Article
Biochemistry & Molecular Biology
Yawei Shen, Huiyang Li, Jinliang Zhao, Shoujie Tang, Yan Zhao, Yifeng Gu, Xiaowu Chen
Summary: This study cloned the full-length sequences of multiple aqp genes in Siniperca chuatsi and found differential gene expression in different tissues. Following salt treatment, the expression levels of some aqp genes significantly changed. Realtime quantitative PCR analysis demonstrated significant alterations in gene expression levels in the intestines.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Plant Sciences
Jia Yun Sun, Xue Son Liu, Irfan Ullah Khan, Xi Chen Wu, Zhi Min Yang
Summary: The study identified an uncharacterized aquaporin gene OsPIP2;3 involved in rice water deficit and salt stress responses, enhancing plant growth and physiological adaptations under water deficit.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Jonathan Yde, Stephen J. Keely, Hanne B. Moeller
Summary: AQP3 is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Although altered in several intestinal disorders, the regulation and specific roles of AQP3 remain to be fully defined. This mini-review summarizes the current understanding of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Environmental Sciences
Zhongkai Wang, Yigeng Chen, Cong Wang, Nannan Zhao, Zhihao Zhang, Zhitong Deng, Yanting Cui, Renjie Wang, Yuquan Li
Summary: This study identified and characterized three types of AQPs in Litopenaeus vannamei and investigated their potential roles in osmoregulation. The expression levels of AQPs were significantly decreased under salinity stress, though the patterns varied among isoforms and tissues. Comparative transcriptome analysis revealed the involvement of aquaglyceroporin and amino acid metabolism related genes and pathways in the response to acute salinity changes in the intestine.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Plant Sciences
Yeon Mi Lee, Geun Young Chae, Min Kyung Kim, Seungill Kim
Summary: This study conducted a comprehensive genomic study of AQPs in pepper, identifying a large proportion of AQP genes belonging to the TIP4 subfamily and analyzing their chromosomal localization and duplication times. Transcriptome analysis revealed that transport-, photosystem-, and thylakoid-related genes were generally enriched in expression clusters containing AQP genes in pepper.
Review
Biochemistry & Molecular Biology
Marcelo Ozu, Juan Jose Alvear-Arias, Miguel Fernandez, Agustin Caviglia, Antonio Pena-Pichicoi, Christian Carrillo, Emerson Carmona, Anselmo Otero-Gonzalez, Jose Antonio Garate, Gabriela Amodeo, Carlos Gonzalez
Summary: AQPs are small transmembrane tetrameric proteins that facilitate water, solute and gas exchange. Their ability to modulate water membrane permeability in response to specific regulators has been experimentally demonstrated. Studies have shown that the repositioning of conserved residues contributes to restricting water permeation in the channel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guzel Sharipova, Ruslan Ivanov, Dmitriy Veselov, Guzel Akhiyarova, Oksana Seldimirova, Ilshat Galin, Wieland Fricke, Lidiya Vysotskaya, Guzel Kudoyarova
Summary: Stomatal closure in salt-stressed plants is related to the reduction of aquaporin abundance and hydraulic conductivity, leading to decreased transpiration and ABA accumulation. Exogenous ABA, on the other hand, decreases transpiration but increases shoot hydraulic conductivity and aquaporin abundance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cui Zhu, Xilong Li, Fuller W. Bazer, Gregory A. Johnson, Robert C. Burghardt, Zongyong Jiang, Guoyao Wu
Summary: This study found that dietary supplementation of L-arginine in pregnant gilts increased the expression of water channel proteins in their placentae and endometria, enhancing water transport from mother to fetus.
Article
Plant Sciences
Shina Sasi, Sajeesh Kappachery, Jelli Venkatesh, Ritesh Ghosh, Mayank Anand Gururani
Summary: Plants expressing the potato PIP2-7 gene showed improved tolerance to osmotic stress, with higher chlorophyll content, improved stomatal conductance, less electrolyte leakage, and lower malondialdehyde accumulation. PIP plants also exhibited increased expression of antioxidant enzymes and stress-response genes, and had enhanced photochemical efficiency and photosynthetic activity compared to wild type plants. These findings suggest that PIP may be beneficial for developing stress-tolerant crops in the future.
PLANT GROWTH REGULATION
(2023)
Article
Biochemistry & Molecular Biology
Hooman Hadidi, Reza Kamali
Summary: In this study, non-equilibrium molecular dynamics simulations were used to investigate the effects of external electric fields on the gating mechanism and water permeability of human aquaporin-2 (AQP2). The results showed that different directions of the electric field can lead to varied conformations of the selectivity filter region in AQP2, affecting water molecule translocation and permeability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Quanquan Cao, Eva Blondeau-Bidet, Catherine Lorin-Nebel
Summary: European sea bass migrate to habitats with high salinity levels and show different physiological responses to hypersaline conditions among different lineages, suggesting slight physiological differences between populations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Physiology
Kevin L. Schey, Romell B. Gletten, Carla V. T. O'Neale, Zhen Wang, Rosica S. Petrova, Paul J. Donaldson
Summary: This article discusses the structure and function of lens AQPs, their impact on water flow, and provides a detailed explanation of age-related changes and their effects on the lens. The article suggests that AQPs could be potential therapeutic targets for the prevention or treatment of cataract and presbyopia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Jiaqi Bai, Xuan Wang, Xiaohui Yao, Xiaochen Chen, Kai Lu, Yiqun Hu, Zuodong Wang, Yanjie Mu, Liyuan Zhang, Hansong Dong
Summary: This study identified OsPIP2;2 as the most efficient facilitator of H2O transport in rice, with its overexpression enhancing drought tolerance and promoting H2O transport and drought-related physiological responses.
Article
Plant Sciences
Hanchen Tang, Qing Yu, Zhu Li, Feng Liu, Weihua Su, Chang Zhang, Hui Ling, Jun Luo, Yachun Su, Youxiong Que
Summary: This study identified the role of the ScPIP2-1 gene in response to salt stress in sugarcane, demonstrating its positive effects on plant adaptation through regulation of stress hormones and ion balance. The overexpression of ScPIP2-1 in Arabidopsis thaliana resulted in enhanced salt tolerance at phenotypic, physiological, and molecular levels.
Article
Plant Sciences
Sarah Tepler Drobnitch, Louise H. Comas, Nora Flynn, Jorge Ibarra Caballero, Ryan W. Barton, Joshua Wenz, Taylor Person, Julie Bushey, Courtney E. Jahn, Sean M. Gleason
Summary: Root pressure is a mechanism that increases crop production under drought conditions, possibly related to root allocation and gene regulation. In six genotypes of Sorghum bicolor, root pressure promotes adaptation by regulating the ratio of fine: coarse root length and shoot biomass production. Using RNA-Seq, genes for aquaporins, membrane transporters, and ATPases were identified as potential regulators of positive xylem pressure in root tissue.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Environmental Sciences
Fatemeh F. Masouleh, Bagher M. Amiri, Alireza Mirvaghefi, Hossein Ghafoori, Steffen S. Madsen
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2017)
Article
Physiology
Lucie Gerber, Frank B. Jensen, Steffen S. Madsen
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Article
Physiology
Ana T. Silva, Jonathan D. Midwood, Kim Aarestrup, Tom G. Pottinger, Steffen S. Madsen, Steven J. Cooke
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2018)
Article
Cell Biology
Laura Ellis, Rebecca J. Bollinger, Hannah M. Weber, Steffen S. Madsen, Christian K. Tipsmark
Article
Ecology
Steffen S. Madsen, Sara S. T. Winther, Rebecca J. Bollinger, Ulrich Steiner, Martin H. Larsen
ECOLOGY AND EVOLUTION
(2019)
Review
Oncology
Joanna Katarzyna Bujak, Dania Kosmala, Wane Monika Szopa, Kinga Majchrzak, Piotr Bednarczyk
FRONTIERS IN ONCOLOGY
(2019)
Article
Zoology
M. Hertz, L. F. Jensen, C. Pertoldi, K. Aarestrup, S. N. Thomsen, A. K. O. Alstrup, H. Asmus, S. S. Madsen, J. C. Svendsen
CANADIAN JOURNAL OF ZOOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Christian K. Tipsmark, Andreas M. Nielsen, Maryline C. Bossus, Laura V. Ellis, Christina Baun, Thomas L. Andersen, Jes Dreier, Jonathan R. Brewer, Steffen S. Madsen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Joanna K. Bujak, Iwona M. Szopa, Rafal Pingwara, Olga Kruczyk, Natalia Krzeminska, Joanna Mucha, Kinga Majchrzak-Kuligowska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Iwona Monika Szopa, Monika Granica, Joanna Katarzyna Bujak, Agata Labedz, Maciej Blaszczyk, Chrystal Mary Paulos, Kinga Majchrzak-Kuligowska
Summary: Activation of canine PBLs via MicroBeads induces cluster formation and expression of activation marker CD25 within 24 hours, demonstrating the lower activation signal strength needed for efficient proliferation and expansion in canine PBLs. Both 37 degrees C and 38.5 degrees C were found to be optimal for expanding canine T cells, and MicroBeads supported the propagation of T cells with an effector memory phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joanna K. Bujak, Daria Kosmala, Kinga Majchrzak-Kuligowska, Piotr Bednarczyk
Summary: The study confirmed the expression of the TRPV1 ion channel on both mRNA and protein levels in canine PBMC, and indicated that the ion channel is functional.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Nina G. Walker Hansen, Steffen S. Madsen, Melanie Brauckhoff, Rachael M. Heuer, Lela S. Schlenker, Morten B. Engelund, Martin Grosell
Summary: Gulf toadfish with aglomerular kidney can survive in various salinities including high Mg2+ environments. The study found that transcriptional regulation of renal Mg2+ transporters is influenced by a combination of elevated Mg2+ levels and salinity, rather than high Mg2+ levels alone.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Joanna Bujak, Stanislaw Klek, Martyna Balawejder, Aleksandra Kociniak, Kinga Wilkus, Rafal Szatanek, Zofia Orzeszko, Joanna Welanyk, Grzegorz Torbicz, Mateusz Jeckowski, Tomasz Kucharczyk, Lukasz Wohadlo, Maciej Borys, Honorata Stadnik, Michal Wysocki, Magdalena Kayser, Marta Ewa Slomka, Anna Kosmowska, Karolina Horbacka, Tomasz Gach, Beata Markowska, Tomasz Kowalczyk, Jacek Karon, Marek Karczewski, Miroslaw Szura, Anna Sanecka-Duin, Agnieszka Blum
Summary: This study aims to collect patient samples and generate a database of pHLA:TCR sequences to aid the development of an AI-based platform for efficient selection of specific TCRs, which can improve the treatment outcomes for colorectal cancer patients.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Physiology
Steffen S. Madsen, Rebecca J. Bollinger, Melanie Brauckhoff, Morten Buch Engelund
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Review
Veterinary Sciences
Joanna Katarzyna Bujak, Rafal Pingwara, Michelle Hase Nelson, Kinga Majchrzak
ACTA VETERINARIA SCANDINAVICA
(2018)