Article
Biochemistry & Molecular Biology
Tiange Li, Han Gong, Biyuan Zhan, Xueying Mao
Summary: Chitosan oligosaccharides (COS) attenuate hepatic steatosis by suppressing lipid synthesis and enhancing fatty acid oxidation. AMP-activated protein kinase (AMPK) is involved in the beneficial effects of COS on hepatic steatosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng
Summary: The present study suggests that Diosgenin (DIO) protects against type II diabetes-associated nonalcoholic fatty liver disease (D-NAFLD) by inhibiting hepatic de novo lipogenesis, improving dyslipidemia, and enhancing mitochondrial function.
Article
Chemistry, Medicinal
Xiaoyue Li, Beibei Zeng, Lu Wen, Yingcai Zhao, Zhaojie Li, Changhu Xue, Tiantian Zhang, Yuming Wang
Summary: This study found that the sea cucumber saponin derivative EA2 has a good lipid-lowering effect, effectively alleviating lipid accumulation and regulating lipid metabolism through multiple mechanisms.
Article
Cell Biology
Bangliang Huang, Xin Xiong, Linlin Zhang, Xiufei Liu, Yuren Wang, Xiaoli Gong, Qian Sang, Yongling Lu, Hua Qu, Hongting Zheng, Yi Zheng
Summary: The study reveals that proteinase activity correlates with the development of nonalcoholic fatty liver disease (NAFLD), with Puromycin-sensitive aminopeptidase (PSA) playing a crucial role in hepatic lipid metabolism through regulating antioxidant stress response and lipid accumulation. PSA may serve as a potential biomarker and therapeutic target for treating NAFLD by suppressing NRF2 ubiquitination and impacting downstream antioxidant enzymes.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Cell Biology
Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang, Tsung- Hsu
Summary: Sp1-regulated PGE2 production activates FAO and TCA cycle in mitochondria, resulting in TMZ resistance in GBM. These findings provide a new strategy to attenuate drug resistance or to re-sensitize recurrent GBM.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nathan Kattapuram, Christine Zhang, Muhammed S. Muyyarikkandy, Chaitra Surugihalli, Vaishna Muralidaran, Tabitha Gregory, Nishanth E. Sunny
Summary: Research indicates that diets rich in fats and carbohydrates exacerbate non-alcoholic fatty liver disease (NAFLD) and cause mitochondrial dysfunction. It is suggested that high-fat and high-carbohydrate diets may affect mitochondrial oxidative remodeling differently. The high fructose-driven 'lipogenic' environment could induce hepatic oxidative function, potentially influencing the severity of hepatic insulin resistance.
Article
Endocrinology & Metabolism
Ines Sousa-Lima, Hyun Jeong Kim, John Jones, Young-Bum Kim
Summary: NAFLD, affecting 25% of the global population, is closely linked with obesity and insulin resistance. The role of Rho-kinase (ROCK) in hepatic lipid homeostasis maintenance and its potential therapeutic implications in NAFLD and fibrosis have been highlighted in recent studies.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Food Science & Technology
Jun Wang, Xue Tang, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi, Peng Zhou
Summary: The study demonstrates that lycopene can alleviate myocardial dysfunction and energy metabolism issues induced by Dityrosine, by improving mitochondrial performance and reducing oxidative stress to enhance heart health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang
Summary: This study found that FGF9 expression was increased in the livers of diet-induced obese mice, and knockdown exacerbated the fatty liver phenotype while overexpression alleviated hepatic steatosis and improved insulin sensitivity. Mechanistically, FGF9 inhibits genes involved in lipogenesis and increases genes involved in fatty acid oxidation, reducing cellular lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Kai Liang
Summary: CPT1A is a rate-limiting enzyme in fatty acid β-oxidation, and its dysfunction can lead to metabolic disorders and various cancers. Inhibition of CPT1A could be a promising therapeutic strategy for cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Lin Zhu, Jianfeng Huang, Yi Wang, Zaiqing Yang, Xiaodong Chen
Summary: The study revealed the important role of chemerin in hepatic lipid metabolism, with its effects on lipid synthesis being mediated through GPR1. Free fatty acids and insulin were found to inhibit chemerin expression, while the key lipogenic transcription factor SREBP1c suppressed chemerin mRNA expression.
Article
Biochemistry & Molecular Biology
Enxiang Zhang
Summary: PLIN5 plays a crucial role in regulating mitochondrial-mediated lipogenesis and the interaction between lipid droplets and mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Veronica Miguel, Jessica Tituana, J. Ignacio Herrero, Laura Herrero, Dolors Serra, Paula Cuevas, Coral Barbas, Diego Rodriguez Puyol, Laura Marquez-Exposito, Marta Ruiz-Ortega, Carolina Castillo, Xin Sheng, Katalin Susztak, Miguel Ruiz-Canela, Jordi Salas-Salvado, Miguel A. Martinez Gonzalez, Sagrario Ortega, Ricardo Ramos, Santiago Lamas
Summary: The study found that promoting fatty acid oxidation to increase mitochondrial oxidative metabolism can protect against kidney fibrosis, as demonstrated in animal models and patients with chronic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Raghu Ramanathan, Ahmad Hassan Ali, Jamal A. Ibdah
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global pandemic strongly associated with metabolic syndromes. Metabolic-associated fatty liver disease (MAFLD) is suggested as a more appropriate term to describe the disease, emphasizing the role of metabolic dysfunction. Mitochondrial dysfunction plays a significant role in NAFLD development and targeting mitochondria shows promise for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yea-Jin Park, Min-gyu Seo, Divina C. Cominguez, Insik Han, Hyo-Jin An
Summary: This study demonstrated that Atractylodes chinensis can effectively reduce weight gain and adipose tissue expansion, attenuate adipogenic and enhance fatty acid oxidation in obese mice, while significantly upregulating the expression levels of AMP-activated kinase (AMPK) and sirtuin 1 (SIRT1).