Article
Pharmacology & Pharmacy
Rongheng Liao, Zhen Qi, Ri Tang, Renrong Wang, Yongyi Wang
Summary: The study revealed that MFA can alleviate fibrosis-related proteins expression, migration, and proliferation ability in human cardiac fibroblasts induced by TGF-beta 1, and improve fibrosis area, cardiac function, and fibrosis-related proteins expression in myocardial infarction mouse models. The mechanism involves MFA suppressing HCF differentiation by inhibiting migration and proliferation, through the pRB-E2F1/CCNE2 and the RhoA/ROCK2 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Medicine, Research & Experimental
Danh C. Do, Yan Zhang, Wei Tu, Xinyue Hu, Xiaojun Xiao, Jingsi Chen, Haiping Hao, Zhigang Liu, Jing Li, Shau-Ku Huang, Mei Wan, Peisong Gao
Summary: The study reveals a RhoA/SLC26A4 axis in AT2 cells functioning as a protective mechanism against allergic airway inflammation.
Article
Biochemistry & Molecular Biology
Katarzyna Sobierajska, Marta E. Wawro, Jolanta Niewiarowska
Summary: Oxidative stress enhances mesenchymal trans-differentiation of human microvascular endothelial cells through the TGF-beta 2-RhoA/Rac1-MRTF-A axis, providing a potential therapeutic target for fibrotic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dandan Peng, Minyang Fu, Manni Wang, Yuquan Wei, Xiawei Wei
Summary: TGF-beta plays essential roles in early embryonic development, organogenesis, immune regulation, tissue repair, and adult homeostasis. Its involvement in fibrosis and cancer is complex and context-dependent, showing both inhibitory and promoting effects. Therapeutics targeting TGF-beta signaling hold promise in treating fibrosis and cancer, although the development is hindered by potential systemic cytotoxicity.
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Article
Oncology
Michael-John Devilin, Rowan Miller, Florian Laforets, Panoraia Kotantaki, Dale W. Garsed, Rebecca Kristeleit, David D. Bowtell, Jacqueline McDermott, Eleni Maniati, Frances R. Balkwill
Summary: The tumor microenvironment (TME) of clear-cell ovarian cancer (CCOC) was analyzed in this study, revealing differences in immune cell populations, collagen matrix, and cytokine expression between different areas of the tumor. Advanced CCOC showed increased fibroblasts and a more complex collagen matrix compared to early CCOC. Differences in immune cell populations, collagen matrix, and cytokine expression were also observed between different genetic subtypes of CCOC. Increased infiltration of specific T cell subpopulations was associated with decreased overall survival.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Xiao Wei, Hua Lou, Dongchen Zhou, Yijuan Jia, Huayi Li, Quanfu Huang, Jingjing Ma, Zongyuan Yang, Chaoyang Sun, Yunchong Meng, Sen Xu, Xin Yang, Xiaoting Li, Teng Ji, Zhongzhen Guo, Qinglei Gao
Summary: This study confirmed that omental metastases in OC are stiffer and more abundant than primary tumors, and matrix stiffness can regulate OC progression. TAGLN was identified as a potent mechanosensitive gene that mediates stiffness-regulated OC progression through RhoA/ROCK pathway. Targeting ECM stiffness and TAGLN may provide promising therapeutic value for OC therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Min Soon Cho, Hani Lee, Ricardo Gonzalez-Delgado, Dan Li, Tomoyuki Sasano, Wendolyn Carlos-Alcalde, Qing Ma, Jinsong Liu, Anil K. Sood, Vahid Afshar-Kharghan
Summary: One-third of ovarian cancer patients have elevated platelet counts associated with poor prognosis. Platelets increase the expression of immune checkpoint (PD-L1) on ovarian cancer cells through contact-dependent and contact-independent pathways. The interaction between platelets and cancer cells enhances tumor growth and dampens the antitumor immune response.
Article
Oncology
Yahui Jiang, Tianyu Zhou, Yiwen Shi, Weiwei Feng, Tianjiao Lyu
Summary: SMYD3 and ITGB6 activate the TGF beta 1/Smad3 pathway to promote the upregulation of N-cadherin, Snail, and Vimentin and the downregulation of E-cadherin in ovarian cancer spheroids. This positive feedback loop further amplifies the biological effects and promotes invasion and adhesion of ovarian cancer spheroids.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig
Summary: The study found that the GTPase RhoA and its downstream targets, ROCK1 and ROCK2, play important roles in neuroinflammation. The use of specific inhibitors can alleviate the inflammatory response induced by lipopolysaccharide (LPS) by blocking NF-κB nuclear translocation and neuroinflammatory gene transcription. Further experiments demonstrated that RhoA activation exacerbates the inflammatory response. The study also revealed that genes in the RhoA/ROCK signaling cascade are highly upregulated in microglia from Alzheimer's disease mice.
Article
Biochemistry & Molecular Biology
Aparna Cherukunnath, Ravichandra S. Davargaon, Rahail Ashraf, Urja Kamdar, Amit K. Srivastava, Prem P. Tripathi, Nabanita Chatterjee, Sanjay Kumar
Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Reproductive Biology
Boqun Liu, Qiongqiong Jia, In-Sun Hong, Xuan Dang, Ze Wu, Hailong Wang, Jung-Chien Cheng, Lanlan Fang
Summary: Levels of transforming growth factor-beta (TGF-beta) isoforms are upregulated in ovarian hyperstimulation syndrome (OHSS) patients, potentially contributing to OHSS development by downregulating steroidogenic acute regulatory protein (StAR) expression. This study suggests that follicular fluid levels of TGF-beta 1 and 3 could serve as biomarkers and therapeutic targets for OHSS.
BIOLOGY OF REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Ashley R. Rackow, David J. Nagel, Gregory Zapas, Ryan S. Clough, Patricia J. Sime, R. Matthew Kottmann
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a poor prognosis. This study investigates the biochemical differences between fibrotic and healthy lung tissue and discovers the upregulation of lactate and the decline in tissue pH in IPF. It also identifies TDAG8 as a proton sensing GPCR that is upregulated in IPF fibroblasts and plays a role in myofibroblast differentiation. Additionally, the study uncovers the inhibitory effect of BTB on myofibroblast differentiation through the suppression of RhoA-mediated signaling. These findings highlight the therapeutic potential of BTB and the importance of RhoA-mediated signaling in the context of myofibroblast differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.