Journal
ONCOLOGY
Volume 88, Issue 4, Pages 214-225Publisher
KARGER
DOI: 10.1159/000368556
Keywords
Breast cancer; Carcinoma-associated fibroblasts; Cell proliferation; Cell-to-cell interaction; Mesenchymal stromal cells
Categories
Funding
- Finnish Medical Foundation
- Academy of Finland
- Thelma Makikyro Foundation
- Oulu University Hospital
Ask authors/readers for more resources
The interplay between tumor stroma and breast cancer cells (BCCs) is thought to play a significant role in breast cancer. The current knowledge of human mesenchymal stromal cell (MSC) and BCC interaction is contradictory, and the donor sex issue is not addressed at all. We hypothesized that donor sex could have an effect on proliferation of MSCs or BCCs in co-culture in vitro. Three estrogen receptor-negative BCC lines, 19 primary human MSCs and breast tissue-derived fibroblasts from 4 donors were used. MSCs from female donors enhanced BCC proliferation (p = 0.005). The change in BCC proliferation was only partly due to soluble factors excreted by MSCs. The highly aggressive BCC line MDA-MB-231 induced the proliferation of MSCs (p < 0.001) and fibroblasts (p = 0.037) in co-culture experiments. The magnitude in proliferation change was cell line dependent and partly sex dependent. (C) 2014 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available