Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors

An integration-defective lentivirus-based resource for site-specific targeting of an edited safe-harbour locus in the human genome

(2014) R Torres et al.   GENE THERAPY

Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system

(2014) R. Torres et al.   Nature Communications

Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

(2012) S. Matsuura et al.   BLOOD

Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1–DTX2 chimera

(2012) Kazuhiro Maki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs

(2012) A Maiques-Diaz et al.   LEUKEMIA

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

(2010) S. Schnittger et al.   BLOOD

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

RUNX1translocations and fusion genes in malignant hemopathies

(2010) Etienne De Braekeleer et al.   Future Oncology

DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia

(2010) Sara Alvarez et al.   PLoS One

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations

(2009) J.-L. Tang et al.   BLOOD

Cell cycle and developmental control of hematopoiesis by Runx1

(2009) Alan D. Friedman   JOURNAL OF CELLULAR PHYSIOLOGY

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

(2009) X Liu et al.   LEUKEMIA

AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain

(2008) Hui Wei et al.   FEBS LETTERS

Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9

(2008) Takatoshi Aoki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Gatekeeper function of the RUNX1 transcription factor in acute leukemia

(2007) Birte Niebuhr et al.   BLOOD CELLS MOLECULES AND DISEASES