Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 11, Pages 2309-2312Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20092160
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A key feature of aggressive B cell lymphomas is constitutive NF-kappa B activation, which requires signals from the CARD11-BCL-10-MALT1 (CMB) complex. The unique enzymatic activity of MALT1 degrades one of its binding partners, BCL-10, as well as the NF-kappa B inhibitor A20. New data shows that targeting MALT1 protease activity may be a promising therapeutic strategy for treating aggressive B cell lymphomas.
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