Article
Environmental Sciences
Rongrui Liu, Tim R. Zacharewski, Rory B. Conolly, Qiang Zhang
Summary: A human PBPK modeling framework for DLC mixtures was developed, which can flexibly simulate the exposure and internal burden of DLC mixtures. The results of simulations showed that tissue burdens of DLC mixtures were consistently lower than those of single exposure, except for the liver. The model also demonstrated marked differences in the contributions of individual congeners to blood or tissue toxic equivalency (TEQ) values compared to intake TEQ.
Article
Environmental Sciences
Sabrina Battisti, Paola Scaramozzino, Carlo Boselli, Fabio Busico, Sesto Berretta, Marcello Sala, Bruno Neri
Summary: This study reports the data of polychlorinated dibenzo-p-dioxins (PCDDs), -furans (PCDFs), and polychlorinated biphenyls dioxin-like (dl PCBs) measured in a total of 260 samples of the dairy supply chain collected over a period of 7 years (2011-2017) in the Latium region (Italy). The study found that sheep milk had the highest levels of pollutants, while buffalo milk had relatively lower levels. This study provides important reference values for background contamination of the dairy supply chain in the Latium region.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ya Zhang, Xiaobo Zheng, Pu Wang, Qinghua Zhang, Zhengwang Zhang
Summary: The study found that little owls in Beijing were at the highest risk of exposure to PCDD/Fs and PCBs, while PCB levels in common kestrels have been decreasing in the past decade.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Layra G. Cintron-Rivera, Nicole Burns, Ratna Patel, Jessica S. Plavicki
Summary: Human exposure to environmental pollutants can negatively impact embryonic development and health outcomes. This study utilized zebrafish as a model to explore the cellular and transcriptional targets of TCDD-induced craniofacial malformations. The findings reveal a reduction in jaw and pharyngeal chondrocytes, decreased collagen deposition, and impaired development of tissues derived from specific progenitor cells.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Sophie Schroder, Ma-Fresnedo San-Roman, Inmaculada Ortiz
Summary: This study provides a detailed kinetic analysis of the formation of dioxins and furans during the photocatalytic treatment of aqueous samples containing Triclosan, and determines the toxicity of the samples in terms of toxic equivalents (TEQ). TEQ values were calculated using the group of 17 congeners with higher toxicity, and multivariable analysis and linear regression were applied to reduce the significant number of congeners and optimize the analytical effort.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Ding Gao, Ziwei Chen, Jianbo Zhang, Weiguang Xu, Donghui Wen, Jianxin Hu
Summary: Using the UNEP standardized toolkit, this study inventoried the production and release of PCDD/Fs from 6 major sectors in China from 2003 to 2020, projecting until 2025 based on current control measures. The results showed a decline in production and release after 2007, but a reversal in trend after 2015 due to expansion of sectors and lack of control technology. Environmental release continued to decrease, but slower after 2015. The study also emphasized the importance of OCDF, OCDD, PeCDF, and TCDF, and the need for strengthened regulations and control measures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Juan Munoz-Arnanz, Alice Bartalini, Luis Alves, Marco FL. Lemos, Sara C. Novais, Begona Jimenez
Summary: This study investigated the contamination levels of blue sharks from the North East Atlantic in 2019, specifically focusing on PCBs, PCDD/Fs, and PBDEs. The results showed an increase in PBDE loads, potentially reflecting the growing environmental presence of these pollutants. The different congener profiles observed in blue sharks from different geographical areas highlight the species' potential as a bioindicator of regional pollution. Significant differences in pollutant concentrations between muscle and liver were observed, likely due to varying toxicokinetics. The concentrations of PCBs and dioxin-like POPs in muscle were below the EU maximum allowed levels, while concentrations in the liver exceeded the European levels for tolerable intake. PBDE concentrations surpassed the EQS established by the European Water Framework Directive in both liver and muscle samples.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Chu Wang, Shujun Dong, Pu Wang, Yanfen Hao, Ruiguo Wang, Su Zhang, Yaxin Wang, Mengdie Fan, Qinghua Zhang, Guibin Jiang
Summary: The research highlighted the importance of updated assessments on transfer of toxic substances in poultry products to better understand human exposure risks. Results showed that different exposure levels of contaminants in feed can affect the transfer rate and depletion rate in eggs, with hens with higher laying rates expediting the clearance of toxic substances. Lower chlorinated congeners tend to be retained in eggs, while transfer rates of toxic substances were lower than previous studies, possibly due to short exposure time and low bioavailability of contaminants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Nutrition & Dietetics
Wurood Hantoosh Neamah, Alex Rutkovsky, Osama Abdullah, Kiesha Wilson, Ryan Bloomquist, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study demonstrates that Resveratrol (RSV), an AhR antagonist, reduces the induction and function of murine myeloid-derived suppressor cells (MDSCs) induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). RSV reverses the effects of TCDD on macrophages and dendritic cells, as well as the upregulation of critical molecules involved in TCDD-mediated induction and immunosuppressive functions of MDSCs. RSV treatment decreases the energetic demands induced by TCDD. These findings suggest the potential use of RSV to attenuate the immunosuppressive properties of MDSCs.
Article
Environmental Sciences
Alexis Lopez, Kent Sorenson, Jeffrey Bamer, Randa Chichakli, Thomas Boivin, Daniel Moats
Summary: During the remediation of dioxin contamination at Danang airport, Incremental Sampling Methodology (ISM) was used to provide a more reliable estimate, better capturing distributional heterogeneity and reducing sampling variability compared to traditional methods.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Environmental Sciences
Ha-Hyun Lee, Sunggyu Lee, Jung Suk Lee, Hyo-Bang Moon
Summary: Limited studies have been conducted on polychlorinated naphthalenes (PCNs) in the coastal environment worldwide. Analytical methods were optimized for 18 PCN congeners in sediment, showing ubiquitous contamination in industrialized coastal regions of Korea. Industrial activities are primary sources of PCNs, with CNs 73 and 52 being predominant congeners in sediment samples.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Engineering, Environmental
Bao-Anh Thi Nguyen, Ju-Liang Hsieh, Shou-Chen Lo, Sui-Yuan Wang, Chun-Hsiung Hung, Eugene Huang, Shih-Hsun Hung, Wei-Chih Chin, Chieh-Chen Huang
Summary: In this study, the endophytic bacterium Burkholderia cenocapacia 869T2 was found to degrade the most toxic dioxin congener TCDD by nearly 95% after one-week of an aerobic incubation, with a potential general dioxin degradation pathway proposed. The investigation also revealed the crucial role of a catabolic gene, L-2-haloacid dehalogenase (2-HAD), in dioxin dehalogenation in aerobic conditions. Transcriptional analysis indicated high gene expressions of catabolic genes involved in dioxin metabolism in the presence of TCDD.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Marine & Freshwater Biology
Layra G. Cintron-Rivera, Gabrielle Oulette, Aishwarya Prakki, Nicole M. Burns, Ratna Patel, Rachel Cyr, Jessica Plavicki
Summary: Dioxins are highly toxic and persistent environmental pollutants that have been shown to act as developmental teratogens. The most potent dioxin congener, TCDD, impairs nervous system, cardiac, and craniofacial development by activating the aryl hydrocarbon receptor (AHR). In zebrafish, TCDD exposure leads to craniofacial malformations through downregulation of sox9b, a member of the SoxE gene family. TCDD also affects the development of the zebrafish auditory system, specifically the otic vesicle, leading to structural deficits and altered collagen expression in the ears.
AQUATIC TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jie Cheng, Bo-en Li, Jinghui He, Peilong Wang
Summary: The detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) in milk samples using surface-enhanced Raman spectroscopy (SERS) with a bifunctional substrate consisting of Au nanoparticles embedded in a zirconium-based metal-organic framework shell (AuNP/Zr-MOF) is reported for the first time. The detection limit for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic PCDD, is as low as 1.2 parts per trillion (ppt) in real milk samples with interfering substances, making it the lowest among all reported methods.
Article
Environmental Sciences
Xiaotong Su, Yucheng Zhang, Nora F. Y. Tam, Xiaolan Lao, Meiling Zhong, Qihang Wu, Yingheng Fei, Huifang Lei, Zihui Chen, Bixian Mai, Laiguo Chen
Summary: Informal e-waste recycling poses a health and environmental danger due to the presence of PCDD/Fs. This study investigated the vertical distribution characteristic of PCDD/Fs in an abandoned e-waste dismantling site in Guiyu, China, as well as the nearby paddy field and stream. The concentrations of PCDD/Fs decreased with increasing soil depth, and the main source was identified as e-waste recycling. The similarity of PCDD/Fs distribution between the non-plough layer of paddy field and sediments was possibly due to water management.
JOURNAL OF SOILS AND SEDIMENTS
(2023)
Article
Environmental Sciences
Lauren A. Wise, Amelia K. Wesselink, Samantha Schildroth, Antonia M. Calafat, Traci N. Bethea, Ruth J. Geller, Chad M. Coleman, Victoria Fruh, Birgit Claus Henn, Julianne C. Botelho, Quaker E. Harmon, Maya Thirkill, Ganesa R. Wegienka, Donna D. Baird
Summary: The study found that factors such as age, income, education, water intake, alcohol consumption, and seafood consumption were positively associated with several PFAS levels in women. Smoking was positively associated with MeFOSAA, while body mass index was inversely associated with most PFAS. Reproductive factors such as parity, lactation, recent birth, and menstrual bleeding intensity showed strong associations with PFAS concentrations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Heidi T. Cueto, Bjarke H. Jacobsen, Anne Sofie Dam Laursen, Anders H. Riis, Elizabeth E. Hatch, Lauren A. Wise, Ellen Trolle, Henrik Toft Sorensen, Kenneth J. Rothman, Amelia K. Wesselink, Sydney Willis, Benjamin R. Johannesen, Ellen M. Mikkelsen
Summary: Preconception dietary folate intake is positively associated with fecundability in a monotonic pattern. Two internet-based cohort studies found that compared to a dietary folate intake of >= 400 μg/day, intake of 250-399 μg/day and <250 μg/day were associated with decreased fecundability. Additionally, low dietary folate intake (<250 μg/day) combined with folic acid supplementation was also associated with reduced fecundability.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Taiyao Wang, Zahra Zad, Sydney K. Willis, Tanran R. Wang, Amelia K. Wesselink, Tammy Jiang, Elizabeth E. Hatch, Lauren A. Wise, Ioannis Ch Paschalidis
Summary: Using data from the North American preconception cohort study, the researchers developed models to predict the probability of conception, achieving a performance of around 70% in the area under the receiver operating characteristic curve (AUC).
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Amelia K. Wesselink, Tanran R. Wang, Matthias Ketzel, Ellen M. Mikkelsen, Jorgen Brandt, Jibran Khan, Ole Hertel, Anne Sofie D. Laursen, Benjamin R. Johannesen, Mary D. Willis, Jonathan Levy, Kenneth J. Rothman, Henrik T. Sorensen, Lauren A. Wise, Elizabeth E. Hatch
Summary: In a preconception cohort study of Danish women, residential exposures to PM2.5 and PM10 were associated with reduced fecundability, while other air pollutants did not show a significant association.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Editorial Material
Public, Environmental & Occupational Health
Amelia K. Wesselink, Gregory A. Wellenius
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Amelia K. Wesselink, Sydney K. Willis, Anne Sofie Dam Laursen, Ellen M. Mikkelsen, Tanran R. Wang, Ellen Trolle, Katherine L. Tucker, Kenneth J. Rothman, Lauren A. Wise, Elizabeth E. Hatch
Summary: The study found that the intake of protein-rich foods before pregnancy was largely unrelated to the risk of spontaneous abortion, with the exception of seafood, which showed different effects on SAB risk in Denmark compared to North America.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Samantha Schildroth, Lauren A. Wise, Amelia K. Wesselink, Traci N. Bethea, Victoria Fruh, Kyla W. Taylor, Antonia M. Calafat, Donna D. Baird, Birgit Claus Henn
Summary: This study found that personal care product use, diet, and contraceptive measures may be the main sources of exposure to multiple non-persistent endocrine disrupting chemicals among reproductive-aged Black women.
Article
Public, Environmental & Occupational Health
Sissel Jessen Weissert, Ellen Margrethe Mikkelsen, Bjarke H. Jacobsen, Elizabeth E. Hatch, Amelia K. Wesselink, Lauren A. Wise, Kenneth J. Rothman, Henrik T. Sorensen, Anne Sofie Dam Laursen
Summary: This study found no meaningful association between consumption of organic food and fecundability in couples trying to conceive. However, slightly higher fecundability was observed among participants with less than 3 cycles of pregnancy attempt time when they consumed more organic food.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Holly Michelle Crowe, Elizabeth Elliott Hatch, Tanran R. Wang, Charles Robert Horsburgh, Ellen Margrethe Mikkelsen, Wendy Kuohung, Lauren Anne Wise, Amelia Kent Wesselink
Summary: Periconceptional antibiotic use was not significantly associated with the risk of spontaneous abortion in this study, possibly due to multiple factors.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Amelia K. Wesselink, Ganesa Wegienka, Chad M. Coleman, Ruth J. Geller, Quaker E. Harmon, Kristen Upson, Sharonda M. Lovett, Birgit Claus Henn, Erica E. Marsh, Nyia L. Noel, Donna D. Baird, Lauren A. Wise
Summary: This study found that cigarette smoking is associated with a lower incidence of uterine leiomyomata based on a prospective ultrasound study. However, there is no significant association between smoking and uterine leiomyomata growth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ruth J. Geller, Amelia K. Wesselink, Martha R. Koenig, Michael L. Eisenberg, Katherine L. Tucker, Elizabeth E. Hatch, Lauren A. Wise
Summary: This study found weak positive associations between male fatty acid intake and fecundability among couples planning pregnancy. However, no other fatty acid subtypes were significantly associated with fecundability. This study fills a knowledge gap regarding the association between male fatty acid intake and fecundability.
HUMAN REPRODUCTION
(2023)
Article
Immunology
Amelia K. Wesselink, Sharonda M. Lovett, Janice Weinberg, Ruth J. Geller, Tanran R. Wang, Annette K. Regan, Mary D. Willis, Rebecca B. Perkins, Jennifer J. Yland, Martha R. Koenig, Kenneth J. Rothman, Elizabeth E. Hatch, Lauren A. Wise
Summary: We conducted a prospective cohort study to examine the association between COVID-19 vaccination and menstrual cycle characteristics. Our findings suggest that COVID-19 vaccination is associated with a temporary increase in menstrual cycle length by 1 day, but not with other menstrual cycle characteristics.
Article
Environmental Sciences
Amelia K. Wesselink, Perry Hystad, Kipruto Kirwa, Joel D. Kaufman, Mary D. Willis, Tanran R. Wang, Adam A. Szpiro, Jonathan I. Levy, David A. Savitz, Kenneth J. Rothman, Elizabeth E. Hatch, Lauren A. Wise
Summary: This study found that ambient concentrations of PM2.5, NO2, and O3 were not significantly associated with reduced fecundability in both the U.S. and Canada. Different concentrations of these pollutants also had varying impacts on fecundability.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Amelia K. Wesselink, Annette K. Regan, Elizabeth E. Hatch, Kenneth J. Rothman, David A. Savitz, Tanran R. Wang, Krista F. Huybrechts, Sonia Hernandez-Diaz, Michael L. Eisenberg, Lauren A. Wise
Summary: COVID-19 vaccination in either partner at any time before conception is not associated with an increased rate of miscarriage.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
J. C. Bond, C. M. Coleman, J. J. Yland, A. K. Wesselink, T. Wang, M. Willis, E. E. Hatch, K. J. Rothman, D. Savitz, M. L. Eisenberg, L. A. Wise
Summary: This study found that female sleep duration had little association with spontaneous abortion (SAB), while male short sleep duration, female night work, and discrepancies in work schedules among partners had modest positive associations with SAB incidence.
HUMAN REPRODUCTION
(2023)