Article
Genetics & Heredity
Narges Maleki, Negar Yavari, Maryam Ebrahimi, Ahmad Faisal Faiz, Roya Khosh Ravesh, Aysan Sharbati, Mohammad Panji, Keivan Lorian, Abdollah Gravand, Mojtaba Abbasi, Omid Abazari, Mehdi Shafiee Mehr, Yasin Eskandari
Summary: Silibinin exhibits strong inhibitory effects on ovarian cancer by suppressing cell viability, migration, and invasion, and promoting apoptosis. It also reverses epithelial-mesenchymal transition mechanism and ameliorates tumor growth.
Article
Anatomy & Morphology
Song Wu, Xiaoqian Li, Junqi Yang, Liu Yang
Summary: The expression of PCDH8 is lower in colorectal cancer, and overexpression of PCDH8 can inhibit the proliferation, migration, and invasion of colorectal cancer cells, as well as induce apoptosis. The mechanism may be related to the regulation of the AKT/GSK313/13-catenin signaling pathway.
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Yang Dong, Wei-ming Ma, Zhen-duo Shi, Zhi-guo Zhang, Jia-he Zhou, Yang Li, Shao-qi Zhang, Kun Pang, Bi-bo Li, Wen-da Zhang, Tao Fan, Guang-yuan Zhu, Liang Xue, Rui Li, Ying Liu, Lin Hao, Cong-hui Han
Summary: Bladder urothelial carcinoma (BC) is a deadly malignancy, and Neuropilin-1 (NRP1) has been found to be highly expressed in BC tissues and cells. Knockdown of NRP1 promotes apoptosis and inhibits proliferation, angiogenesis, migration, and invasion of BC cells, potentially serving as a new therapeutic target for BC treatment. Additionally, NRP1 affects various biological functions through MAPK signaling and cancer pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jin-Nyoung Ho, Jessie Sungyun Jeon, Dan Hyo Kim, Hoyoung Ryu, Sangchul Lee
Summary: CUDC-907 is a novel inhibitor that showed anticancer effects on bladder cancer by inducing apoptosis, inhibiting migration and invasion, and suppressing epithelial-mesenchymal transition. It reduced cell viability and increased apoptosis-related gene expression in bladder cancer spheroids. These findings suggest that CUDC-907 could be a potential treatment for bladder cancer.
Article
Oncology
Shuai Huang, Xudong Zhang, Kai Luo, Li Jiang, Jianhua Jiang, Renfeng Li
Summary: In this study, OSBP2 was found to be highly expressed in PDAC and its upregulation promoted the progression of PDAC, including increased cell migration, invasion, proliferation, chemotherapy resistance, and decreased apoptosis. Furthermore, overexpression of OSBP2 resulted in downregulation of the cell adhesion molecule E-cadherin and upregulation of other transcription factors. Therefore, OSBP2 may serve as a potential diagnostic and therapeutic target for PDAC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao, Demin Chen
Summary: This research identifies the circLONP2/miR-584-5p/YAP1 axis as a novel regulatory module in the progression of bladder cancer. The study shows that circLONP2 plays an oncogenic role by regulating the miR-584-5p/YAP1 axis, and targeting this interaction could be a potential strategy for treating bladder cancer.
Article
Biochemistry & Molecular Biology
Huihui Wang, Hao Zhang, Zhirong Sun, Wankun Chen, Changhong Miao
Summary: The research showed that GABABR1 inhibits the migration and invasion of CRC cells by suppressing EMT and the Hippo/YAP1 pathway, indicating that GABABR1 could be a potential therapeutic target for CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fan Zhang, Hong Wu
Summary: MiR-599 is significantly downregulated in bladder cancer and its overexpression can inhibit the malignancy of BC cells, with TOP2A identified as a downstream target contributing to enhanced tumorigenesis in BC cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Xiong Du, Yanxin Li, Bin Lian, Xiangli Yin
Summary: This study investigated the influence of microRNA-128-3p (miR-128-3p) on gastric cancer (GC) cells by regulating Tuftelin1 (TUFT1). It was found that miR-128-3p expression was low and TUFT1 expression was high in GC tissues. miR-128-3p can inhibit GC cell activities by repressing TUFT1 expression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yih-Shou Hsieh, Shu-Chen Chu, Shih-Chien Huang, Shao-Hsuan Kao, Meng-Shuan Lin, Pei-Ni Chen
Summary: The research showed that gossypol inhibited the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Environmental Sciences
Ruipu Chen, Jing Liu, Jun Hu, Chunxia Li, Yanhua Liu, Weiwei Pan
Summary: DLGAP5 is highly expressed in endometrial cancer (EC) and is associated with poor prognosis. Silencing DLGAP5 inhibits proliferation and invasion of EC cells by inactivating the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Chi-Chiu Lee, Chia-Jui Yu, Sushree Shankar Panda, Kai-Chi Chen, Kang-Hao Liang, Wan-Chen Huang, Yu-Shiuan Wang, Pei-Chin Ho, Han-Chung Wu
Summary: This study explores the interaction between EpCAM and HGFR and its impact on the metastatic and invasive abilities of colon cancer cells. The results demonstrate that EpCAM binds to HGFR and activates the ERK and FAK-AKT signaling pathways, leading to the promotion of colon cancer metastasis. Furthermore, the combined treatment with EpCAM and HGFR antibodies significantly inhibits tumor progression and improves patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Weiyu Wang, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Liujia He, Mingjie Xu, Shiming Chen, Haixiang Shen, Xiangyi Zheng, Ben Liu, Xiao Wang, Liping Xie
Summary: Research shows miR-665's role in regulating SMAD3 and SNAIL genes in bladder cancer, making it a potential therapeutic target.