Journal
JOURNAL OF FLUORESCENCE
Volume 21, Issue 3, Pages 1155-1164Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10895-010-0793-z
Keywords
Symmetric ligands; Transition metal; Fluorescence studies; Salt dependence studies; Toxicity studies
Funding
- UGC (New Delhi)
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Three symmetric ligands 7-methyl dipyrido-[3,2-a;2',3'-c]phenazine (dppz-CH3), 7-nitro dipyrido-[3,2-a;2',3'-c]phenazine (dppz-NO2) and benzo[i]dipyrido-[3,2-a;2',3'-c]phenazine (dppn) and their ruthenium(II) complexes [Ru(en)(2)(L)][ClO4](2) (en= ethylenediamine), L= dppz-CH3, dppz-NO2 and dppn have been synthesized and characterized by IR, H-1, C-13 NMR and Mass spectra. The interactions of these complexes with calf thymus DNA have been investigated by spectrophotometric, spectrofluorimetric, circular dichroism, viscosity and thermal denaturation studies. As the planar extension of the intercalative ligand increases, the interaction of the complex with DNA increases, indicating that the size and shape of the intercalalative ligand has a marked effect on the strength of interaction. The plot of log K versus log [Na+] yield a slope of -1.26, -1.53, -1.60 for the complexes 1, 2 and 3 respectively. These three complexes have been found to promote the cleavage of plasmid pBR 322 DNA upon irradiation.
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