Article
Environmental Sciences
Seetharam Deepa, Sajwan-Khatri Mamta, Arumugam Anitha, Balasubramanian Senthilkumaran
Summary: This study focused on the effects of single-walled carbon nanotubes (SWCNT) on common carp and found that exposure to SWCNT caused changes in testicular and brain function as well as toxic effects. The study suggests that the discharge of carbon nanotubes poses a greater risk to the aquatic environment.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rossella Daniela Bengalli, Giuseppe Zerbi, Andrea Lucotti, Tiziano Catelani, Paride Mantecca
Summary: The role of structural defects in carbon nanotubes (CNTs) as organic stressors triggering their potential toxicity is investigated. The amount of structural defects is estimated through Raman spectroscopy, and CNTs with more defects are found to induce more oxidative stress, cytotoxicity, and cellular damage.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Monika Sharma, Nikhil Maheshwari, Fahim Halim Khan, Riaz Mahmood
Summary: The extensive use of harmful pesticides in agriculture, including Carbendazim (CBZ), poses serious threats to the environment and human health. CBZ has been found to cause various health problems, including endocrine disruption, embryo toxicity, and neurodegenerative disorders.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Edgardo Cruces, Ana C. Barrios, Yaritza P. Cahue, Brielle Januszewski, Leanne M. Gilbertson, Francois Perreault
Summary: The study compared the toxicity of oxidized multi-walled CNTs and GO in the cyanobacterium Microcystis aeruginosa. The results showed that both CNMs induced indirect toxicity through physical mechanisms associated with light shading and cell aggregation, without causing oxidative stress or membrane damage. This indirect toxicity explained why the intrinsic differences in shape, size, and surface properties between CNTs and GO did not result in differences in how they induce toxicity to cyanobacteria.
Article
Pharmacology & Pharmacy
Priyanka P. Patil, Pranjal Kumar, Pukar Khanal, Vishal S. Patil, Harish R. Darasaguppe, Vishwambhar Vishnu Bhandare, Arati Bhatkande, Sudhanshu Shukla, Rajesh K. Joshi, Basanagouda M. Patil, Subarna Roy
Summary: This study aimed to determine whether the administration of cocoa bean extract can reduce organ damage caused by doxorubicin in mice with Ehrlich ascites carcinoma (EAC) without compromising doxorubicin efficacy. The results showed that cocoa extract (COE) exhibited selective cytotoxicity on cancer cells and enhanced the potency of doxorubicin when used in combination. In addition, COE reduced EAC and doxorubicin-induced toxicities in mice and showed powerful anticancer and antioxidant effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Witkowska, Marta Szukalska, Magdalena Richter, Tomasz Trzeciak, Izabela Miechowicz, Andrzej Marszalek, Wojciech Piekoszewski, Zuzanna Wyrwa, Michael Giersig
Summary: Multi-walled carbon nanotubes (MWCNTs) can be toxic when in contact with the biological system due to their size, causing oxidative stress and the production of reactive oxygen species (ROS). This study evaluated the oxidative stress of MWCNTs in male rats using various parameters. The results showed that higher concentrations of nanotubes led to decreased TEAC levels in the liver, increased NO levels in the kidneys, and lower GSH levels in the serum. Therefore, analyzing oxidative stress parameters can be a key indicator of the toxic potential of MWCNTs.
Article
Environmental Sciences
Long Kong, Guizhen Yan, Xinxin Huang, Yanxin Wu, Xin Che, Jian Liu, Jianbo Jia, Hongyu Zhou, Bing Yan
Summary: The probability of occupational exposure to carbon nanotubes (CNTs) is increasing due to their growing production and biomedical applications. As a result, the risk of co-exposure of nanomaterials with environmental pollutants is also increasing. This study investigated the toxicity of pristine single-walled CNTs (p-SWCNTs) and oxidized single-walled CNTs (SWCNT-COOHs) on cell responses to metal ions (Pb2+, Cu2+, and Cr(VI)). The findings suggest that understanding the effects of the exposure sequence of engineered nanomaterials and environmental pollutants on their toxicity is crucial for evaluating combined toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Vaniyamparambath Vijayalakshmi, Bindu Sadanandan, Raghu V. V. Anjanapura
Summary: In this study, the toxicity of multiwalled carbon nanotubes (MWCNTs) and carboxylic functionalized MWCNTs (MWCNT-COOH) on neuronal cells was compared. The results showed that MWCNT-COOH had higher cell viability and lower oxidative stress compared to MWCNT at higher concentrations and longer incubation periods.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sonia Martel Martin, Rocio Barros, Brixhilda Domi, Carlos Rumbo, Matteo Poddighe, Santiago Aparicio, Maria Suarez-Diez, Juan Antonio Tamayo-Ramos
Summary: This study assessed the toxicity of commercial pristine multi-walled carbon nanotubes on Saccharomyces cerevisiae and found that cell proliferation was negatively affected at a high concentration of 800 mg L-1, while oxidative stress was induced at a lower concentration of 160 mg L-1. The transcriptome analysis showed limited biological response of the yeast cells exposed to the selected MWCNTs, with only a small number of genes showing significant transcriptional changes, most of which were downregulated.
Article
Pharmacology & Pharmacy
Katsuhide Fujita, Sawae Obara, Junko Maru
Summary: This study investigated the toxicity of submicron-diameter carbon fibers (SCFs) with different diameters and lengths on the lungs and cells. The results showed that the diameter and length of SCFs were associated with their pulmonary toxicity and cytotoxicity. Additionally, the SCFs did not induce genotoxicity. These findings provide new evidence for evaluating the potential toxicity of SCFs with different manufacturing processes or physicochemical properties.
Article
Marine & Freshwater Biology
Mingxing Wang, Huiyun Wang, Guoliang Chen, Juan Liu, Tingzhang Hu
Summary: In this study, the toxicological effects of Spiromesifen on zebrafish embryos were investigated. The results showed that Spiromesifen induced cytotoxicity and developmental toxicity in zebrafish embryos. The potential mechanism seemed to be related to oxidative stress and changes in apoptosis, immune, and antioxidant-related markers. The inflammatory response and antioxidant system participated in and resisted the threat of Spiromesifen to prevent tissue damage.
AQUATIC TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Joyita Roy, Kunal Roy
Summary: Nanotechnology is a promising area of research, and understanding the behavior of nanomaterials in biological systems is crucial. QSAR models are widely adopted to predict the toxicity of untested nanomaterials, and in this study, they were used to evaluate the cytotoxicity of MeOx NPs towards RAW 264.7 cells. Insights from the models suggest that factors such as electronegativity, solubility, and the formation of metal cations influence cytotoxicity levels.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Multidisciplinary Sciences
Carlos Rumbo, Cristina Cancho Espina, Juergen Gassmann, Olivier Tosoni, Rocio Barros Garcia, Sonia Martel Martin, Juan Antonio Tamayo-Ramos
Summary: The newly developed NdFeTi and NdFeSi alloys showed comparable toxicological potential to a commercial NdFeB alloy in in vitro assays, with harmful effects only resulting from direct interaction with alloy particulates.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Nalinee Kanth Kadiyala, Badal Kumar Mandal, L. Vinod Kumar Reddy, Crispin H. W. Barnes, Luis De Los Santos Valladares, Dwaipayan Sen
Summary: This study presents a one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed ZrO2/rGO nanocrystals using the aqueous leaf extract of Andrographis paniculata. The synthesized nanocrystals exhibited dose-dependent cytotoxicity on human cancer cell lines (A549 and HCT116) and had the ability to induce apoptosis. The green synthesis of ZrO2/rGO nanocrystals shows potential in developing efficient therapeutic agents for cancer therapy.
Article
Environmental Sciences
Minling Gao, Yalei Xu, Xipeng Chang, Zhengguo Song
Summary: The detailed study of nanomaterials has revealed their broad application prospects, but the presence of carbon nanotubes combined with heavy metals may pose toxicity to crops. This study investigated the effects of Cd on wheat seedlings' photosynthetic capacity and antioxidant activity in the presence of single-walled and multi-walled carbon nanotubes. The results showed that the combined presence of carbon nanotubes and Cd significantly increased the oxidative stress response in wheat seedlings and led to negative impacts on their physiological processes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
