation, glycation-reversing, and free radical scavenging activities. Besides root and stem, leaves and twigs may also be useful sources of anti-diabetic bioactive molecules.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Chemistry, Applied
Rui Cui, Shengnan Ji, Minquan Xia, Xing Fu, Xi Huang
Summary: This study investigated the effects of polyphenols on the trypsin inhibitory activity (TIA) of ovomucoid (OVM) in eggs. The results showed that epigallocatechin gallate (EGCG) and gallic acid (GA) individually reduced TIA by 62.34% and 90.41% respectively. Both EGCG and GA interacted with OVM through static quenching and hydrophobic interaction, causing a conformational transition in OVM from disorder to order.
Article
Chemistry, Medicinal
Gyeong Han Jeong, Jae-Hyeon Cho, Kwang-Il Park, Kyungho Kim, Tae Hoon Kim
Summary: This study demonstrates a rapid and simple enzymatic transformation of the coumarin esculetin using polyphenol oxidase derived from Agaricus bisporus. Five new oxidized metabolites, esculetinins A-E, were produced along with a known compound isoeuphorbetin. The esculetin oligomers 2 and 3 showed significantly enhanced inhibitory activities against α-glucosidase with competitive modes of action.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Ines Paccetti-Alves, Marta S. P. Batista, Catarina Pimpao, Bruno L. Victor, Graca Soveral
Summary: The natural polyphenolic compound Rottlerin (RoT) has shown potential as an anticancer agent by inhibiting target molecules implicated in tumorigenesis. It has been found to inhibit human AQP3 activity with an IC50 in the micromolar range. Molecular docking and simulations have revealed the structural determinants of RoT that explain its ability to inhibit AQP3. This multidisciplinary approach provides new information for aquaporin research and future drug design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yuan Ma, Ping Liu, Ai-lian Meng, Lin Deng, Wei Xue, Fang Chen, Zhen-ming Che
Summary: This study compared the biochemical properties of membrane-bound polyphenol oxidase (mPPO) and soluble polyphenol oxidase (sPPO) in Prunus mume. The findings showed that sPPO had a greater affinity for the substrate catechol, while mPPO had higher activity with catechol and 4methylcatechol. The optimal pH for sPPO was 5.0, while mPPO had optimal pH values of 4.5 and 5.5. The temperatures that yielded the highest activity for sPPO and mPPO were 40 degrees C and 60 degrees C, respectively. sPPO was more resistant to acidic environments, while mPPO demonstrated better stability with temperature changes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Roland Tolulope Loto, Temitayo Ikuerowo, Sophia Ifezue
Summary: The corrosion inhibition performance of Pelargonium and Citrus reticulata oil concentrates and their admixture on carbon steel in different media was studied using various techniques. The results showed that Citrus reticulata oil performed well in HCl solution, while Pelargonium oil was effective in H2SO4 solution. The admixture showed enhanced corrosion inhibition performance in HCl solution.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Biochemistry & Molecular Biology
Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova, Volodymyr V. Shvadchak
Summary: Parkinson's disease is characterized by the death of certain neurons in the midbrain and the accumulation of alpha-synuclein fibrils. Current treatment involves increasing dopamine levels, but this can produce toxic oligomers. In our study, we found that these oligomers can inhibit alpha-synuclein fibrillization, providing insights into the effects of dopamine-enhancing therapy on Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Xueli Wang, Chengke Wang, Hei-Nga Chan, Iyaswamy Ashok, Senthil Kumar Krishnamoorthi, Min Li, Hung-Wing Li, Man Shing Wong
Summary: Novel near infrared emissive fluorophores exhibit strong selectivity towards Aβ oligomers and monomers, good biocompatibility and stability, and significant inhibitory effects on Aβ aggregation.
Article
Materials Science, Multidisciplinary
Yongji He, Ning Li, Zuojia Xiang, Youjie Rong, Lisheng Zhu, Xiaobo Huang
Summary: This study designed natural polyphenol compounds as radical inhibitors in photosensitive gel inks, which showed excellent anti-polymerization effect and could prevent gelation in non-printing conditions, ensuring the success of 3D printing.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Qing Xiang, Jiahong He
Summary: This study investigated the corrosion inhibition properties of natural plant extract CRLE on copper in sulfuric acid environment using theoretical and experimental methods. The experimental results demonstrated that CRLE can form a stable barrier film on the copper surface, showing excellent corrosion inhibition efficiency. Additionally, surface topography analysis and adsorption isotherm model studies supported the electrochemical experimental results, indicating that CRLE adheres to the copper interface in a Langmuir monolayer adsorption manner.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Medicinal
Toshio Morikawa, Kiyofumi Ninomiya, Genzoh Tanabe, Hisashi Matsuda, Masayuki Yoshikawa, Osamu Muraoka
Summary: Studies have shown that active components isolated from plants in the Salacia genus have anti-diabetic effects, traditionally used in Ayurvedic medicine for early-stage diabetes treatment and widely consumed as a food supplement for obesity and diabetes prevention worldwide.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Yun-Qiu Li, Masako Kitaoka, Juri Takayoshi, Ya-Feng Wang, Yosuke Matsuo, Yoshinori Saito, Yong-Lin Huang, Dian-Peng Li, Gen-ichiro Nonaka, Zhi-Hong Jiang, Takashi Tanaka
Summary: This study isolated and characterized new hydrolyzable tannins from Polygonaceous plants, including a new compound named persicarianin; it also identified other types of hydrolyzable tannins. The results suggest that some Polygonaceous plants are a potential source of both proanthocyanidins and hydrolyzable tannins.
Article
Chemistry, Multidisciplinary
Takako Yamashita, Yosuke Matsuo, Yoshinori Saito, Takashi Tanaka
Summary: Through investigation of CuCl2-mediated oxidation reactions in an aqueous medium, it was found that in the biosynthesis of ellagitannins, DHHDP is the initial product of the oxidative coupling of two galloyl groups, and subsequent reductive metabolism forms HHDP esters.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Juri Takayoshi, Yong-Lin Huang, Yosuke Matsuo, Yoshinori Saito, Dian-Peng Li, Takashi Tanaka
Summary: Ellagitannins (ETs) are plant polyphenols with health benefits. Insect tea from Guangxi region contains ET metabolites produced in the digestive tract of moth larvae and may have higher bioavailability than original ETs.
Article
Chemistry, Applied
Takashi Tanaka, Miho Yasumatsu, Mayu Hirotani, Yosuke Matsuo, Na Li, Hong-Tao Zhu, Yoshinori Saito, Kanji Ishimaru, Ying-Jun Zhang
Summary: This study investigated the reaction of Theanaphthoquinone (TNQ) with epigallocatechin-3-O-gallate (EGCg) in black tea leaves, revealing the formation of novel reaction products and providing new insights into the formation of black tea pigment thearubigins.
Article
Chemistry, Medicinal
Yiming Hu, Yoshinori Saito, Xun Gong, Yosuke Matsuo, Takashi Tanaka
Summary: Seven new compounds were isolated from the roots of Eupatorium heterophyllum, along with 2 new compounds. Spectroscopic techniques were used for characterization. The chemical diversity in the roots was found to be lower than in the aerial parts.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Yiming Hu, Yoshinori Saito, Yosuke Matsuo, Xun Gong, Takashi Tanaka
Summary: Two novel epimers of benzofuran dimers (1 and 2), along with their monomeric precursor, were isolated from the roots of Eupatorium heterophyllum. The structures and configurations of the dimers were determined using NMR, HRFABMS, and DFT calculations. The absolute configurations were confirmed using TDDFT calculations of the ECD spectra.
TETRAHEDRON LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Zhang-Bin Liu, Yosuke Matsuo, Yoshinori Saito, Yong-Lin Huang, Dian-Peng Li, Takashi Tanaka
Summary: The identification of unstable metabolites of ellagitannins with ortho-quinone structures or reactive carbonyl groups is crucial for understanding their biosynthesis and degradation. The degradation of vescalagin, a major ellagitannin in oak young leaves, involves regioselective oxidation to produce a putative quinone intermediate, which has not been identified yet. In this study, phenazine derivatives of the elusive quinone intermediate were obtained from the extraction of young leaves of Quercus dentata, using 80% acetonitrile containing 1,2-phenylenediamine to trap the unstable ortho-quinone metabolites. Additionally, phenylenediamine adducts of liquidambin and dehydroascorbic acid were also obtained, providing insights into the biosynthesis of C-glycosidic ellagitannins in oak leaves.
Article
Biochemistry & Molecular Biology
Yiming Hu, Yoshinori Saito, Yosuke Matsuo, Xun Gong, Takashi Tanaka
Summary: This study investigated the chemical constituents of two root samples of Eupatorium heterophyllum DC. collected in Yunnan Province, China. New benzofurans and derivatives were isolated, and their structures were determined. It is the first time that oligomeric benzofurans have been found in this plant, indicating the ongoing diversification of secondary metabolites in E. heterophyllum.
Article
Agriculture, Multidisciplinary
Keigo Hashiguchi, Sena Teramoto, Kohei Katayama, Yosuke Matsuo, Yoshinori Saito, Takashi Tanaka
Summary: Thearubigins (TRs) are chemically ill-defined black tea pigments composed of numerous catechin oxidation products. The oligomerization mechanisms of TRs are poorly understood, but it was found that the A-ring methine carbons of catechins participate in the oligomerization process. Inter-molecular oxidative couplings between the B-rings and A-rings of pyrogallol-type catechins are involved in the oligomerization, which is important in the production of TRs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yiming Hu, Yoshinori Saito, Yasuko Okamoto, Yosuke Matsuo, Xun Gong, Takashi Tanaka
Summary: In this study, eight samples of Eupatorium heterophyllum leaves were collected from different locations in Yunnan and Sichuan provinces in China, and their chemical constituents were investigated. Thirteen previously undescribed sesquiterpene lactones were isolated and their structures were elucidated. The major constituents varied depending on the location, suggesting the presence of locality-dependent intra-specific diversity in the chemical constituents of E. heterophyllum leaves.