Article
Food Science & Technology
Fengguang Pan, Zhuanzhang Cai, Huifang Ge, Sitong Ma, Yiding Yu, Jingbo Liu, Ting Zhang
Summary: Soybean meal peptides (SPs) exhibited potent antioxidant capacity and showed hepatoprotective potential by increasing cell viability, reducing oxidative stress, and alleviating alcohol-induced liver injury without toxicity. Transcriptome analysis suggested that the hepatoprotective effects of SPs may be related to genes involved in inflammation, lipid metabolism, and oxidation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Yali Yu, Shiyao Guan, Mengmeng Feng, Lijun Wang, Feng Gao
Summary: Albumin peptide fractions from corn germ meal (APF4) have a hepatoprotective effect on acute alcoholic liver damage in mice. APF4 at a dose of 800 mg/kg/bw significantly enhanced alcohol metabolism, reduced liver enzyme levels, decreased blood alcohol concentration, and increased antioxidant activity. These findings suggest that APF4 protects against alcohol-induced liver damage.
Article
Immunology
Ziheng Yang, Jie Zhang, Yan Wang, Jing Lu, Quan Sun
Summary: This study reveals that Cav1 deficiency in mice provides protection against acute liver injury, reducing hepatocyte degeneration, necrosis, and apoptosis as well as lowering ALT levels. Cav1 is also crucial for the polarization of hepatic macrophages, with its deficiency inhibiting the polarization towards the M1 phenotype. These findings suggest that Cav1 expressed in macrophages could be a potential therapeutic target for acute liver injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Lun Hung, Yi-Ting Hsiao, Yi-Shiou Chiou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: Piceatannol shows hepatoprotective effects by improving liver function, reducing collagen deposition, and inhibiting hepatic oxidative damage induced by CCl4 through regulating the TGF-beta/Smad signaling pathway and increasing glutathione and catalase activity.
Article
Chemistry, Medicinal
Mengge Ma, Lin Chen, Zhishu Tang, Zhongxing Song, Xin Kong
Summary: This study evaluated the hepatoprotective effect of Carthamus tinctorius L. leaf extract on chronic liver injury and found that it may exert its effects through antioxidation, anti-inflammation, and modulation of TLRs/NF-kappa B and PI3K/AKT pathways.
Article
Pharmacology & Pharmacy
Maaly Abd Elmaaboud, Haidy Khattab, Shahinaz Shalaby
Summary: Linagliptin may prevent the progression of liver fibrosis by suppressing oxidative stress, TGF-beta 1, and mTOR, leading to improved liver injury and fibrosis.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xichuan Wei, Chuanhong Luo, Yanan He, Haozhou Huang, Fei Ran, Wei Liao, Peng Tan, Sanhu Fan, Yuan Cheng, Dingkun Zhang, Junzhi Lin, Li Han
Summary: This study evaluated the hepatoprotective effects of Triphala extracts obtained by different methods in a mouse model of CCl4-induced liver injury. The findings indicate that ultrasonic extraction of Triphala was the most effective in preventing acute liver injury induced by CCl4.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Shameenii A. P. P. Thanebal, Senty Vun-Sang, Mohammad Iqbal
Summary: The study demonstrated that Pandanus amaryllifolius has antioxidant properties and can protect rats from acute hepatic damage caused by carbon tetrachloride. The extract contains various phytochemical constituents, showing significant antioxidant enzyme activity and reducing the extent of liver damage.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Tomislav Kostic, Dejan Popovic, Zoran Perisic, Dragana Stanojevic, Sonja Dakic, Sandra Saric, Danijela Djordjevic Radojkovic, Svetlana Apostolovic, Nenad Bozinovic, Snezana Ciric Zdravkovic, Stefan Milutinovic, Bojan Maricic, Nikola Zivkovic, Mladjan Golubovic, Miodrag Djordjevic, Radomir Damjanovic, Abraham Bell, Boris Dindic
Summary: The study demonstrates that aminoguanidine has a significant hepatoprotective effect in acute liver damage induced by CCl4, attributed to its antioxidant effects, inhibition of pro-oxidative and pro-inflammatory mediators, and induction of damaged hepatocytes into apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Vicenc Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
Summary: Chemotherapy-induced hepatotoxicity is a significant concern in cancer treatment, but curcumin has emerged as a potential strategy to mitigate this adverse effect. By targeting specific molecular mechanisms, curcumin exhibits anti-inflammatory, antioxidant, antifibrotic, and hypolipidemic properties that can help prevent and reduce chemotherapy-induced liver injury. Further clinical investigation is needed to demonstrate the efficacy of bioavailable curcumin formulations as hepatoprotective agents in cancer patients.
Article
Oncology
Yu Nie, Bo Huang, An-Ling Hu, Yun-Yan Xu, Yan Zou, Yun Liu, Jie Liu
Summary: The study found that cadmium has inhibitory effects on chemically induced liver tumors, which may be related to the deficiency of metallothionein in tumors and the induction of TNF-α in tumor cells.
Article
Immunology
Samia Salem Sokar, Mahmoud Abdelrahman Alkabbani, El-Sayed Akool, Sally El- Sayed Abu-Risha
Summary: The study demonstrated that carvedilol, crocin, and their combination have significant protective effects against leflunomide-induced liver injury. The combination treatment was found to be more effective than either drug alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mirac Bakdemir, Ebru Cetin
Summary: EP, as an antioxidant and anti-apoptotic agent, has been shown to protect rat liver against CCl4-induced acute liver injury.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Jian Ren, Sijin Li, Chunli Song, Xiaohong Sun, Xiaolan Liu
Summary: This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice, possibly attributed to the antioxidant and anti-inflammatory activities of BSPs.
JOURNAL OF FUNCTIONAL FOODS
(2021)