Review
Medicine, General & Internal
Baraa Nawash, Joshua Ong, Matthew Driban, Jonathan Hwang, Jeffrey Chen, Amrish Selvam, Sashwanthi Mohan, Jay Chhablani
Summary: Optical coherence tomography has greatly advanced the diagnosis and management of neovascular age-related macular degeneration. This review aims to assess the prognostic value of OCT-derived biomarkers. The analysis reveals that retinal fluid has the strongest impact on clinical outcomes, including visual acuity and treatment regimens. Consistent findings regarding these OCT prognostic biomarkers can guide personalized clinical decisions and the integration of OCT with artificial intelligence may further improve nAMD therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Enrico Borrelli, Francesco Bandello, Eric H. Souied, Costanza Barresi, Alexandra Miere, Lea Querques, Riccardo Sacconi, Giuseppe Querques
Summary: New imaging technologies have provided a remarkable opportunity to bridge the gap between histology and clinical findings in neovascular AMD, enhancing our understanding of the disease.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Oncology
Pradeep Kumar Panigrahi
Summary: A 72-year-old male with wet neovascular age related macular degeneration in left eye presented with loss of vision for 1 year. After receiving intravitreal Brolucizumab, there was complete resolution of subretinal fluid and improvement in vision, which was maintained for 3 months with the macula remaining dry.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Biology
Oluchukwu Onwuka, Jackson L. Saddemi, Fatma Sema Akkan Aydogmus, Claudia C. Lasalle, David J. Ramsey
Summary: This study examined the relationship between the interval of monitoring the at-risk eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) and the severity of the disease at diagnosis. The study compared the visual acuity and central macular thickness of patients who were actively receiving anti-VEGF treatment at the time of second eye diagnosis with patients who had discontinued treatment in their first eye. The results showed that the at-risk eyes of patients who had stopped treatment prior to fellow eye conversion were monitored less frequently than those who continued treatment. However, the visual acuity and central macular thickness were similar at the time of fellow eye diagnosis for both groups.
Article
Biochemistry & Molecular Biology
Daniel Rudolf Muth, Mario Damiano Toro, Anahita Bajka, Kamil Jonak, Roman Rieder, Myrtha Magdalena Kohler, Jeanne Martine Gunzinger, Eric H. Souied, Michael Engelbert, K. Bailey Freund, Sandrine Anne Zweifel
Summary: This study investigated the associations and predictive factors between different types of macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naive neovascular age-related macular degeneration (AMD). The findings suggest that subretinal drusenoid deposits (SDDs) are a common characteristic in AMD eyes with treatment-naive MNV, and the predominant drusen type may help predict the type of MNV that will develop.
Article
Ophthalmology
Marco Pellegrini, Federico Bernabei, Andrea Mercanti, Stefano Sebastiani, Enrico Peiretti, Claudio Iovino, Giamberto Casini, Pasquale Loiudice, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: This study evaluated choroidal vascular changes in nAMD patients treated with aflibercept injections, showing significant decreases in choroidal thickness and vascularity after treatment, which were significantly correlated with baseline choroidal vascularity index.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mariano Cozzi, Davide Monteduro, Salvatore Parrulli, Federica Ristoldo, Federico Corvi, Federico Zicarelli, Giovanni Staurenghi, Alessandro Invernizzi
Summary: This study aimed to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) in patients with neovascular age-related macular degeneration (nAMD). The size of the cleft increased with MNV reactivation and decreased after treatment, suggesting it could represent an accumulation of fluid actively exudating from the MNV, serving as a sign of nAMD activity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Oncology
Nazife Asikgarip, Emine Temel, Kemal Ornek
Summary: The study found that in patients with nAMD, the thickness of the GCC in the eyes decreased significantly after intravitreal aflibercept injection, especially at 12 months.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Computer Science, Theory & Methods
Wei Feng, Meihan Duan, Bingjie Wang, Yu Du, Yiran Zhao, Bin Wang, Lin Zhao, Zongyuan Ge, Yuntao Hu
Summary: Optical coherence tomography angiography (OCTA) is a non-invasive diagnostic method commonly used in neovascular age-related macular degeneration (nAMD) to provide a comprehensive view of choroidal neovascularization (CNV). In this study, a deep learning model was developed for automatic segmentation of CNV regions from OCTA images. The model demonstrated satisfactory performance in accurately extracting CNV regions from OCTA images of nAMD patients.
JOURNAL OF BIG DATA
(2023)
Article
Ophthalmology
Huixun Jia, Bing Lu, Zhi Zhao, Yang Yu, Fenghua Wang, Minwen Zhou, Xiaodong Sun
Summary: The characteristics of choroidal neovascularization (CNV) measured by optical coherence tomography angiography (OCTA) can predict the prognosis of neovascular age-related macular degeneration (nAMD) after anti-vascular endothelial growth factor (anti-VEGF) therapy. Type 2 and mixed-type neovascularization are associated with a better response to anti-VEGF therapy.
Article
Ophthalmology
Marco Lupidi, Stefano Schiavon, Alessio Cerquaglia, Daniela Fruttini, Ramkailash Gujar, Alessio Muzi, Tito Fiore, Michele Reibaldi, Jay Chhablani, Carlo Cagini
Summary: In a real-world setting, nAMD patients diagnosed with OCT-A showed meaningful improvements in visual and anatomical parameters during 12 months of treatment, without significant differences with those diagnosed by invasive modalities.
ACTA OPHTHALMOLOGICA
(2022)
Review
Ophthalmology
Isabel Bachmeier, Beatriz G. Armendariz, Siqing Yu, Ralf J. Jaeger, Andreas Ebneter, Carl Glittenberg, Daniel Pauleikhoff, SriniVas R. Sadda, Usha Chakravarthy, Sascha Fauser
Summary: Despite successful antiangiogenic therapy in nAMD, fibrosis in the outer retina causes gradual vision loss. Accurate detection and quantification of fibrosis with reliable end-points and biomarkers are needed for the development of effective drugs. This review provides an overview of imaging modalities and criteria used to characterize fibrosis in nAMD, highlighting the heterogeneity in detection methods and severity scales. Optical coherence tomography (OCT) is recommended as the primary modality for fibrosis evaluation, offering detailed and sensitive characterization compared to other imaging techniques.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Gili Kredi, Matias Iglicki, Nir Gomel, Assaf Hilely, Anat Loewenstein, Zohar Habot-Wilner, Dinah Zur
Summary: This study investigated the prevalence, risk factors, and clinical significance of prechoroidal cleft (PC) in Caucasian neovascular age-related macular degeneration (nAMD) patients. The results showed that PC was found in 15% of the patients and was associated with greater retinal and pigment epithelial detachment (PED) height, as well as the presence of multi-layered PED. Eyes with PC required more anti-VEGF injections. The presence of PC correlated with disease activity, and intensive anti-VEGF suppression can preserve vision.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Irmela Mantel, Agata Mosinska, Ciara Bergin, Maria Sole Polito, Jacopo Guidotti, Stefanos Apostolopoulos, Carlos Ciller, Sandro De Zanet
Summary: The study developed a reliable algorithm using deep-learning for automated identification, localization, and volume measurement of exudative manifestations in neovascular age-related macular degeneration. The algorithm demonstrated good performance with high accuracy and repeatability in detecting and measuring intraretinal fluid, subretinal fluid, and pigment epithelium detachment.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Pasquale Viggiano, Maria Oliva Grassi, Giacomo Boscia, Mariagrazia Pignataro, Giovanni Petruzzella, Enrico Borrelli, Teresa Molfetta, Giovanni Alessio, Francesco Boscia
Summary: The study explores the morphofunctional fluctuations in eyes treated for neovascular AMD when switching from aflibercept or ranibizumab to brolucizumab. The results showed that brolucizumab treatment improved visual function in patients and resulted in choroidal vascular enlargement and resolution of subretinal and intraretinal fluid.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Ashleigh Kernohan, Tara Homer, Hosein Shabaninejad, Anthony J. King, Jemma Hudson, Gordon Fernie, Augusto Azuara-Blanco, Jennifer Burr, John M. Sparrow, David Garway-Heath, Keith Barton, John Norrie, Graeme Maclennan, Luke Vale
Summary: This study compares medical and surgical management strategies for advanced glaucoma and suggests that medication may be more cost-effective over a 2-year time horizon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Obstetrics & Gynecology
Linda Fenocchi, Catherine Best, Helen Mason, Andrew Elders, Suzanne Hagen, Margaret Maxwell
Summary: Pelvic floor muscle training (PFMT) is effective in reducing symptoms of pelvic organ prolapse and decreasing the need for hospital-based treatment. In the long term, PFMT reduces the risk of pelvic floor disorders.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Fiona M. Reid, Lorna Aucott, Cathryn M. A. Glazener, Andrew Elders, Christine Hemming, Kevin G. Cooper, Robert M. Freeman, Anthony R. B. Smith, Suzanne Hagen, Mary Kilonzo, Dwayne Boyers, Graeme MacLennan, John Norrie, Suzanne Breeman
Summary: In this study comparing different surgical methods for treating vaginal wall prolapse, there was no significant difference in outcomes between the use of polypropylene mesh, biological xenografts, and native tissue repair. The use of polypropylene mesh did not lead to increased pain or dyspareunia compared to native tissue repairs.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Correction
Ophthalmology
Alasdair Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Article
Health Care Sciences & Services
Sharon E. Davis, Henry Ssemaganda, Jejo D. Koola, Jialin Mao, Dax Westerman, Theodore Speroff, Usha S. Govindarajulu, Craig R. Ramsay, Art Sedrakyan, Lucila Ohno-Machado, Frederic S. Resnic, Michael E. Matheny
Summary: Validating new algorithms often requires knowing the ground truth for data characteristics, which is inaccessible in real-world data. Therefore, simulation studies using synthetic datasets are essential. We developed a generalizable framework for injecting hierarchical learning effects into a robust data generation process to mimic complex clinical environments.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Medicine, Research & Experimental
Beatriz Goulao, Anne Duncan, Karen Innes, Craig R. Ramsay, Brennan C. Kahan
Summary: The re-randomisation design can improve the efficiency and generalisability of studies within trials (SWATs) in trials with multiple follow-up time points.
Article
Multidisciplinary Sciences
Adnan H. Khan, Sudha Priya Soundara Pandi, Jennifer A. Scott, Aida Sanchez-Bretano, Savannah A. Lynn, J. Arjuna Ratnayaka, Jessica L. Teeling, Andrew J. Lotery
Summary: This article describes a new mouse model that can mimic the features of advanced dry age-related macular degeneration, known as geographic atrophy (GA). The model uses an 810 nm laser to create a retinal lesion with central sparing, simulating the parafoveal atrophy seen in patients with progressive GA. The model demonstrates GA-like pathology over a 24-week period, providing an extended window of opportunity for drug evaluation.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Rachel Mairi Baker, Mohasin Ahmed, Marcello Bertotti, John Cassidy, Rejoice Chipuriro, Emma Clewett, Cam Donaldson, Andrew Elders, Lee Ann Fenge, Julie Fox, Karen Galway, Aideen Gildea, Aileen McGuinness, Jennifer McLean, Sarkis Manoukian, Helen Mason, Antony Morgan, Jill Mulholland, Liam O'Hare, Andrew Paterson, Sam Porter, Jack Rendall, Michael J. Roy, Peter Seaman, Merron Simpson, Artur Steiner, Michael P. Kelly
Summary: This research examines how community-led organisations' (CLOs') use of assets-based approaches can improve health and well-being, and how this can vary in different contexts. Assets-based approaches involve bringing people in communities together to achieve positive change using their own knowledge, skills, and experience. Limited research exists on which approaches lead to specific outcomes and how different contexts can impact success.
Article
Medicine, General & Internal
Paul J. Foster, Denize Atan, Anthony Khawaja, Andrew Lotery, Tom MacGillivray, Christopher G. Owen, Praveen J. Patel, Axel Petzold, Alicja Rudnicka, Zihan Sun, Simon Sheard, Naomi Allen
Summary: This article describes the rationale and methodology of eye and vision assessments in the UK Biobank Repeat Imaging study, which aims to provide biomarkers for neuronal and vascular health in cognitive ageing, mild cognitive impairment, and dementia. The study will collect retinal optical coherence tomography (OCT) and colour fundus photographs from a subset of participants to better understand the association between retinal structures, cognitive function, and brain MRI-derived phenotypes.
Article
Medicine, General & Internal
Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C. M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J. Willem L. Tideman, Ronald B. Melles, Caroline C. W. Klaver, David A. Mackey, Cathy Williams, Helene Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim
Summary: This study aimed to predict the risk of high myopia (HM) through an improved polygenic score (PGS) and test if the PGS is predictive of myopic macular degeneration (MMD) after considering refractive error. The study found that PGS can predict the risk of HM in Europeans, but its predictive ability is weaker in other populations.
Article
Infectious Diseases
Benedikte Olsen Michalsen, Alice X. T. Xu, Sarah L. Alderson, Lars Bjerrum, Jamie Brehaut, Heiner C. Bucher, Janet Clarkson, Eilidh Duncan, Jeremy Grimshaw, Ronny Gunnarsson, Sigurd Hoye, Noah Ivers, Donna M. Lecky, Morten Lindbaek, Carl Llor, Pia Touboul Lundgren, Denise O'connor, Celine Pulcini, Craig Ramsay, Par-Daniel Sundvall, Theo Verheij, Kevin L. Schwartz
Summary: This study surveyed the activities and policies of the Joint Programming Initiative on Antimicrobial Resistance - Primary care Antibiotic Audit and Feedback Network (JPIAMR-PAAN) member countries in antibiotic stewardship efforts. The survey revealed gaps and variations in activities and funding sources. However, most countries have national antibiotic stewardship programs or policies aimed at supporting ongoing antimicrobial stewardship efforts and sustainability. The study concludes that JPIAMR-PAAN will continue to collaborate among its members to create best practice resources and toolkits for antibiotic audit and feedback interventions in primary care settings and identify research priorities.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Multidisciplinary Sciences
Aida Sanchez-Bretano, Eloise Keeling, Jennifer A. Scott, Savannah A. Lynn, Sudha Priya Soundara-Pandi, Sarah L. Macdonald, Tutte Newall, Helen Griffiths, Andrew J. Lotery, J. Arjuna Ratnayaka, Jay E. Self, Helena Lee
Summary: l-DOPA deficiency in developing albino eyes leads to abnormalities in retinal development and visual impairment. However, oral supplementation of human equivalent doses of l-DOPA/Carbidopa during the critical postnatal period can rescue visual function by modulating retinal synaptogenesis and PEDF upregulation, improving retinal morphology and function.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Martin J. Menten, Robbie Holland, Oliver Leingang, Hrvoje Bogunovic, Ahmed M. Hagag, Rebecca Kaye, Sophie Riedl, Ghislaine L. Traber, Osama N. Hassan, Nick Pawlowski, Ben Glocker, Lars G. Fritsche, Hendrik P. N. Scholl, Sobha Sivaprasad, Ursula Schmidt-Erfurth, Daniel Rueckert, Andrew J. Lotery
Summary: This study used deep learning to investigate the individual course of retinal changes caused by healthy aging. By analyzing a large data set of retinal OCT images, a counterfactual generative adversarial network (GAN) was created to generate high-resolution OCT images and longitudinal time series. The results showed that the thickness of the retinal nerve fiber layer, combined ganglion cell layer plus inner plexiform layer, inner nuclear layer to the inner boundary of the retinal pigment epithelium, and retinal pigment epithelium changed with age.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
William G. Mitchell, Augusto Azuara-Blanco, Paul J. Foster, Omar Halawa, Jennifer Burr, Craig R. Ramsay, David Cooper, Claire Cochran, John Norrie, David Friedman, Dolly Chang
Summary: This study assessed the baseline ocular parameters predicting long-term intraocular pressure (IOP) control in patients with primary angle closure (PAC) disease after clear lens extraction (CLE) or laser peripheral iridotomy (LPI). The results showed that CLE was more effective in maintaining good IOP control compared to LPI. Non-Chinese ethnicity, higher baseline IOP, and no prior use of glaucoma drops were associated with worse long-term IOP response.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)