Article
Oncology
Bai-Hui Liu, Gong-Bao Liu, Bin-Bin Zhang, Jian Shen, Lu-Lu Xie, Xiang-Qi Liu, Wei Yao, Rui Dong, Yun-Li Bi, Kui-Ran Dong
Summary: This study identified seven novel gene mutations in wilms tumor, with MUC6 being the most prevalent mutation. MUC6 acts as a tumor suppressive gene through autophagy dependent beta-catenin pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada
Summary: The study explores the unique mechanisms of cholesterol metabolism in naked mole-rat cells, which may contribute to their anti-senescent properties and longevity. Beta-catenin is identified as a key player in regulating cholesterol metabolism to offset senescence in naked mole-rats.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Weihao Lin, Xin Wang, Zhen Wang, Fei Shao, Yannan Yang, Zheng Cao, Xiaoli Feng, Yibo Gao, Jie He
Summary: Cellular senescence plays a crucial role in tumorigenesis, development, and immune modulation in lung adenocarcinoma (LUAD). A cellular senescence-related signature (SRS) was identified as an independent prognostic predictor for LUAD patients, showing potential value in predicting clinical outcomes and immunotherapy response. High SRS scores correlated with senescence-associated secretory phenotype (SASP) and an immunosuppressive phenotype, highlighting SRS as a robust biomarker for immunotherapeutic response and prognosis in LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Joseph H. Lucas, Qixin Wang, Thivanka Muthumalage, Irfan Rahman
Summary: The study found that exposure to MWCNTs can lead to cellular senescence in human bronchial epithelial cells, with increased production of reactive oxygen species and inhibition of cell proliferation. Co-exposure with the cytokine TGF-beta further exacerbated cellular senescence, as indicated by increased levels of related proteins and significantly elevated production of fibronectin and plasminogen activator inhibitor.
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tanyalak Parimon, Miriam S. Hohmann, Changfu Yao
Summary: Pulmonary fibrosis is a chronic and fatal lung disease that predominantly affects the aging population globally. Understanding the mechanisms of cellular senescence may offer new pathways for treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Weihao Lin, Xin Wang, Zhenyi Xu, Zhen Wang, Tiejun Liu, Zheng Cao, Xiaoli Feng, Yibo Gao, Jie He
Summary: This study identified three cellular senescence clusters in LUAD patients and established a cellular senescence-related scoring system (CSS) as an independent prognostic factor and immunotherapy predictor. Patients with low CSS showed prolonged survival time and increased response to anti-cancer drugs and immunotherapy. The findings enhance the understanding of the tumor immune microenvironment in LUAD and provide new insights for improving immunotherapy outcomes for patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Cong Xie, Mai Maititusun Ya Likun, Qing-li Luo, Jing-cheng Dong
Summary: Cellular senescence, characterized by permanent cell proliferation arrest, plays a crucial role in the development of cancer and age-related illnesses. This study reviews the recent progress on cellular senescence and its impact on lung inflammation, providing insights into the underlying mechanisms and clinical relevance. The study also proposes the importance of controlling cellular senescence and pro-inflammatory response activation in order to attenuate inflammatory lung conditions and improve disease outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran
Summary: TGF-0 induces senescence in the tumor microenvironment, leading to a suppressive immune phenotype. Inhibiting TGF-0 signaling reduces senescent cells and the secretion of 14-gene SASP, enhancing immune infiltration. Patients with high expression of the 14-gene SASP display immunosuppression in response to immune therapy.
Article
Pharmacology & Pharmacy
Yi-Xin Chen, Chen-Jing Wang, De-Sheng Xiao, Bai-Mei He, Min Li, Xiao-Ping Yi, Wei Zhang, Ji-Ye Yin, Zhao-Qian Liu
Summary: This study identified a potential association between the eIF3A R803K somatic mutation and acquired chemotherapy resistance in SCLC patients. Further investigations revealed that this mutation increases chemotherapy resistance by inducing cellular senescence. Additionally, the senolytic drug fisetin showed a synergistic effect with chemotherapy in cells carrying the eIF3A R803K mutation, reversing chemotherapy resistance.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Virology
Sanying Wang, Xuqiang Zhou, Xinyue He, Shushu Ma, Chuan Sun, Jing Zhang, Xiaogang Xu, Weihua Jin, Jin Yan, Ping Lin, Genxiang Mao
Summary: In this study, pterostilbene was found to effectively inhibit the replication of HCMV virus. It acts by suppressing the expression of viral proteins, reducing the replication of viral DNA, and decreasing the viral titer in cells. Furthermore, pterostilbene can also prevent cellular senescence induced by HCMV infection.
Article
Immunology
Jiaxiong Tan, Chaoyu Wang, Yan Jin, Yuren Xia, Baocheng Gong, Qiang Zhao
Summary: The study found that a signature constructed with six genes can better predict the prognosis of neuroblastoma and evaluate the immunosuppressed and aging tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Blake L. Torrance, Laura Haynes
Summary: Aging increases the risk of adverse outcomes following respiratory infections in older adults. Cellular senescence plays a crucial role in disrupting lung function and diminishing the ability to protect against pathogens. However, most vaccines do not effectively confer protection against respiratory infections in older adults.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Luise Schulz, Franziska Hornung, Antje Haeder, Lukas Radosa, Axel A. Brakhage, Bettina Loeffler, Stefanie Deinhardt-Emmer
Summary: Aging is a significant risk factor for respiratory infections and this study investigated the role of influenza virus infections in premature cellular senescence and macrophage-activated inflammation. The researchers observed premature aging and the presence of senescent cells in mouse lungs after 21 days of influenza A virus infection. By using ex vivo lung models, they found that the presence of TNF-alpha contributed to cellular senescence. The study also showed the influence of infected macrophages on lung fibroblasts, confirming the expression of senescence-associated parameters. Additionally, senescent cells in the lungs had a higher viral load, indicating increased viral replication.
Article
Urology & Nephrology
Michael J. Coady, Abdulah El Tarazi, Rene Santer, Pierre Bissonnette, Louis J. Sasseville, Joaquim Calado, Yoann Lussier, Christopher Dumayne, Daniel G. Bichet, Jean-Yves Lapointe
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Computer Science, Information Systems
Vincent Gardeux, Joanne Berghout, Ikbel Achour, A. Grant Schissler, Qike Li, Colleen Kenost, Jianrong Li, Yuan Shang, Anthony Bosco, Donald Saner, Marilyn J. Halonen, Daniel J. Jackson, Haiquan Li, Fernando D. Martinez, Yves A. Lussier
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2017)
Article
Health Care Sciences & Services
A. Grant Schissler, Walter W. Piegorsch, Yves A. Lussier
STATISTICAL METHODS IN MEDICAL RESEARCH
(2018)
Article
Health Care Sciences & Services
Jung-wei Fan, Jianrong Li, Yves A. Lussier
JOURNAL OF HEALTHCARE ENGINEERING
(2017)
Article
Multidisciplinary Sciences
Tong Zhou, Nancy Casanova, Nima Pouladi, Ting Wang, Yves Lussier, Kenneth S. Knox, Joe G. N. Garcia
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Samir Rachid Zaim, Colleen Kenost, Joanne Berghout, Wesley Chiu, Liam Wilson, Hao Helen Zhang, Yves A. Lussier
BMC BIOINFORMATICS
(2020)
Article
Biochemical Research Methods
Dillon Aberasturi, Nima Pouladi, Samir Rachid Zaim, Colleen Kenost, Joanne Berghout, Walter W. Piegorsch, Yves A. Lussier
Summary: The study proposes a new method, Inter-N-of-1, to identify meaningful differences between very small cohorts by using the effect size of 'single-subject-study'-derived responsive biological mechanisms. In both simulations and a clinical proof-of-concept dataset, Inter-N-of-1 showed high precision and recall in cohorts of 3 versus 3 distinct subjects, outperforming conventional methods at smaller sample sizes but being outperformed at larger sample sizes.
Article
Health Care Sciences & Services
Haiquan Li, Edwin Baldwin, Xiang Zhang, Colleen Kenost, Wenting Luo, Elizabeth A. Calhoun, Lingling An, Charles L. Bennett, Yves A. Lussier
Summary: This study analyzed the risk of fatality for cancer patients with COVID-19, controlling for covariates such as age, sex, metastasis status, and cancer type. Results showed an overall HR of fatality of 7.76, with varying levels of risk among different cancer types. The study emphasizes the importance of prompt vaccination for uninfected cancer patients, especially for those most affected by COVID-19.
BMJ HEALTH & CARE INFORMATICS
(2021)
Article
Biochemical Research Methods
Francesca Vitali, Qike Li, A. Grant Schissler, Joanne Berghout, Colleen Kenost, Yves A. Lussier
BRIEFINGS IN BIOINFORMATICS
(2019)
Article
Chemistry, Medicinal
Francesca Vitali, Simone Marini, Martina Balli, Hanne Grosemans, Maurilio Sampaolesi, Yves A. Lussier, Maria Gabriella Cusella De Angelis, Riccardo Bellazzi
Article
Genetics & Heredity
Qike Li, A. Grant Schissler, Vincent Gardeux, Ikbel Achour, Colleen Kenost, Joanne Berghout, Haiquan Li, Hao Helen Zhang, Yves A. Lussier
BMC MEDICAL GENOMICS
(2017)
Article
Critical Care Medicine
Yong Huang, Shwu-Fan Ma, Milena S. Espindola, Rekha Vij, Justin M. Oldham, Gary B. Huffnagle, John R. Erb-Downward, Kevin R. Flaherty, Beth B. Moore, Eric S. White, Tong Zhou, Jianrong Li, Yves A. Lussier, MeiLan K. Han, Naftali Kaminski, Joe G. N. Garcia, Cory M. Hogaboam, Fernando J. Martinez, Imre Noth
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Hematology
Ankit A. Desai, Zhengdeng Lei, Neil Bahroos, Mark Maienschein-Cline, Santosh L. Saraf, Xu Zhang, Binal N. Shah, Seyed M. Nouraie, Taimur Abbasi, Amit R. Patel, Roberto M. Lang, Yves Lussier, Joe G. N. Garcia, Victor R. Gordeuk, Roberto F. Machado
Meeting Abstract
Critical Care Medicine
C. Bime, N. Pouladi, K. Batai, T. Zhou, C. Kempf, X. Sun, S. Sammani, T. Wang, R. Kittles, Y. Lussier, J. G. N. Garcia
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Meeting Abstract
Critical Care Medicine
N. G. Casanova, N. Pouladi, Y. Lussier, J. Navarrete, J. Berghout, M. L. Gonzalez-Garay, K. S. Knox, J. G. N. Garcia
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)