Article
Cell Biology
Chengcheng Zhang, Jingru Qin, Lu Yang, Zhiyao Zhu, Jia Yang, Wan Su, Haibin Deng, Zhongqi Wang
Summary: This study reveals that exosomes secreted from pulmonary adenocarcinoma cells enhance osteoclastogenesis and osseous resorption by downregulating neuropilin 2 expression. These findings shed light on the mechanism of osseous metastases in pulmonary carcinoma and provide a potential nanodrug for treating bone metastases.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Hsiao-Chi Tsai, An-Chen Chang, Chien-Chung Huang, Shun-Fa Yang, Chih-Hsin Tang
Summary: Osteoblasts and osteoclasts are crucial in the bone turnover cycle, and melatonin shows promising therapeutic potential for both osteoporosis and osteolytic bone metastasis by regulating bone metabolism, bone cell differentiation, and bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jian Zhang, Jiangmei Wu
Summary: This article discusses the role of exosomal miR-214 in bone metastasis of lung adenocarcinoma, suggesting that exosomal miR-214 may disrupt bone homeostasis by enhancing bone resorption, leading to bone metastasis. Furthermore, exosomal miR-214 facilitates intercellular communication between lung adenocarcinoma cells and osteoclasts, promoting the colonization and proliferation of cancer cells in the bone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dongqi Li, Chuanchun He, Fan Ye, En Ye, Hao He, Gong Chen, Jing Zhang
Summary: The overexpression of p62 in lung adenocarcinoma bone metastasis is significantly associated with more bone lesions, shorter overall survival rates, and shorter progression free survival rates. In vitro experiments showed that downregulation of p62 inhibited cell migration but not cell proliferation. The expression of p62 in autophagy flux changed inconsistently according to the switch of LC3I to LC3II in different autophagy conditions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu
Summary: CST6 inhibits osteolytic bone metastasis by suppressing osteoclastogenesis. It enters osteoclasts via endocytosis, inhibits cysteine protease CTSB, leading to up-regulation of SPHK1 which suppresses osteoclast maturation. Recombinant CST6 protein and peptides mimicking its function show potential in suppressing cancer cell-induced osteoclastogenesis and bone metastasis.
Article
Oncology
Alexus D. Kolb, Jinlu Dai, Evan T. Keller, Karen M. Bussard
Summary: The study demonstrates that educated osteoblasts can reduce osteoclastogenesis and bone resorption, providing a protective effect against bone metastatic breast cancer.
Article
Oncology
Ainiwaerjiang Abudourousuli, Suwen Chen, Yameng Hu, Wanying Qian, Xinyi Liao, Yingru Xu, Libing Song, Shuxia Zhang, Jun Li
Summary: Bone metastasis is a common and life-threatening complication of breast cancer. This study reveals that downregulation of NKX2-8 is significantly associated with breast cancer bone metastasis. The mechanism involves NKX2-8 interacting with HDAC1 to reduce histone acetylation and transcriptionally downregulate PTHrP expression. Targeting PTHrP effectively inhibits NKX2-8 downregulation-induced breast cancer bone metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Ying Cai, Chunlan Zhu, Yanfei Wang, Yiqian Jiang, Zhongxin Zhu
Summary: This study identified differentially expressed circRNAs in LUAD-BM using high-throughput sequencing and qRT-PCR, and predicted their potential functions and pathways. The results suggest that these differentially expressed circRNAs play important roles in the occurrence and development of LUAD-BM, and circ_0096442 may be a biomarker for LUAD-BM.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Ming Wu, Dewei Kong, Yan Zhang
Summary: Bone metastasis is a major complication in lung adenocarcinoma (ADC) patients, and identifying biomarkers for this disease is crucial. This study found that SPON2 plays a key role in promoting bone metastasis by activating the NF-kappa B pathway in ADC. These findings suggest that SPON2 could be a potential therapeutic target for future drug development.
Article
Multidisciplinary Sciences
Alice Yu, Yuanyuan Li, Irene Li, Michael G. Ozawa, Christine Yeh, Aaron E. Chiou, Winston L. Trope, Jonathan Taylor, Joseph Shrager, Sylvia K. Plevritis
Summary: The study introduces a graph-based algorithm REMI that predicts ligand-receptor (LR) interactions and reconstructs interactomes from RNA sequencing data. By leveraging single-cell transcriptomics data for cell type resolution and identifying LR prognostic signatures among tumor-stroma-immune subpopulations, the study confirmed an interaction associated with LUAD progression.
Article
Oncology
Peter Radeczky, Judit Moldvay, Janos Fillinger, Beata Szeitz, Bence Ferencz, Kristiina Boettiger, Melinda Rezeli, Krisztina Bogos, Ferenc Renyi-Vamos, Konrad Hoetzenecker, Balazs Hegedus, Zsolt Megyesfalvi, Balazs Dome
Summary: This study reveals a correlation between bone metastasis patterns and primary tumor location in LADC patients, with peripherally located tumors associated with rib and femoral metastases as well as improved survival outcomes.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhen Liu, Jiahao Liu, Yang Li, Hao Wang, Zixi Liang, Xiaojie Deng, Qiaofen Fu, Weiyi Fang, Ping Xu
Summary: The downregulation of VPS33B in tumors is a factor that promotes the progression of lung adenocarcinoma (LUAD). Mechanistic studies show that VPS33B inhibits EGFR Ras/ERK signaling, leading to reduced expression of oncogenic factors like c-Myc. Additionally, the interaction between VPS33B and NESG1 affects LUAD migration and invasion through different signaling pathways.
Review
Oncology
Yuying Liu, Xinyue Dong, Tao Li, Yanke Xing, Na Liu
Summary: This article reports a case of lung adenocarcinoma metastatic to the bladder and includes a literature review to provide clinicians with diagnostic and treatment experience and help avoid misdiagnosis and mistreatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chunliu Meng, Fang Wang, Minghong Chen, Hongyun Shi, Lujun Zhao, Ping Wang
Summary: This retrospective study aimed to investigate prognostic factors and develop a nomogram model for estimating survival in patients with advanced lung adenocarcinoma (LUAD) and bone-only metastasis (BOM). The study found that hematological variables were significant prognostic factors and adding Risk-H to the nomogram model improved the predictive accuracy of survival in LUAD patients with one to five BOM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Rong Li, Yanping Lin, Fengdi Hu, Yedan Liao, Jiadai Tang, Yan Shen, Heng Li, Jiangyan Guo, Lin Xie
Summary: The study found that TEX41 plays an important role in bone metastasis of lung adenocarcinoma. High expression of TEX41 is associated with poor prognosis in patients with lung adenocarcinoma. Inhibition of TEX41 can suppress the migration and metastasis of lung adenocarcinoma cells, while overexpression of TEX41 promotes these processes. By upregulating Runx2, TEX41 promotes autophagy in lung adenocarcinoma cells, thereby regulating migration, invasion and bone metastasis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ming-Cheng Chan, Wen-Cheng Chao, Shinn-Jye Liang, Chien-Hua Tseng, Hao-Chien Wang, Ying-Chun Chien, Kuang-Yao Yang, Wei-Chih Chen, Wann-Cherng Perng, Kuo-Chin Kao, Han-Chung Hu, Chau-Chyun Sheu, Wei-An Chang, Wen-Feng Fang, Yu-Mu Chen, Arthur S. Slutsky, Chieh-Liang Wu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Medicine, General & Internal
En-Shyh Lin, Wei-An Chang, Yang-Yi Chen, Ling-Yu Wu, Yi-Jen Chen, Po-Lin Kuo
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, Research & Experimental
Chau-Chyun Sheu, Wei-An Chang, Ming-Ju Tsai, Ssu-Hui Liao, Inn-Wen Chong, Po-Lin Kuo
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Ming-Ju Tsai, Yu-Chen Tsai, Wei-An Chang, Yi-Shiuan Lin, Pei-Hsun Tsai, Chau-Chyun Sheu, Po-Lin Kuo, Ya-Ling Hsu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Ming-Ju Tsai, Wei-An Chang, Ssu-Hui Liao, Kuo-Feng Chang, Chau-Chyun Sheu, Po-Lin Kuo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Medicine, General & Internal
Chau-Chyun Sheu, Wei-An Chang, Ming-Ju Tsai, Ssu-Hui Liao, Inn-Wen Chong, Po-Lin Kuo
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Yang-Yi Chen, Wei-An Chang, En-Shyh Lin, Yi-Jen Chen, Po-Lin Kuo
Article
Biochemistry & Molecular Biology
Wei-An Chang, Chia-Min Chen, Chau-Chyun Sheu, Ssu-Hui Liao, Ya-Ling Hsu, Ming-Ju Tsai, Po-Lin Kuo
Article
Biochemistry & Molecular Biology
Mei-Chuan Kuo, Wei-An Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu
Summary: Hypoxia-induced epithelial-to-mesenchymal transition (EMT) in proximal tubular epithelial cells (PTECs) is modulated by miR-545-3p-TNFSF10 interaction. TNFSF10 attenuates EMT induced by hypoxia in PTECs. These findings provide new insights into the unique regulation of miR-545-3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
Review
Biochemistry & Molecular Biology
Ming-Ju Tsai, Wei-An Chang, Cheng-Hao Chuang, Kuan-Li Wu, Chih-Hung Cheng, Chau-Chyun Sheu, Ya-Ling Hsu, Jen-Yu Hung
Summary: Cancer is still a leading cause of death worldwide. Changes in the tumor microenvironment, especially dysregulated immunity, may contribute to carcinogenesis and cancer progression. The cysteinyl leukotriene pathway plays an important role in cancer, particularly through the CysLT(1) receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wei-An Chang, Ming-Ju Tsai, Jen-Yu Hung, Kuan-Li Wu, Ying-Ming Tsai, Yung-Chi Huang, Chao-Yuan Chang, Pei-Hsun Tsai, Ya-Ling Hsu
Summary: This study investigated the functional profiles of NK cells in the hypoxic tumor microenvironment of lung cancer, revealing downregulation of CD226 and functional repression of NK cells after treatment with lung cancer-derived extracellular vesicles containing miR-150-5p. NK cells from lung cancer patients showed lower expression of CD226, pro-inflammatory, pro-angiogenic, and tumorigenesis phenotype. Inhibition of miR-150 improved tumor surveillance by reversing CD226 expression and reinstating cytotoxic NK cell activity, highlighting a new scenario for the pro-inflammatory and pro-angiogenic activities of NK cells in the hypoxic TME in lung cancer.
Article
Biochemistry & Molecular Biology
Po-Chao Hsu, Jiun-Chi Huang, Wei-Chung Tsai, Wei-Wen Hung, Wei-An Chang, Ling-Yu Wu, Chao-Yuan Chang, Yi-Chun Tsai, Ya-Ling Hsu
Summary: This study found that serum TNFRSF21 levels were higher in type 2 DM patients with left ventricular hypertrophy (LVH), and were negatively correlated with LV systolic function. TNFRSF21 plays a pathogenic role in heart disease of type 2 DM and can be used as a biomarker of the impairment of cardiac structure and function in type 2 DM patients.
Article
Biochemistry & Molecular Biology
Jiun-Chi Huang, Szu-Chia Chen, Wei-An Chang, Wei-Wen Hung, Ping-Hsun Wu, Ling-Yu Wu, Jer-Ming Chang, Ya-Ling Hsu, Yi-Chun Tsai
Summary: Diabetic nephropathy is a growing threat to human health. This study reveals that high glucose or its metabolites, AGEs, increase the expression and secretion of KITLG in glomerular endothelial cells (GECs), leading to endothelial-to-mesenchymal transition (EndoMT) and increased permeability. Inhibition of KITLG's effects prevents AGE-mediated EndoMT in GECs, suggesting its critical role in GEC injury. KITLG levels are found to be higher in GECs and urine of diabetic mice and type 2 diabetic patients, and are correlated with urinary albumin-to-creatinine ratio and estimated glomerular filtration rate. KITLG may serve as a biomarker for DN progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Tung-Chi Yeh, Chia-Min Chen, Chih-Hung Cheng, Chau-Chyun Sheu, Ming-Ju Tsai, Wei-An Chang
Summary: This study investigates a modified method for reducing malposition in peripherally inserted central catheter placement. The results suggest that this modified method may decrease the incidence of long peripherally inserted central catheter placements among patients in medical intensive care units. However, further evaluation is needed through prospective and larger sample size studies in the future.
SAGE OPEN MEDICINE
(2023)
Article
Oncology
Ya-Ling Hsu, Meng-Chi Yen, Wei-An Chang, Pei-Hsun Tsai, Yi-Chung Pan, Ssu-Hui Liao, Po-Lin Kuo
BREAST CANCER RESEARCH
(2019)