Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling

Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts

(2014) K.-W. Lee et al.   CANCER RESEARCH

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

(2014) Kepeng Wang et al.   IMMUNITY

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

(2014) Jeeyun Lee et al.   PLoS One

Anti-EGFR and anti-VEGF agents: Important targeted therapies of colorectal liver metastases

(2014) Qing-Yang Feng   WORLD JOURNAL OF GASTROENTEROLOGY

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment

(2013) H. Reuveni et al.   CANCER RESEARCH

CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils

(2013) Shao-Lai Zhou et al.   CARCINOGENESIS

A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute toHelicobacter pylori-associated human gastric tumorigenesis

(2013) Hua Xiong et al.   INTERNATIONAL JOURNAL OF CANCER

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Genetic Variants, Prediagnostic Circulating Levels of Insulin-like Growth Factors, Insulin, and Glucose and the Risk of Colorectal Cancer: The Multiethnic Cohort Study

(2012) N. J. Ollberding et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Correlation between Gene Expression of IGF-1R Pathway Markers and Cetuximab Benefit in Metastatic Colorectal Cancer

(2012) F. Huang et al.   CLINICAL CANCER RESEARCH

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

The Insulin Receptor Substrate 1 (Irs1) in Intestinal Epithelial Differentiation and in Colorectal Cancer

(2012) Diana L. Esposito et al.   PLoS One

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Angiogenesis in cancer

(2011) G. W. Prager et al.   Hamostaseologie

Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps

(2011) Adelheid Soubry et al.   INTERNATIONAL JOURNAL OF CANCER

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR

(2011) A Rojas et al.   ONCOGENE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Ikappa B kinaseβ/nuclear factor-κB activation controls the development of liver metastasis by way of interleukin-6 expression

(2009) Shin Maeda et al.   HEPATOLOGY

Increased invasion through basement membrane by CXCL7-transfected breast cells

(2008) Zhuo Tang et al.   AMERICAN JOURNAL OF SURGERY

Insulin Receptor Substrates (IRSs) and Breast Tumorigenesis

(2008) Bonita Tak-Yee Chan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer

(2008) P. D. Ryan et al.   ONCOLOGIST

Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+Tumors, and Regulates Sox9

(2007) Nicole M. Ramocki et al.   ENDOCRINOLOGY