Article
Biochemistry & Molecular Biology
Qichen Pan, Yunchao Ban, Suliman Khan
Summary: The study demonstrated that calycosin significantly inhibits the fibril formation of α-syn in a concentration-dependent manner, preventing α-syn amyloid-triggered neurotoxicity. By modifying the aggregation pathway, calycosin promotes the formation of non-toxic species, restoring SOD/CAT activity and GSH content while reducing ROS levels and caspase-3 activity. This research provides valuable insights into the mechanism of α-syn amyloid inhibition by calycosin and suggests the development of small molecules-based therapeutic platforms for Parkinson's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Lanlan Yu, Ruonan Wang, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang, Yuxing Yao, Xiaoguang Wang, Chenxuan Wang
Summary: Scanning tunneling microscopy (STM) is used to distinguish 18 coexisting conformational substates of the β-strand of hIAPP 8-37 and analyze the peptide-peptide interactions. This method also validates the existence of multiple conformations in other β-sheet peptide assemblies. The results provide insights into the conformational ensemble and interpeptide interactions in β-sheet peptide assembly.
ACS CENTRAL SCIENCE
(2023)
Article
Polymer Science
Carlos Noble Jesus, Rhys Evans, Joe Forth, Carolina Estarellas, Francesco Luigi Gervasio, Giuseppe Battaglia
Summary: The study presents the design, simulation, synthesis, and reversible self-assembly of nanofibrils using polyhistidine-based oligopeptides. The inclusion of aromatic amino acids in the histidine block leads to the formation of amyloid-like fibrils with distinct antiparallel beta-strands. The structures undergo self-assembly in response to pH changes, offering potential for biotechnological and biomedical applications with pH-responsive fibrils in a physiologically relevant range.
Article
Chemistry, Multidisciplinary
Qiantao Song, Yi Li, Zhicheng Jin, Hai Liu, Matthew N. Creyer, Wonjun Yim, Yanping Huang, Xiaobing Hu, Tengyu He, Yajuan Li, Shana O. Kelley, Lingyan Shi, Jiajing Zhou, Jesse V. Jokerst
Summary: This study reports the mild and unique formation of luminescent spherulites at room temperature using benzene-1,4-dithiol. These spherulites not only exhibit robust structure but also show broad clusterization-triggered emission. They also demonstrate biocompatibility and efficient cellular uptake, making them valuable as traceable drug carriers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
Mantas Ziaunys, Kamile Mikalauskaite, Andrius Sakalauskas, Vytautas Smirnovas
Summary: The aggregation of amyloidogenic proteins is related to various diseases, with limited treatment options currently available. The challenge in the discovery of potential anti-amyloid molecules lies in identifying the actual inhibitors from complex mixtures. This study successfully scavenged potential aggregation-inhibiting molecules from different compounds and effectively separated them from the aggregates.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Tongtong Hou, Nan Zhang, Chaoren Yan, Minling Ding, Huizhe Niu, Ping Guan, Xiaoling Hu
Summary: This study developed a curcumin lysozyme-imprinted nanosphere (CUR-MIMS) that effectively inhibited the aggregation of lysozyme and showed good biocompatibility, demonstrating its potential as a therapeutic platform for amyloidosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mantas Ziaunys, Andrius Sakalauskas, Tomas Sneideris, Vytautas Smirnovas
Summary: Protein aggregation into amyloid fibrils is associated with various disorders, but the mechanisms behind the conversion of non-harmful proteins into such aggregates are not fully understood. Recent studies suggest that multiple types of protein aggregates may co-exist in tissues of patients with amyloid-related disorders, potentially influencing each other.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Boris B. Kharkov, Ivan S. Podkorytov, Stanislav A. Bondarev, Mikhail V. Belousov, Vladislav A. Salikov, Galina A. Zhouravleva, Nikolai R. Skrynnikov
Summary: Researchers have developed a mathematical theory to explain the results of rod-like fibrils in PFG NMR experiments, which has been validated in the Sup35 protein fibrils. Signals from disordered regions in the fibrils can be readily distinguished from signals representing small soluble species, paving the way for diffusion-sorted NMR experiments on complex amyloidogenic samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Muhammad Adnan, Haidi D. Fiedler, Javed Ali, Muhammad Idrees
Summary: The interaction between pyrene and Fe3+, Cu2+, Cr3+, Ni2+, Pb2+ was studied in 0.02 mol L-1 SDS. All studied heavy metal ions reduced the fluorescence intensity of pyrene, although the level of quenching varied. The quenching of pyrene by heavy metal ions was fitted to the Stern-Volmer equation. The Stern-Volmer constants (K-SV) were obtained, indicating the level of quenching and the sensitivity of the method. The method of pyrene fluorescence quenching by heavy metal ions is a fruitful approach for their determination in environmental samples.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Jozef Adamcik, Francesco Simone Ruggeri, Joshua T. Berryman, Afang Zhang, Tuomas P. J. Knowles, Raffaele Mezzenga
Summary: The nanomechanical properties and structural transitions of amyloid fibrils and microcrystals can be unraveled at the single aggregate scale using single molecule nanomechanical mapping and infrared nanospectroscopy techniques. Different morphologies of amyloid aggregates exhibit varying Young's moduli, with stiffness correlated to the content of intermolecular hydrogen bonding and the structure transition process.
Article
Chemistry, Multidisciplinary
Jiangtao Zhou, Ting Li, Mohammad Peydayesh, Mattia Usuelli, Viviane Lutz-Bueno, Jie Teng, Li Wang, Raffaele Mezzenga
Summary: Amyloid functional materials derived from oat globulin show diverse functionalities with rich polymorphism, reversible and irreversible fibrillization processes. These materials can be applied in water purification, sensors, and electrodes, with demonstrated sustainability against other protein sources for environmentally-efficient advanced materials and technologies.
Article
Optics
Sony Udayan, R. Lakshmi, B. Anugop, P. P. Saipriya, Ajith Vengellur, M. Kailasnath, V. P. N. Nampoori, Sheenu Thomas
Summary: The lasing characteristics of near infrared hemicyanine laser dye LDS 821 in different bio-nanotemplates were studied, showing promising results in DNA-surfactant complex and lysozyme amyloid fibrils. The well-resolved resonant modes and lower lasing threshold observed in these bio-nanotemplates suggest their potential use in biolaser fabrication. Random lasing behavior in lysozyme amyloid fibrils indicates the complexity of the lasing process in this system.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefanie-Elisabeth Heumueller, Annika C. Hornberger, Alina S. Hebestreit, Andre Hossinger, Ina M. Vorberg
Summary: This translation provides an overview of the characteristics of prion invasion, replication, and dissemination, highlighting the unconventional nature of prions and their reliance on host cell machinery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Wujoon Cha, Chaejeong Heo, Sanghyub Lee, Seok Joon Yun, Byeong Wook Cho, Taewoo Ha, Young Hee Lee
Summary: Charge transfer during the fibrillization of A ss proteins was investigated using Raman spectroscopy. The study revealed that small A ss monomers withdraw electrons, while fibrils donate electrons to graphene and molybdenum disulfide. Oligomers undergo transient charge states near the neutrality point.
Article
Multidisciplinary Sciences
Tejaswini Pradhan, Riddhiman Sarkar, Kevin M. Meighen-Berger, Matthias J. Feige, Martin Zacharias, Bernd Reif
Summary: Using solution-state NMR spectroscopy, the authors investigated the step-by-step process of protein misfolding from its native state to amyloid fibril state for the antibody light chain (AL) amyloidosis related protein FOR005. They focused on a mutated patient-derived λ-III AL variable domain FOR005. Unfavorable mutations in the protein structure resulted in its partial unfolding, ultimately leading to the formation of fibrils through electrostatic interactions and the aggregation of certain regions.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Rakesh Sharma, Geney Burang, Satish Kumar, Y. P. Sharma, Vikas Kumar
Summary: In the last decade, the development of novel beverages has been driven by a shift towards consuming foods with bioactive compounds and minimal calories. A low-calorie beverage enriched with apricot, aloe vera, aonla juice, and steviol glycoside was optimized in this study, leading to a product with high levels of functional compounds and reduced energy values, making it suitable for health-conscious consumers.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Food Science & Technology
Shweta Sharma, Bharti Shree, Deepika Sharma, Satish Kumar, Vikas Kumar, Rakesh Sharma, Rajni Saini
Summary: Microgreens have emerged as potential therapeutic functional foods for improving overall health through dietary supplementation. They have higher nutritional content and health benefits compared to mature plants. Factors like rapid land shrinkage and lifestyle modification have led to increased interest in microgreens production and quality maintenance.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Sahil Chaudhary, Vikas Kumar, Vishal Sharma, Rakesh Sharma, Satish Kumar
Summary: The global trend of consuming healthy meat without synthetic additives has led to the development of chitosan-based nanoemulsions, which are considered as a natural alternative for meat preservation. These nanoemulsions possess beneficial properties and can enhance the quality and safety of meat products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Environmental Sciences
S. Sharma, S. Kumar, V. Kumar, R. Sharma
Summary: Pesticides have played a significant role in modern agriculture, increasing productivity but also posing threats to the environment and human health. Restricting pesticide use, monitoring residue levels, and researching safer removal techniques are necessary for sustainable farming practices.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Pratishtha Bassi, Vikas Kumar, Ramandeep Kaur, Satish Kumar, Ramesh Kumar Saini, Sandeep Janghu
Summary: The risk of catastrophic conditions has increased due to changing environmental conditions, and herbal teas provide specific health benefits to consumers through phytochemicals. This study aims to optimize the dipping conditions for maximum extraction of phytochemicals.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agricultural Engineering
Satish Kumar, Shivani Sharma, Vikas Kumar, Ajay Sharma, Ramandeep Kaur, Rajni Saini
Summary: Jamun is a valuable therapeutic plant in India with various parts of the plant having therapeutic applications. The fruits are processed into different products, while the kernels contain numerous bioactive compounds with versatile applications. The plant has several traditional medicinal uses, especially in the treatment of diabetes. There is a need for scientific research to explore its potential in the food and pharmacy industry.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Food Science & Technology
Rajat Chandel, Vikas Kumar, Ramandeep Kaur, Satish Kumar, Ankit Kumar, Dharminder Kumar, Swati Kapoor
Summary: This paper explores the origin, distribution and classification, nutritional and bioactive potential, therapeutic potential, and valorization of Pyrus Pyrifolia (Sand Pear), and provides future prospects for its utilization.
NUTRITION & FOOD SCIENCE
(2023)
Review
Chemistry, Applied
Ramandeep Kaur, Ankit Kumar, Vikas Kumar, Satish Kumar, Ramesh Kumar Saini, Pratik Nayi, Rakesh Gehlot
Summary: This article discusses the applications and effects of explosion puffing (EP) technology in food processing, highlighting its potential in improving food quality and the challenges it faces.
Article
Food Science & Technology
Rajat Chandel, Vikas Kumar, Ramandeep Kaur, Satish Kumar, Mandeep Singh Gill, Rakesh Sharma, Rajesh V. V. Wagh, Dharminder Kumar
Summary: The effect of different sweeteners on the physiochemical, minerals, bioactive, and microstructure of sand pear cubes was investigated under different blanching time. Blanching led to an increase in water activity, total soluble solids (TSS), and total sugars of sand pear cubes. The retention of minerals and bioactive compounds was highest in the 2.5 min blanched samples. Among the sweeteners, low-calorie options such as aspartame, stevia, and sucralose resulted in lower TSS and total sugars with high retention of bioactive compounds.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Food Science & Technology
Atul Dhiman, Ramandeep Kaur, Rajat Chandel, Satish Kumar, Baljit Singh, Dharminder Kumar, Vikas Kumar, Rajat Suhag
Summary: This study investigated the effects of different blanching methods (dip blanching, steam blanching, and microwave blanching) on the physicochemical, functional, bioactive, and structural characteristics of okra. Blanching significantly changed the color and water activity of okra. Microwave blanching improved water and oil absorption capacity and rehydration ratio. The retention of bioactive compounds followed the trend of microwave blanching > steam blanching > dip blanching. The results suggest that microwave blanched okra powder has potential as a techno-functional food ingredient for industrial applications.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Green & Sustainable Science & Technology
A. Sharma, S. Kumari, S. Sharma, T. Singh, S. Kumar, A. Thakur, S. K. Bhatia, A. K. Sharma
Summary: Layered double hydroxides, also known as hydrotalcite-like compounds, are fascinating mineral materials with wide-ranging applications in catalysis, adsorbents, plastic, agriculture, and electronics. These materials have gained significant interest due to their ease of preparation, ability to intercalate different types of anions, high thermal stability, and biocompatibility. They also offer tailored acidity and basicity, basal spacing, memory effect, anion exchange capability, and a high surface area, making them versatile for various scientific and technological applications. This review focuses on rational design strategies, production, features, and applications of layered double hydroxides in energy and environmental fields, including their use as catalysts, energy storage components, and corrosion scavenging additives.
MATERIALS TODAY SUSTAINABILITY
(2023)
Review
Food Science & Technology
Tamanna Sharma, Prabhjot Kaur, Rajni Saini, Atul Dhiman, Satish Kumar, Ajay Sharma, Rakesh Sharma
Summary: Carrots, as root vegetables, are rich in nutrients and antioxidants. To maintain their nutritional composition and phytochemical profile, novel processing techniques have been developed. These innovative technologies not only meet consumer demands for safe and minimally processed products, but also result in environmentally-friendly and sustainable food production methods. The primary discoveries in this review focus on the minimal processing of carrots using innovative technologies to preserve their fundamental quality and improve bioavailability of bioactive components.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Review
Food Science & Technology
Priyanka Thakur, Rajat Suhag, Atul Dhiman, Satish Kumar
Summary: This review article provides an overview of black carrots, highlighting their nutritional and functional benefits, including antioxidants, vitamins, and minerals. It discusses the bioactive compounds present in black carrot and the effects of postharvest processing methods on preserving and stabilizing these compounds. Furthermore, it emphasizes the incorporation of black carrot into various food products and their impact on nutritional enhancement.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Priyanka Suthar, Satish Kumar, Vikas Kumar, Vishal Sharma, Atul Dhiman
Summary: Consumers' interest in health promoting foods has led to the development of novel biological compounds with diverse health benefits in the food industry. Postbiotics, as potential functional food compounds, have been well-studied in terms of their interaction, production, processing, and safety. The review explores the challenges and opportunities in improving growth mediums, cell lysis, extraction, characterization, stability, and applications of postbiotics in both the food and pharma industry, along with market trends, success stories, and safety concerns. Extensive investigations and clinical documentation have validated the physiological benefits and additional bioactivity of postbiotics, emphasizing the importance of documenting their bioactivity and safety.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Anika Panwar, Vikas Kumar, Atul Dhiman, Priyanka Thakur, Vishal Sharma, Ajay Sharma, Satish Kumar
Summary: Fruits and vegetables are highly perishable and play important roles in nutrition and economic sustainability. Nanoemulsion-based carriers have the potential to extend shelf life, improve quality, and reduce post-harvest losses. However, further research is needed to evaluate the safety and potential toxicity of these carriers.
ENVIRONMENTAL RESEARCH
(2024)