Article
Veterinary Sciences
Yuxin Yang, Jingyuan Kong, Yu Liu, Qinyao Wu, Yuying Cao, Jicheng Qiu, Lu Zhang, Xiaohui Gong, Fuhua Zhao, Xingyuan Cao, Jianzhong Wang
Summary: This study investigated the pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions in cats. The results showed no significant differences in major pharmacokinetic parameters between the two formulations and the blood profiles of cyclosporine were similar after administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jacqueline B. McCrea, Karsten Menzel, Craig Fancourt, Rose Witter, Tian Zhao, Jonathan A. Robbins, S. Aubrey Stoch, Marian Iwamoto
Summary: This study aimed to evaluate the effects of itraconazole, a prototypic ABCB1/ABCG2 inhibitor, on letermovir pharmacokinetics (PK) and the effects of letermovir on itraconazole PK. The results showed that coadministration of itraconazole with letermovir increased letermovir exposure, while it decreased itraconazole exposure. However, these changes are not considered clinically meaningful.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Yueyue Liu, Qian Zhang, Chao Lu, Wei Hu
Summary: The study evaluated the impact of itraconazole on the safety and pharmacokinetics of pyrotinib in Chinese healthy adults. Co-administration of itraconazole substantially increased the exposure to pyrotinib without causing serious adverse events, indicating good tolerability of the combination therapy in healthy participants.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Keli Wang, Juefang Ding, Xianjing Li, Wenjing Guo, Xingyu Zhu, Yue Su, Luning Sun, Huan Zhou, Li Ding
Summary: This study investigated the drug-drug interactions of Youkenafil. The results showed that Youkenafil was mainly metabolized through CYP3A4/5. Itraconazole increased the concentration of Youkenafil and its metabolite M1, while rifampicin reduced the concentration of Youkenafil. Therefore, co-administration of Youkenafil with potent inhibitors or inducers of CYP3A4/5 should be avoided or carefully monitored.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jurjen S. Kingma, Desiree M. T. Burgers, Valerie M. Monpellier, Marinus J. Wiezer, Heleen J. Blusse Van Oud-Alblas, Janelle D. Vaughns, Catherine M. T. Sherwin, Catherijne A. J. Knibbe
Summary: Bariatric surgery can affect the absorption and metabolism of drugs, leading to earlier and potentially higher peak concentrations of orally administered drugs with inconsistent effects on concentrations and exposure. Prescribing liquid formulations to bariatric patients is beneficial, although the high sugar content may be a concern. While exposure to some drugs remains unchanged, the timing after surgery can impact drug absorption profiles.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Immunology
Fleur M. Keij, Stef Schouwenburg, Rene F. Kornelisse, Tim Preijers, Fatima Mir, Pieter Degraeuwe, Leo M. Stolk, Arianne van Driel, Sandra Kenter, Jacqueline van der Sluijs, Jojanneke Heidema, Paul C. P. den Butter, Irwin K. M. Reiss, Karel Allegaert, Gerdien A. Tramper-Stranders, Birgit C. P. Koch, Robert B. Flint
Summary: This study describes the metabolism of oral and intravenous amoxicillin in neonates and provides dosage recommendations for different age groups. Oral amoxicillin therapy is an effective, cost-effective, and convenient alternative treatment for neonates.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Yutao Lou, Feifeng Song, Mengting Cheng, Ying Hu, Yitao Chai, Qing Hu, Qiyue Wang, Hongying Zhou, Meihua Bao, Jinping Gu, Yiwen Zhang
Summary: This study investigated the influence of three triazole antifungals (voriconazole, itraconazole, and fluconazole) on the pharmacokinetics of osimertinib in rats. The results showed that voriconazole and fluconazole significantly changed the pharmacokinetics of osimertinib, while itraconazole had a slight effect.
Article
Veterinary Sciences
Ricardo de Matos, Brendan P. Noonan, Deanna M. W. Schaefer, James Morrisey, Curtis Dewey, Elizabeth L. Buckles, Dawn Boothe
Summary: The study demonstrated that zonisamide has good pharmacokinetic properties in chickens, with a safe and effective dose of 20 mg/kg orally every 12 hours. However, two birds developed immune-mediated haemolytic anaemia as a side effect.
VETERINARY MEDICINE AND SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Alex K. Lyashchenko, Serge Cremers
Summary: The personalized dosing of oral small molecule anticancer drugs based on patient blood levels, known as therapeutic drug monitoring (TDM), has the potential to improve treatment effectiveness by maximizing drug efficacy and minimizing toxicity. However, this approach has not been widely accepted in oncology due to lack of evidence demonstrating improved clinical outcomes, leading to reluctance from oncologists and insurance reimbursement, potentially impacting patients receiving incorrect drug doses.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Siva Rama Raju Kanumuri, Jessica Mamallapalli, Robyn Nelson, Christopher R. McCurdy, Carol A. Mathews, Chengguo Xing, Abhisheak Sharma
Summary: This study examined the clinical pharmacokinetics of kava in healthy volunteers, finding higher exposure after single-dosing and longer duration of exposure after multiple doses.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
T. Nguyen, M. Oualha, C. Briand, M. Bendavid, A. Beranger, S. Benaboud, J-M Treluyer, Y. Zheng, F. Foissac, S. Winter, I Gana, S. Boujaafar, V Lopez, R. Berthaud, Z. Demir, N. Bouazza, D. Hirt
Summary: This study characterized ganciclovir pharmacokinetics in children and optimized dosing schemes for curative or preventive treatment of CMV infections. Dosing recommendations were provided based on body weight and estimated glomerular filtration rate, and individualized therapeutic drug monitoring was suggested for dose refinement.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Article
Pharmacology & Pharmacy
Robert P. Hunter, Roy Madigan
Summary: This study evaluated the effectiveness of four different formulations of itraconazole and amiodarone. The results showed high variability in serum concentration of itraconazole within the treatment groups, and dosing with the compounded suspensions proved to be challenging.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Franziska Kluwe, Robin Michelet, Wilhelm Huisinga, Markus Zeitlinger, Gerd Mikus, Charlotte Kloft
Summary: This study aimed to evaluate and compare the predictive performance of nonlinear mixed-effects (NLME) models for model-informed precision dosing (MIPD) of voriconazole, a broad-spectrum antifungal drug. The results showed that a published 'hybrid' model had the best predictive performance, but all NLME models had only modest predictive performance, indicating the need for further improvement in model development and evaluation.
CLINICAL PHARMACOKINETICS
(2023)
Article
Microbiology
Adriana M. Rauseo, Patrick Mazi, Phoebe Lewis, Bruce Burnett, Stuart Mudge, Andrej Spec
Summary: The study found that under fasted conditions, SUBA-itraconazole (S-ITZ) capsules had less absorption variability compared to conventional itraconazole (C-ITZ) capsules.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
