Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Yan Meng, Zhengbo Tao, Siming Zhou, Wacili Da, Lin Tao
Summary: This study conducted a quantitative and qualitative analysis of melatonin research over the past 20 years using bibliometric methods, predicting future research trends. Findings showed that the United States had the highest number of publications in melatonin research, and future research hot spots are likely to focus on the structure and function of melatonin, clinical applications, and target-based drug design.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Wenbo Jiang, Huanyu Wu, Rui Guo, Xiaoqing Xu, Yue Wang, XiTao Jiang, Yu Wang, Xuemin Yan, Wenbo Gu, Xin Liu, Fengyu Cao, Ying Li, Tianshu Han, Changhao Sun
Summary: This study found that Dibromoacetic acid (DBA) can induce neurotoxicity in the pineal gland and disrupt melatonin rhythm by inhibiting the p-CREB1-AANAT signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Endocrinology & Metabolism
Aurea S. Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F. Rath
Summary: This study aims to investigate the role of clock genes on pineal gland endocrine function, particularly on the enzyme Aanat involved in melatonin synthesis. It was found that rhythmic clock gene expression in the pineal gland largely depends on the suprachiasmatic nucleus (SCN) and pineal cells house a slave oscillator controlled by adrenergic signaling. Histological analysis revealed that clock genes are expressed in pinealocytes and colocalize with Aanat transcripts, suggesting their involvement in cellular melatonin production. Knockdown of the clock gene Clock led to an overexpression of Aanat in pinealocytes, indicating that SCN-dependent rhythmic expression of Clock gene regulates the daily profile of Aanat expression.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rehab T. Oshiba, Ehab Touson, Yasser M. Elsherbini, Mohamed E. Abdraboh
Summary: This study demonstrates the significant impact of melatonin in counteracting tumor growth through scavenging free radicals, regulating lipid peroxidation, and affecting cell cycle and apoptosis. The signaling pathways of melatonin in adenocarcinoma have been highlighted, emphasizing the novel role of M./P53/miR215/CD44 and M./miR96//foxO1 cascades in diminishing cancer cell growth, survival, and metastasis.
Article
Physiology
Natalia Ziolkowska, Bogdan Lewczuk
Summary: This study demonstrated the significant impact of norepinephrine and light exposure on melatonin secretion in goose pineal explants. It was found that norepinephrine played a key role in regulating pineal secretory activity, especially in maintaining the rhythmicity of melatonin. Additionally, the levels of VMA and HMV in the pineal glands provided precise information about the activity of sympathetic nerve fibers in geese.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo Hyun Lee, Bertil Hille, Duk-Su Koh
Summary: The pineal gland secretes melatonin at night, regulated by sympathetic nerve terminals. The secretion of 5-HT is primarily through a specific transporter, and activation of receptors on pinealocytes affects melatonin release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Wei Ge, Zi-Hui Yan, Lu Wang, Shao-Jing Tan, Jing Liu, Russel J. Reiter, Shi-Ming Luo, Qing-Yuan Sun, Wei Shen
Summary: This study revealed the gene regulatory network of different cell populations in the rat pineal gland through single-cell RNA sequencing, characterized the activation of autophagy flux during day/night, and suggested a potential role of autophagy in regulating melatonin synthesis. Additionally, the study provided insights into cell-cell communication in the rat pineal gland.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Kuno M. -J. Mattern, Aurea S. Blancas-Velazquez, Mikaella T. Ngo, Signe Bille, Henrik Hertz, Tenna Bering, Martin F. Rath
Summary: ISL2 gene exhibits a circadian rhythm in the pineal gland, regulated by the suprachiasmatic nucleus. ISL2 negatively regulates melatonin synthesis during the daytime and is repressed by adrenergic signaling and other transcription factors during the nighttime.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Kuno M. -J. Mattern, Aurea S. Blancas-Velazquez, Mikaella T. Ngo, Signe Bille, Henrik Hertz, Tenna Bering, Martin F. Rath
Summary: ISL2 is a homeodomain transcription factor expressed in the rat pineal gland, and its expression is regulated by adrenergic signaling and the circadian rhythm. ISL2 negatively regulates daytime expression of Aanat, enhancing the circadian rhythm in melatonin synthesis.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Henrik Hertz, Aurea Susana Blancas-Velazquez, Martin Fredensborg Rath
Summary: Homeobox genes are expressed postnatally in the pineal gland and retina, playing a role in melatonin synthesis and phototransduction. Rat pinealocyte culture is used as an in vitro model for studying retinal phototransduction. Individual knockdown of certain homeobox genes in pinealocytes led to downregulation of phototransduction genes, suggesting that homeobox gene-encoded transcription factors control postnatal expression of phototransduction genes in the retinal photoreceptor.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Cell Biology
Anna Ashton, Jason Clark, Julia Fedo, Angelo Sementilli, Yara D. D. Fragoso, Peter McCaffery
Summary: The pineal gland regulates the circadian timing system through melatonin production. The study investigates the interaction between the pineal gland and retinoic acid (RA) signaling system. It is found that there is conservation of the RA signaling system in mammalian species, but RA does not have a short-term effect on clock gene expression. Unexpectedly, melatonin was found to suppress the induction of gene transcription by RA.
Article
Multidisciplinary Sciences
Tina Oldham, Frode Oppedal, Per Gunnar Fjelldal, Tom Johnny Hansen
Summary: This experiment examines how light intensity variations affect perceived photoperiod in Atlantic salmon and reveals the importance of adaptive photoperiod interpretation in the development and reproduction of the species.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Ouissam El Bakouri, Dariusz W. Szczepanik, Kjell Jorner, Rabia Ayub, Patrick Bultinck, Miquel Sola, Henrik Ottosson
Summary: Several fully pi-conjugated macrocycles with puckered or cage-type structures were found to exhibit aromatic character. However, they should be described as 2D-aromatic-in-3D structures rather than truly 3D-aromatic compounds. Their aromaticity comes from the fulfillment of specific rules and is related to naphthalene.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Medicine, General & Internal
Daniel Gashaneh Belay, Misganaw Gebrie Worku
Summary: This study aimed to assess the pooled prevalence of pineal gland calcification. The pooled prevalence of pineal gland calcification was found to be 61.65%, with age, male sex, and white ethnicity being the major socio-demographic characteristics that increase the prevalence of this condition.
SYSTEMATIC REVIEWS
(2023)
Article
Ecology
M. Ruiz-Rodriguez, M. Scheifler, S. Sanchez-Brosseau, E. Magnanou, N. West, M. Suzuki, S. Duperron, Y. Desdevises
Article
Physiology
Laura Gabriela Nisembaum, Patrick Martin, Michael Fuentes, Laurence Besseau, Elodie Magnanou, Stephen D. McCormick, Jack Falcon
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2020)
Review
Evolutionary Biology
Natacha Roux, Pauline Salis, Shu-Hua Lee, Laurence Besseau, Vincent Laudet
Article
Fisheries
A. Gaon, O. Nixon, A. Tandler, J. Falcon, L. Besseau, M. Escande, S. El Sadin, G. Allon, W. Koven
Summary: The study tested the effect of different levels of dietary taurine on vision, prey hunting success, and growth in developing larval gilthead sea bream. Results showed that taurine significantly improved vision and promoted growth in the larvae.
Article
Evolutionary Biology
Natacha Roux, Valentin Logeux, Nancy Trouillard, Remi Pillot, Kevin Magre, Pauline Salis, David Lecchini, Laurence Besseau, Vincent Laudet, Pascal Romans
Summary: As interest grows in Eco-Evo-Devo, wild species are being used as experimental models, yet a suitable model for marine fish species, particularly coral reef fishes that can be reared at laboratory scales, is still lacking. Extensive knowledge of anemonefish life cycle and biology make them relevant marine fish models for developmental biology, ecology, and evolutionary sciences.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2021)
Article
Plant Sciences
Sylvie Oddou-Muratorio, Cathleen Petit-Cailleux, Valentin Journe, Matthieu Lingrand, Jean-Andre Magdalou, Christophe Hurson, Joseph Garrigue, Hendrik Davi, Elodie Magnanou
Summary: The study in a drought-prone population of European beech found that individual fecundity and growth were influenced by crown defoliation and competition, with large trees contributing to reproduction through seed production and pollination despite reduced growth. This non-coordinated decline of growth and fecundity at individual level in response to stress may compromise the evolution of stress-resistance traits at population level, and increase forest tree vulnerability.
Review
Endocrinology & Metabolism
Laura Gabriela Nisembaum, Patrick Martin, Frederic Lecomte, Jack Falcon
Summary: The life cycle of fish species such as sea bass and Atlantic salmon involve significant salinity changes. The process of smoltification enables juveniles to migrate downstream and adapt to seawater, with factors like photoperiod and temperature influencing its timing. Studies on neuroendocrine mechanisms suggest a possible role of melatonin in controlling smoltification.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Physiology
Jack Falcon, Maria Jesus Herrero, Laura Gabriela Nisembaum, Esther Isorna, Elodie Peyric, Marilyn Beauchaud, Joel Attia, Denis Coves, Michael Fuentes, Maria Jesus Delgado, Laurence Besseau
Summary: The hormone melatonin plays a crucial role in regulating pituitary hormone production in European sea bass, influenced by factors like photoperiod, temperature, and salinity. Seasonal variations in mRNA abundance of pituitary hormones and melatonin receptors were observed in different fish groups raised in sea water and brackish water. In vitro experiments showed that melatonin's effects on pituitary hormones varied based on concentration, month investigated, and fish's prior adaptation to different salinities, highlighting the diverse responses of the pituitary gland in fish facing changing environmental conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Laura Gabriela Nisembaum, Guillaume Loentgen, Thibaut L'Honore, Patrick Martin, Charles-Hubert Paulin, Michael Fuentes, Karine Escoubeyrou, Maria Jesus Delgado, Laurence Besseau, Jack Falcon
Summary: Fish rely on external temperature and photoperiod to regulate their metabolism, physiology, and behavior. Recent studies have found that TRPV1 and TRPV4 channels play a role in regulating melatonin production in Atlantic salmon, possibly in response to temperature changes.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Environmental Sciences
Victoria Louis, Laurence Besseau, Franck Lartaud
Summary: Biomineralisation is the process by which organisms induce the precipitation of minerals to form hard tissues, and shells of bivalves are used as biological archives of paleo-environmental and paleo-climatic conditions. However, the environmental drivers of shell increment formation are still poorly understood.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cell Biology
Leo Michel, Karina Palma, Mauricio Cerda, Ronan Lagadec, Helene Mayeur, Michael Fuentes, Laurence Besseau, Patrick Martin, Elodie Magnanou, Patrick Blader, Miguel L. Concha, Sylvie Mazan
Summary: Habenula asymmetries are widespread and conserved in vertebrates, and zebrafish is a reference model organism for studying this process. However, the general characteristics of this trait in other teleosts, including the Atlantic salmon, remain uncertain. This study characterizes the organization of habenulae in the Atlantic salmon and reveals the presence of asymmetries, similar to zebrafish. A unique left-restricted pax6 positive nucleus is observed in the Atlantic salmon but not in zebrafish, suggesting an ancient origin and high evolvability of this trait. These findings raise questions about the variability and ecological significance of asymmetries across teleosts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Laurence Besseau, Laura Gabriela Nisembaum
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Natacha Roux, Saori Miura, Melanie Dussenne, Yuki Tara, Shu-hua Lee, Simon de Bernard, Mathieu Reynaud, Pauline Salis, Agneesh Barua, Abdelhay Boulahtouf, Patrick Balaguer, Karine Gauthier, David Lecchini, Yann Gibert, Laurence Besseau, Vincent Laudet
Summary: Most marine organisms go through a two-phase life cycle, where pelagic larvae transform into juvenile forms. The role of thyroid hormones (THs) in triggering this transition is well understood in vertebrates. However, the integration of morphological and physiological changes with the ecological transition is not well explored. In this study, researchers analyzed the metamorphosis of the false clownfish and showed how THs coordinate changes in color vision and energy production during this transformation. They also identified a strong link between metabolic changes and metamorphosis progression through the manipulation of liver X regulator (LXR) activity. Furthermore, they found these regulations to be present in the wild, highlighting the importance of hormone coordination in meeting energy needs during the life cycle.
Article
Environmental Sciences
Jose Antonio Paullada-Salmeron, Guillaume Henri Loentgen, Michael Fuentes, Laurence Besseau, Takayoshi Ubuka, Evaristo Luis Mananos, Jose Antonio Munoz-Cueto
Summary: Neurosteroids play a role in regulating various behavioral and physiological processes in the vertebrate brain, but the central mechanisms of neurosteroid synthesis are not well understood.
FRONTIERS IN MARINE SCIENCE
(2023)