The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

(2015) Marie Loosveld et al.   Oncotarget

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models

(2015) Yukihiko Hiroshima et al.   Oncotarget

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma

(2014) S. E. Trabucco et al.   CLINICAL CANCER RESEARCH

Efficacy ofSalmonella typhimuriumA1-R Versus Chemotherapy on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX)

(2014) Yukihiko Hiroshima et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen

(2014) V. Sahai et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

(2014) Trent Fowler et al.   PLoS One

Metastatic Recurrence in a Pancreatic Cancer Patient Derived Orthotopic Xenograft (PDOX) Nude Mouse Model Is Inhibited by Neoadjuvant Chemotherapy in Combination with Fluorescence-Guided Surgery with an Anti-CA 19-9-Conjugated Fluorophore

(2014) Yukihiko Hiroshima et al.   PLoS One

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer

(2013) W.-c. Lin et al.   CANCER RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non-Small Cell Lung Cancer

(2013) T. Shimamura et al.   CLINICAL CANCER RESEARCH

Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

(2013) Z. Cheng et al.   CLINICAL CANCER RESEARCH

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation

(2013) S. Chandra et al.   JOURNAL OF CELL SCIENCE

Development and Histopathological Characterization of Tumorgraft Models of Pancreatic Ductal Adenocarcinoma

(2013) Patrick L. Garcia et al.   PLoS One

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

(2013) D Da Costa et al.   Blood Cancer Journal

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

Knockdown of Cdc25B in Renal Cell Carcinoma is Associated with Decreased Malignant Features

(2012) Xiu-Yue Yu et al.   Asian Pacific Journal of Cancer Prevention

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

(2012) C. J. Ott et al.   BLOOD

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells

(2012) W.-J. Wang et al.   CANCER RESEARCH

Small-Molecule Inhibition of BRDT for Male Contraception

(2012) Martin M. Matzuk et al.   CELL

Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens

(2012) Atsushi Suetsugu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

(2012) W. W. Lockwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

(2011) Yinghua Chen et al.   BMC CANCER

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Myc is a downstream target of RET signaling and is required for transcriptional regulation of p18Ink4c by the transforming mutant RETC634R

(2010) Mandar V. Kulkarni et al.   Molecular Oncology

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

(2010) Lina Guerra et al.   PLoS One

Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages

(2010) Sonja Gillen et al.   PLOS MEDICINE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE