Article
Food Science & Technology
Yu-Ting Zhou, Ya-Ning Xu, Xi-Yun Ren, Xiao-Feng Zhang
Summary: This study found that suppressing microglia-mediated inflammation can alleviate dopaminergic neurodegeneration caused by paraquat in mice with Parkinson's disease, and this mechanism may be related to the improvement of blood-brain barrier function.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Immunology
Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Maria A. Deli, Andrea Kroeger, Thomas Schueler, Ildiko Rita Dunay
Summary: Our study demonstrates that T. gondii initially infects endothelial cells in the choroid plexus, triggering early local immune responses and barrier disturbances which ultimately affect BCSFB function.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Priscila Anhel Medrano-Gonzalezl, Franklin Cruz-Villegas, Alejandro Alarcon del Carmen, Luis Felipe Montano, Erika Patricia Rendon-Huerta
Summary: Claudin-6 overexpression is associated with an increase in the generation of cancer stem cells and dedifferentiation of epithelial cells in gastric cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Lorena Rosas-Martinez, Rafael Rodriguez-Munoz, Maria del Carmen Namorado-Tonix, Fanis Missirlis, Leonardo del Valle-Mondragon, Alicia Sanchez-Mendoza, Jose L. Reyes-Sanchez, Luz Graciela Cervantes-Perez
Summary: This study aims to investigate the impact of hyperglycemia on renal expression of claudins-2 and -5 in diabetic nephropathy and the role of glucose-induced oxidative stress. The results show that chronic high-glycemia levels in early stages of diabetic nephropathy decrease expression of claudins-2 and -5, increase oxidative stress, and induce MMP-activity faster than chronic middle-glycemia levels. The level of hyperglycemia plays a crucial role in the progression of diabetic nephropathy.
Article
Biochemistry & Molecular Biology
Eun-Hye Kim, Eun-Sun Kim, Donggeun Shin, Donghyun Kim, Sungbin Choi, Young-Jun Shin, Kyeong-A Kim, Dabi Noh, Ahmet B. Caglayan, G. K. Rajanikant, Arshad Majid, Ok-Nam Bae
Summary: The study found that carnosine inhibits MMP activity by chelating zinc, resulting in the reduction of edema and brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Li Yan, Cole W. Dwiggins, Rebecca A. Moriarty, Jae W. Jung, Udit Gupta, Ken D. Brandon, Kimberly M. Stroka
Summary: The blood-brain barrier (BBB) responds to mechanical cues and changes in substrate stiffness. The compromised function of the BBB is associated with neurological disorders and altered brain stiffness. Understanding the effects of matrix stiffness on BBB permeability could lead to new treatments for BBB dysfunction-related diseases.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Shohreh Fakhari, Ali Jalili, Bahram Nikkhoo, Bayazid Ghaderi, Mohammad Amin Boshagh, Sako Mirzaie, Mohammad Moradzad
Summary: This study found that the expression of MT2-MMP is significantly increased in multiple myeloma cells and plays an important role in the growth and progression of these cells. These findings suggest that MT2-MMP may be a potential biomarker for diagnosis and therapeutic interventions of multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Chemistry, Analytical
Wenfei Guo, Xiaonan Gao, Renhui Zhan, Zengteng Zhao, Kehua Xu, Bo Tang
Summary: A tricolor fluorescence nanoprobe based on Au-Se nanoplatform was designed to simultaneously image MMP-2, MMP-7, and MMP-9, investigating tumor cells' invasion and migration behaviors under inflammation. The nanoprobe specifically responds to MMP-2/7/9, allowing visualization in biological systems.
Review
Clinical Neurology
Riccardo Serra, J. Marc Simard
Summary: This article reviews 45 research articles on intercellular junctions in the ependyma, indicating the important role of ependymal lining ultrastructure in fluid flow interactions in the brain. These findings have implications for understanding and treating CSF-related disorders.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Manami Iida, Shuichi Ohtomo, Naoko A. Wada, Otoya Ueda, Yoshinori Tsuboi, Atsuo Kurata, Kou-Ichi Jishage, Naoshi Horiba
Summary: CL-1 is responsible for the paracellular barrier function of glomerular parietal epithelial cells, but its role in proximal tubules is still unclear. Inflammation-induced TNF-alpha can induce CL-1 expression, while albumin has no effect on CL-1 expression.
Article
Cell Biology
Daniel Maucher, Birte Schmidt, Julia Schumann
Summary: Dysfunction of the endothelial barrier is central in inflammatory processes like sepsis and atherosclerosis. In this study, cytokine-induced weakening of the endothelial barrier was associated with changes in the transcriptome and upregulation of miR-29a-3p, miR-29b-3p, and miR-155-5p, which target central adhesion proteins' mRNAs. This suggests a posttranscriptional mechanism regulated by inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Didem Keles, Murat Sipahi, Seniz Inanc-Surer, Mustafa B. A. Djamgoz, Gulgun Oktay
Summary: Tetracaine, a type of long-acting amino ester local anesthetic, can inhibit the invasive characteristics of breast cancer cells by suppressing their migratory, invasive, and adhesive abilities. This effect may be achieved by reducing the expression and activity of MMP-2 and MMP-9, as well as increasing TIMP-2 expression. The anti-invasive effects of tetracaine make it a potential candidate for clinical use in surgery and combination therapies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Viviana Scalavino, Emanuele Piccinno, Antonio Lacalamita, Angela Tafaro, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino
Summary: This study identified 18 dysregulated miRNAs in intestinal epithelial cells from the ulcerative colitis (UC) mice model. MiR-195-5p, one of the down-regulated miRNAs, was found to be involved in impaired barrier function. The study demonstrated that miR-195-5p can regulate tight junctions by decreasing CLDN2 levels and subsequently affecting CLDN1 expression.
Article
Biochemistry & Molecular Biology
Hyesook Lee, Da Hye Kim, Jeong-Hwan Kim, Seh-Kwang Park, Ji-Won Jeong, Mi-Young Kim, Seok-Ho Hong, Kyoung Seob Song, Gi-Young Kim, Jin Won Hyun, Yung Hyun Choi
Summary: UPM induces cytotoxicity and morphological changes in human retinal pigment epithelial cells, leading to cell death and autophagy, while NAC effectively suppresses UPM toxicity. Furthermore, UPM causes DNA damage and mitochondrial dysfunction, which can be restored by NAC.
Article
Biochemistry & Molecular Biology
Seon-Kyu Kim, Seong-Hwan Park, Yeong Uk Kim, Young Joon Byun, Xuan-Mei Piao, Pildu Jeong, Kyeong Kim, Hee Youn Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Sung-Kwon Moon, Yung Hyun Choi, Wun-Jae Kim, Seon-Young Kim, Seok Joong Yun
Summary: A molecular signature, MSP888, has been identified for Non-muscle-invasive bladder cancer (NMIBC) that can predict heterogeneity and responses to Bacillus Calmette-Guerin (BCG) therapy. This signature includes three distinct molecular subtypes, with DP.BCG+ related to progression and response to BCG treatment, and REC.BCG+ related to recurrence and response to BCG treatment. These findings enhance understanding of NMIBC prognosis and the effectiveness of BCG therapy, potentially improving clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyesook Lee, Seon Yeong Ji, Hyun Hwangbo, Min Yeong Kim, Da Hye Kim, Beom Su Park, Joung-Hyun Park, Bae-Jin Lee, Gi-Young Kim, You-Jin Jeon, Yung Hyun Choi
Summary: GABA-enriched salt has a protective effect against renal injury caused by high salt intake in cisplatin-induced nephrotoxicity mice, reducing hematological and biochemical toxicity, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Eunok Im, Yung Hyun Choi, Nam Deuk Kim
Summary: Bile acids are important in lipid digestion and absorption, and have been found to be tumor suppressors. This review comprehensively summarizes the literature on bile acid-induced programmed cell death and the development of synthetic bile acid derivatives for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Ao Xuan Zhen, Herath Mudiyanselage Udari Lakmini Herath, Hee Kyoung Kang, Yung Hyun Choi, Jin Won Hyun
Summary: Hesperidin has the potential to reduce intracellular reactive oxygen species (ROS) generation and oxidative damage, improve cellular autophagy and apoptosis, and therefore, treat PM2.5-induced skin damage.
Article
Biochemistry & Molecular Biology
Yuna Cho, Yun-Jeong Jeong, Kwon-Ho Song, Il-Kyung Chung, Junji Magae, Taeg Kyu Kwon, Yung-Hyun Choi, Jong-Young Kwak, Young-Chae Chang
Summary: 4-O-methylascochlorin (MAC) induces apoptosis and autophagy in cervical cancer cells. MAC promotes cell death by inducing apoptosis and stimulates cell survival by promoting autophagy through the inhibition of Akt, mTOR, and p70S6K phosphorylation. MC-induced apoptosis and autophagy are regulated by BNIP-3. Co-treatment of cells with MAC and chloroquine enhances cell death in cervical cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Seon-Kyu Kim, Young Joon Byun, Chuang-Ming Zheng, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Wun-Jae Kim, Sung-Kwon Moon, Yung Hyun Choi, Seok Joong Yun
Summary: This study compared the utility of different risk assessments in NMIBC patients and found that the molecular signature-based subtype predictor (MSP888) had independent predictive value for NMIBC progression, especially in patients without intravesical BCG immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Seonghui Kim, Duhyeon Kim, Min Young Um, Minseok Yoon, Jae-Suk Choi, Yung Hyun Choi, Suengmok Cho
Summary: Insomnia is a common sleep disorder and natural sleep aids are gaining popularity as alternatives to prescription drugs. Recent studies have shown that marine polyphenols, specifically phlorotannins found in brown algae, have sedative-hypnotic effects. These effects are mediated through the gamma-aminobutyric acid type A-benzodiazepine receptor. The supplement containing phlorotannins from Ecklonia cava has been approved for improving sleep quality.
Article
Chemistry, Multidisciplinary
Young Hoon Kwon, Jung Yoon Jang, Jun Ho Lee, Young Whan Choi, Yung Hyun Choi, Nam Deuk Kim
Summary: Loquat leaf extract has a protective effect on myoblasts, inhibiting oxidative damage and apoptosis induced by hydrogen peroxide. It also promotes cellular differentiation and upregulates AMPK, Nrf2, and HO-1 signaling pathways. These findings suggest that loquat leaf extract may be a potential therapeutic candidate for treating myoblast injury and enhancing cellular differentiation.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Jun Ho Lee, Jung Yoon Jang, Young Hoon Kwon, Seung Ho Lee, Cheol Park, Yung Hyun Choi, Nam Deuk Kim
Summary: The effectiveness of rosemary extract (RE) in inducing myotube differentiation and inhibiting AICAR-induced muscle atrophy was evaluated in this study. The results showed that RE increased myotube thickness and promoted the expression of muscle differentiation-related proteins MyoD and myogenin. Furthermore, RE reduced the expression of muscle atrophy-related proteins FoxO3a, MAFbx/atrogin-1, and MuRF-1, while significantly increasing the expression of MyoD and myogenin.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Min Yeong Kim, EunJin Bang, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jeong Sook Noh, Gi-Young Kim, Suengmok Cho, Hyesook Lee, Yung Hyun Choi
Summary: The study found that phloroglucinol can protect human retinal pigment epithelium cells from oxidative damage, reduce apoptosis, and improve cell function by decreasing ROS production.
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Yung Hyun Choi, Joyce H. Lee, Mi-Hwa Lee, Chang-Hee Kang, Chang-Min Lee, Gi-Young Kim
Summary: In this study, the anti-fibrotic effects of derrone on TGF-beta 1-stimulated MRC-5 lung fibroblast cells and bleomycin-induced lung fibrosis were investigated. It was found that high concentrations of derrone increased cytotoxicity in MRC-5 cells, but low concentrations did not induce significant cell death. Derrone reduced the expression of TGF-beta 1, fibronectin, elastin, and collagen1 alpha 1 in TGF-beta 1-stimulated MRC-5 cells, and also attenuated fibrotic histopathological changes in bleomycin-treated mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jieun Kim, Chanbin Lee, Jinsol Han, Hayeong Jeong, Sihyung Wang, Yung Hyun Choi, Youngmi Jung
Summary: Liver fibrosis is primarily caused by activated hepatic stellate cells (HSCs), and targeting these cells is crucial in preventing liver fibrosis. This study investigated the in vivo functions of thymosin beta 4 (T β 4) in liver fibrosis by generating T β 4 conditional knockout mice. The selective deletion of T β 4 in activated HSCs attenuated liver injury and fibrosis by repressing Hedgehog signaling. Re-expression of T β 4 reversed the effect of HSC-specific T β 4 deletion and led to liver fibrosis with Hedgehog activation. These findings suggest T β 4 as a potential therapeutic target for liver fibrosis.
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, Seon Yeong Ji, Da Hye Kim, Min Yeong Kim, EunJin Bang, Su Hyun Hong, Sung Ok Kim, Soon-Jeong Jeong, Hyesook Lee, Sung-Kwon Moon, Jung-Hyun Shim, Gi-Young Kim, Suengmok Cho, Yung Hyun Choi
Summary: Phloroglucinol, a polyphenolic compound, has potent antioxidant activity in mouse myoblasts and may have therapeutic benefits for oxidative-stress-mediated muscle disease by activating Nrf2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
