Article
Cell Biology
K. Terada, A. Yoshizawa, S. Sumiyoshi, M. Rokutan-Kurata, N. Nakajima, M. Hamaji, M. Sonobe, T. Menju, H. Date, H. Haga
Summary: This study investigated the clinicopathological characteristics of CK5-positive pulmonary adenocarcinoma (ADC) and found that CK5-positive ADCs exhibit aggressive clinical behavior with high-grade morphology and mucinous differentiation.
Article
Immunology
Paul Griebel, Florian Tran, Janina Luehring, Stefan Schreiber
Summary: Autoimmune pancreatitis responds well to corticosteroids in most cases. If relapse occurs, additional immunosuppression or low-dose maintenance steroids may be necessary. This case report suggests that vedolizumab may be an effective alternative therapy for refractory autoimmune pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Jasinski, Lukasz Zdrojkowski, Graca Ferreira-Dias, Ewa Kautz, Edyta Juszczuk-Kubiak, Malgorzata Domino
Summary: Endometrosis, a common disease that affects mares' fertility, is associated with alterations in epithelial and stromal cells, as well as degeneration and fibrosis of the endometrium. The study reveals a potential involvement of the NF-kappa B pathway in the pathogenesis of endometrosis, showing differential transcription of profibrotic genes between different phases of the estrous cycle. Additionally, the transcription of estrogen and progesterone receptors is found to be decreased with the severity of fibrosis and degeneration of the endometrium in horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Soares, Assuncao N. Correia, Mariana R. Batista, Jorge Correia, Fernando Ferreira
Summary: Benign feline mammary lesions are common in domestic cats, and the expression of estrogen receptors plays an important role in their development.
Article
Chemistry, Medicinal
John R. Schultz, Stephen K. Costa, Gorakhnath R. Jachak, Pooja Hegde, Matthew Zimmerman, Yan Pan, Michaele Josten, Chinedu Ejeh, Travis Hammerstad, Hans Georg Sahl, Pedro M. Pereira, Mariana G. Pinho, Veronique Dartois, Ambrose Cheung, Courtney C. Aldrich
Summary: Nosocomial infections caused by resistant Gram-positive organisms are increasing, and new drugs are urgently needed. This study describes the identification of a 5-amino-4-quinolone with potent Gram-positive activity and preliminary understanding of its mechanism of action and resistance. The compound shows promising antibacterial properties and warrants further investigation for the treatment of Gram-positive infections.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner
Summary: Kleiner and his colleagues profile RNA 5-methylcytidine dioxygenase enzymes using an activity-based metabolic probing strategy, identifying ALKBH1 as the major writer of 5-formylcytidine. Their study characterizes modification sites across mRNA and tRNA, revealing the regulatory role of epitranscriptomic RNA modifications. They propose a chemoproteomic strategy to study RNA 5-methylcytidine dioxygenases in their native context and map oxidative m5C modifications. The research uncovers novel epitranscriptomic pathways for regulating RNA function.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Article
Cell Biology
Reema S. Wahdan-Alaswad, Susan M. Edgerton, Hyun Min Kim, Aik Choon Tan, Bryan R. Haugen, Bolin Liu, Ann D. Thor
Summary: Expression and signaling of estrogen receptor (ERα) play a major role in breast cancer development. Interactions with thyroid hormones and their receptors can lead to endocrine therapy resistance. A study found that thyroid hormone replacement therapy is significantly associated with higher rates of relapse and mortality in breast cancer patients, especially those who are steroid receptor positive and node-negative. In in vivo and in vitro experiments, researchers discovered that thyroid hormone in combination with estrogen and tamoxifen can enhance cell proliferation and resistance to tamoxifen in breast cancer cells.
Article
Infectious Diseases
Teng Xu, Fenfen Zhou, Li Wang, Shi Wu, Haihui Huang
Summary: This study investigates the genomic and transcriptional changes associated with metronidazole resistance in Clostridioides difficile strains. The findings reveal an association between genomic variation and metronidazole resistance, and suggest that metronidazole resistance in C. difficile is influenced by factors such as metronidazole metabolism, cell wall thickness, and efflux pumps. These findings contribute to a better understanding of metronidazole resistance in C. difficile.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Oncology
Reema S. Wahdan-Alaswad, Susan M. Edgerton, Hiba Salem, Hyun Min Kim, Aik Choon Tan, Jessica Finlay-Schultz, Elizabeth A. Wellberg, Carol A. Sartorius, Britta M. Jacobsen, Bryan R. Haugen, Bolin Liu, Ann D. Thor
Summary: The study revealed clinically significant adverse interactions between THRT, estrogenic, and oncogenic signaling in patients with steroid receptor-positive, lymph node-negative breast cancer.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Xiaoli Zhu, Anjin Hong, Xihuan Sun, Weijie Wang, Guanghui He, Huan Luo, Zhenhua Wu, Qingyan Xu, Zhiyu Hu, Xiaobing Wu, Donghong Huang, Li Li, Xilin Zhao, Xianming Deng
Summary: Nigericin demonstrates potent bactericidal activity against multidrug-resistant Gram-positive bacteria, persisters, and biofilms, with low frequencies of resistance development. It shows promising potential for treating chronic or recurrent infections caused by Gram-positive bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Ke Liu, Jun Huang, Jiao Liu, Daniel J. Klionsky, Rui Kang, Daolin Tang
Summary: Carboplatin-resistant RB cells exhibit higher autophagy activity compared to parent cells, leading to multi-drug resistance. This study introduces a new strategy of inducing autophagy-dependent ferroptosis to eliminate drug-resistant RB cells. The effectiveness and safety of a cell-permeable derivative of itaconate in inducing ferritinophagy-dependent ferroptosis were evaluated.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Qingxiao Song, Xiaoning Wang, Xiwei Wu, Tae Hyuk Kang, Hanjun Qin, Dongchang Zhao, Robert R. Jenq, Marcel R. M. van den Brink, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Summary: The pathogenesis of SR-Gut-aGVHD involves the expansion of Th/Tc22 cells causing dysbiosis and reduction of Th/Tc1 cells leading to depletion of CX3CR1(hi) mononuclear phagocytes. Potential therapeutic strategies for SR-Gut-aGVHD include IL-22 antagonists and IFN-γ agonists.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Neil Portman, Julia Chen, Elgene Lim
Summary: This review explores the role of the p53/MDM2 axis in the treatment of ER+ breast cancer and the potential of targeting p53/MDM2 by inhibiting MDM2 in the setting of CDK4/6i resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Yanfeng Shi, Yijun Li, Chao Huang, Yanfeng Xu, Yuanhong Xu
Summary: In this study, electropositive copper selenide (CuSe) nanosheets were prepared using an electrochemical method and showed high efficacy in killing resistant bacteria models with extremely low effective dose and low cytotoxicity. Furthermore, these nanosheets exhibited excellent performance in promoting wound healing in rats infected with resistant bacteria.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Oncology
Shauna R. Campbell, Elizabeth B. Jeans, Ashley Albert, Ankit Agarwal, Karen Tye, Chelain R. Goodman
Summary: Radiation oncology residents spend substantial time preparing for the IC examinations in 2019, impacting training and health outcomes. There is variation in the quality of internal program physics and radiobiology courses, with support for the development of a consensus radiation oncology curriculum and preference for consolidating the three qualifying examinations into a single written IC examination.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Oncology
James E. Bates, Akash Parekh, Chelain R. Goodman, Mudit Chowdhary, Matthew M. Culbert, Trevor J. Royce, Robert J. Amdur
Summary: This study analyzed the employment outcomes of radiation oncology residents in 2019 and found that most graduates chose to work in counties within major metropolitan areas, with only a small proportion working in nonmetropolitan areas. Graduates of smaller programs and those in smaller metropolitan areas were more likely to work in similar settings but might not do so locally.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
John A. Marsiglio, David M. Rosenberg, Michael K. Rooney, Chelain R. Goodman, Erin F. Gillespie, Ariel E. Hirsch, Emma B. Holliday, Randall J. Kimple, Charles R. Thomas Jr, Daniel W. Golden
Summary: The study investigated the state of mentorship in radiation oncology and found that mentorship initiatives were successful in promoting career development and increasing professional satisfaction. The most commonly described form of mentorship was the dyad, and the most commonly mentored participants were residents and medical students. Future scholarship has rich opportunities to further develop, evaluate, and disseminate radiation oncology mentorship initiatives.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Multidisciplinary Sciences
Patrick D. Radler, Barbara L. Wehde, Aleata A. Triplett, Hridaya Shrestha, Jonathan H. Shepherd, Adam D. Pfefferle, Hallgeir Rui, Robert D. Cardiff, Charles M. Perou, Kay-Uwe Wagner
Summary: Claudin-low breast cancer is an aggressive subtype mainly composed of triple-negative mammary tumor cells with stem cell-like and mesenchymal features. The consistent activation of oncogenic RAS signaling and regulators of EMT play crucial roles in maintaining the cellular plasticity and characteristics of claudin-low mammary cancer cells.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Brenton A. Maisel, Misung Yi, Amy R. Peck, Yunguang Sun, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Marja T. Nevalainen, Takemi Tanaka, Nicole Simone, Li Lily Wang, Hallgeir Rui, Inna Chervoneva
Summary: The density and spatial relationship of CD163(+) TAMs in tumor tissue are associated with unfavorable prognosis in breast cancer.
Article
Oncology
Laura L. Dover, Courtney Hentz, Jenna M. Kahn, Anna Lee, Adrianna Masters, Kaleigh Doke, Chelain R. Goodman
Summary: The current structure and schedule of the American Board of Radiology (ABR) radiation oncology initial certification (RO-IC) examinations have significant implications for family planning and early professional development among female radiation oncologists. The transition to virtual examination platforms presents an important opportunity to improve equitable board certification practices.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Substance Abuse
Marie-Cecile Bralet, Serge A. Mitelman, Chelain R. Goodman, Samantha Lincoln, Erin A. Hazlett, Monte S. Buchsbaum
Summary: This study found that patients with alcohol use disorder (AUD) had lower metabolic rates in the frontal, temporal, and parietal lobes, but higher rates in the medial orbitofrontal and anterior cingulate cortex. The severity of alcohol-related consequences was associated with decreased metabolism in specific brain regions.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Oncology
Kelsey L. Corrigan, Xiudong Lei, Neelofur Ahmad, Isidora Arzu, Elizabeth Bloom, Stephen G. Chun, Chelain Goodman, Karen E. Hoffman, Melissa Joyner, Lauren Mayo, Melissa Mitchell, Kevin T. Nead, George H. Perkins, Valerie Reed, Jay P. Reddy, Pamela Schlembach, Simona F. Shaitelman, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Lee Wiederhold, Wendy A. Woodward, Benjamin D. Smith
Summary: This study analyzed the adoption of ultra-hypofractionated whole-breast irradiation for ductal carcinoma in situ and early-stage invasive breast cancer after the publication of a high-quality clinical trial supporting its use. The results showed a significant increase in the use of ultra-hypofractionated whole-breast irradiation after the trial publication, particularly in patients with lower risk disease.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Charles Clevenger, Hallgeir Rui
Summary: The pathogenesis of breast cancer is influenced by various hormones and growth factors, including prolactin (PRL). Recent studies have shed light on the roles of PRL receptors and PRL in tumorigenesis and tumor progression. One study revealed opposing actions of PRL in the breast, mediated by different isoforms of PRL receptors. Another study introduced an immunodeficient, prolactin-humanized mouse model that facilitates the growth of PRL receptor-expressing patient-derived breast cancer xenografts. These findings provide new insights and potential therapeutic targets for breast cancer treatment.
Editorial Material
Oncology
Chelain R. Goodman, Jonathan B. Strauss
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Mark D. Hurwitz, Anupama Chundury, Chelain R. Goodman, Joshua Jones, Simon S. Lo, Hina Saeed, William Small Jr, Naomi R. Schechter
Summary: Consent is a communication process between patients and healthcare providers to protect patients' autonomy in decision-making. It reduces conflicts of interest and builds trust. This document serves as an educational tool to facilitate informed consent.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Article
Oncology
Anusha Gandhi, Tianlin Xu, Sarah M. DeSnyder, Grace L. Smith, Ruitao Lin, Carlos H. Barcenas, Michael C. Stauder, Karen E. Hoffman, Eric A. Strom, Susan Ferguson, Benjamin D. Smith, Wendy A. Woodward, George H. Perkins, Melissa P. Mitchell, Desmond Garner, Chelain R. Goodman, Melissa Aldrich, Marigold Travis, Susan Lilly, Isabelle Bedrosian, Simona F. Shaitelman
Summary: This study examined the impact of breast cancer-related lymphedema (BCRL) on health-related quality of life (HRQOL), productivity, and compliance with therapeutic interventions. The results showed that the incidence of BCRL increased over time, with a high proportion of patients reporting fear of BCRL. BCRL was associated with worse HRQOL and productivity, and long-term compliance with recommended interventions should be promoted.
Meeting Abstract
Oncology
Praveen-Kumar Raj-Kumar, Tao Liu, Lori A. Sturtz, Albert J. Kovatich, Marina A. Gritsenko, Vladislav A. Petyuk, Brenda Deyarmin, Jianfang Liu, Anupama Praveen-Kumar, Jason E. McDermott, Anil K. Shukla, Ronald J. Moore, Matthew E. Monroe, Bobbie-Jo M. Webb-Robertson, Jeffrey A. Hooke, Leigh Fantacone-Campbell, Leonid Kvecher, Jennifer Kane, Jennifer Melley, Stella Somiari, Stephen C. Benz, Justin Golovato, Shahrooz Rabizadeh, Patrick Soon-Shiong, Richard D. Smith, Richard J. Mural, Karin D. Rodland, Craig D. Shriver, Zhaoyu Li, Hai Hu
Meeting Abstract
Oncology
Valerie Bussberg, Vladimir Tolstikov, Guisong Wang, Punit Shah, Rick Searfoss, Leigh Fantacone-Campbell, Jeffrey A. Hooke, Brenda Deyarmin, Rebecca N. Zingmark, Stella Somiari, Jianfang Liu, Leonid Kvecher, Bradley Mostoller, Lori Sturtz, Praveen-Kumar Raj-Kumar, Elder Granger, Linda Vahdat, Mary L. Cutler, Chas Bountra, Rangaprasad Sarangarajan, Hai Hu, Albert J. Kovatich, Michael A. Kiebish, Niven R. Narain, Craig D. Shriver