Journal
JOURNAL OF FLUID MECHANICS
Volume 759, Issue -, Pages -Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/jfm.2014.587
Keywords
biological fluid dynamics; blood flow; capsule/cell dynamics
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Funding
- NSF [CBET-0846293]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0846293] Funding Source: National Science Foundation
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We present the first full-scale computational evidence of intermittent and synchronized dynamics of red blood cells in shear flow. These dynamics are characterized by the coexistence of a tumbling motion in which the cell behaves like a rigid body and a tank-treading motion in which the cell behaves like a liquid drop. In the intermittent dynamics, we observe sequences of tumbling interrupted by swinging, as well as sequences of swinging interrupted by tumbling. In the synchronized dynamics, the tumbling and membrane rotation are observed to occur simultaneously with integer ratios of the rotational frequencies. These dynamics are shown to be dependent on the stress-free state of the cytoskeleton, and are explained based on the cell membrane energy landscape.
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